Publications 2016

Publications 2015

Spatially resolved transcriptomics and beyond
2015 in Nature Reviews Genetics

Nicola Crosetto, Magda Bienko, Alexander van Oudenaarden

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish
2015 in Journal of Endocrinology

Vanesa Jiménez-Amilburu, Susanne Jong-Raadsen, Jeroen Bakkers, Herman P Spaink, Rubén Marín-Juez

Lack of Major Genome Instability in Tumors of p53 Null Rats
2015 in PLoS One

Roel Hermsen, Pim Toonen, Ewart Kuijk, Sameh A Youssef, Raoul Kuiper, Sebastiaan van Heesch, Alain de Bruin, Edwin Cuppen, Marieke Simonis

Genetic etiology of renal agenesis
2015 in PLoS One

Nyssa Becker Samanas, Tessa W Commers, Kirsten L Dennison, Quincy Eckert Harenda, Scott G Kurz, Cynthia M Lachel, Kristen Leland Wavrin, Michael Bowler, Isaac J Nijman, Victor Guryev, Edwin Cuppen, Norbert Hubner, Ruth Sullivan, Chad M Vezina, James D Shull

Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells
2015 in Nature Communications

Inge The, Suzan Ruijtenberg, Benjamin P Bouchet, Alba Cristobal, Martine B W Prinsen, Tim van Mourik, John Koreth, Huihong Xu, Albert J R Heck, Anna Akhmanova, Edwin Cuppen, Mike Boxem, Javier Muñoz, Sander van den Heuvel

Simultaneous detection of clinically relevant mutations and amplifications for routine cancer pathology
2015

Marlous Hoogstraat, John W J Hinrichs, Nicolle J M Besselink, Joyce H Radersma-van Loon, Carmen M A de Voijs, Ton Peeters, Isaac J Nijman, Roel A de Weger, Emile E Voest, Stefan M Willems, Edwin Cuppen, Marco J Koudijs

Efficient cryopreservation of human pluripotent stem cells by surface-based vitrification
2015

Julia C Neubauer, Axel F Beier, Niels Geijsen, Heiko Zimmermann

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA
2015 in Nature Communications

Nicolas Léveillé, Carlos A Melo, Koos Rooijers, Angel Díaz-Lagares, Sonia A Melo, Gozde Korkmaz, Rui Lopes, Farhad Akbari Moqadam, Ana R Maia, Patrick J Wijchers, Geert Geeven, Monique L den Boer, Raghu Kalluri, Wouter de Laat, Manel Esteller, Reuven Agami

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations
2015

Johan H van Es, Hans Clevers

Targeting development of incretin-producing cells increases insulin secretion
2015 in Journal of Clinical Investigation

Natalia Petersen, Frank Reimann, Johan H van Es, Bernard M van den Berg, Chantal Kroone, Ramona Pais, Erik Jansen, Hans Clevers, Fiona M Gribble, Eelco J P de Koning

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
2015 in Gastroenterology

Sina Bartfeld, Tülay Bayram, Marc van de Wetering, Meritxell Huch, Harry Begthel, Pekka Kujala, Robert Vries, Peter J Peters, Hans Clevers

Discovery of molecular markers to discriminate corneal endothelial cells in the human body
2015 in PLoS One

Masahito Yoshihara, Hiroko Ohmiya, Susumu Hara, Satoshi Kawasaki, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji, Motokazu Tsujikawa, Kohji Nishida, FANTOM consortium, J.C. Clevers, M.L. van de Wetering

Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression
2015 in Nature Communications

Jeroen Sebastiaan van Zon, Simone Kienle, Guizela Huelsz-Prince, Michalis Barkoulas, Alexander van Oudenaarden

Translational regulation shapes the molecular landscape of complex disease phenotypes
2015 in Nature Communications

Sebastian Schafer, Eleonora Adami, Matthias Heinig, Katharina E Costa Rodrigues, Franziska Kreuchwig, Jan Silhavy, Sebastiaan van Heesch, Deimante Simaite, Nikolaus Rajewsky, Edwin Cuppen, Michal Pravenec, Martin Vingron, Stuart A Cook, Norbert Hubner

Genomic landscape of rat strain and substrain variation
2015 in BMC Genomics

Roel Hermsen, Joep de Ligt, Wim Spee, Francis Blokzijl, Sebastian Schäfer, Eleonora Adami, Sander Boymans, Stephen Flink, Ruben van Boxtel, Robin H van der Weide, Tim Aitman, Norbert Hübner, Marieke Simonis, Boris Tabakoff, Victor Guryev, Edwin Cuppen

Structure-guided design of selective Epac1 and Epac2 agonists
2015 in PLoS Biology

Frank Schwede, Daniela Bertinetti, Carianne N Langerijs, Michael A Hadders, Hans Wienk, Johanne H Ellenbroek, Eelco J P de Koning, Johannes L Bos, Friedrich W Herberg, Hans-Gottfried Genieser, Richard A J Janssen, Holger Rehmann

In Situ Hybridization to Identify Gut Stem Cells
2015 in Current Protocols in Stem Cell Biology

Alex Gregorieff, Hans Clevers

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
2015 in PLoS One

Hanneke Hoelen, Arnaud Zaldumbide, Wouter F van Leeuwen, Ellen C W Torfs, Marten A Engelse, Chopie Hassan, Robert Jan Lebbink, Eelco J de Koning, Maaike E Resssing, Arnoud H de Ru, Peter A van Veelen, Rob C Hoeben, Bart O Roep, Emmanuel J H J Wiertz

Getting the genome in shape
2015 in Genome Biology

Britta Am Bouwman, Wouter de Laat

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq
2015 in Genome Biology

Hendrik Marks, Hindrik H D Kerstens, Tahsin Stefan Barakat, Erik Splinter, René A M Dirks, Guido van Mierlo, Onkar Joshi, Shuang-Yin Wang, Tomas Babak, Cornelis A Albers, Tüzer Kalkan, Austin Smith, Alice Jouneau, Wouter de Laat, Joost Gribnau, Hendrik G Stunnenberg