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2001   2002   2003   2004   2005

Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B., Hammerschmidt, M. (2005) Destabilization of ?Np63a by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo. Cell Cycle 4: 790-800.

Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., van de Born, M., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S., Clevers, H. (2005) EphB receptor activity suppresses colorectal cancer progression. Nature 435: 1126-1130.

Berezikov, E., Guryev, V., Cuppen, E. (2005) CONREAL web server: identification and visualization of conserved transcription factor binding sites. Nucleic Acids Res. 33: W447-W450.
Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R.H.A., Cuppen, E. (2005) Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120: 21-24.

Berezikov, E., Plasterk, R.H.A. (2005) Camels and zebrafish, viruses and cancer: a microRNA update. Hum. Mol. Genet. 14: R183-R190.

Berghmans, S., Murphey, R.D., Wienholds, E., Neuberg, D., Kutok, J.L., Fletcher, C.D.M., Morris, J.P., Liu, T.X., Schulte-Merker, S., Kanki, J.P., Plasterk, R., Zon, L.I., Look, A.T. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc. Natl. Acad. Sci. 102: 407-412.

Blonden, L., van ‘t Padje, S., Severijnen, L.-A., Destrée, O., Oostra, B.A., Willemsen, R. (2005) Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis. Int. J. Dev. Biol. 49: 437-442.

Bodrikov, V., Leshchyns’ka, I., Sytnyk, V., Overvoorde, J., den Hertog, J., Schachner, M. (2005) RPTPa is essential for NCAM-mediated p59fyn activation and neurite elongation. J. Cell Biol. 168: 127-139.

Bubikat, A., de Windt, L.J., Zetsche, B., Fabritz, L., Sickler, H., Eckardt, D., Gödecke, A., Baba, H.A., Kuhn, M. (2005) Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice. J. Biol. Chem. 280: 21594-21599.

Chuva de Sousa Lopes, S.M., van den Driesche, S., Carvalho, R.L.C., Larsson, J., Eggen, B., Surani, M.A., Mummery, C.L. (2005) Altered primordial germ cell migration in the absence of transforming growth factor ? signaling via ALK5. Dev. Biol. 284: 194-203.

Clevers, H. (2005) Stem cells, asymmetric division and cancer. Nat. Genet. 37: 1027-1028.

Coudreuse, D. (2005) Wnts and worms: from nematodes to vertebrates. Thesis, Univ. Utrecht, pp. 1-144.

Creyghton, M.P., Roël, G., Eichhorn, P.J.A., Hijmans, E.M., Maurer, I., Destrée, O., Bernards, R. (2005) PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 19: 376-386.

Cuppen, E. (2005) Haplotype-based genetics in mice and rats. Trends Genet. 21: 318-322.

de Boer, T.P., Kok, B., Neuteboom, K.I.E., Spieker, N., de Graaf, J., Destrée, O.H.J., Rook, M.B., van Veen, T.A.B., Jongsma, H.J., Vos, M.A., de Bakker, J.M.T., van der Heyden, M.A.G. (2005) Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis. Dev. Dyn. 233: 864-871.

de Guzman, B.B., Hisatsune, J., Nakayama, M., Yahiro, K., Wada, A., Yamasaki, E., Nishi, Y., Yamazaki, S., Azuma, T., Ito, Y., Ohtani, M., van der Wijk, T., den Hertog, J., Moss, J., Hirayama, T. (2005) Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPa and RPTP?, by Helicobacter pylori m2VacA. Cell. Microbiol. 7: 1285-1293.

den Hertog, J. (2005) Chemical genetics: drug screens in zebrafish. Biosci. Rep. 25: 289-297.

den Hertog, J., Groen, A., van der Wijk, T. (2005) Redox regulation of protein-tyrosine phosphatases. Arch. Biochem.Biophys. 434: 11-15.

Denning, C., Passier, R., Mummery, C. (2005) Differentiation of human embryonic stem cells to cardiomyocytes. In: Stem cells: from bench to bedside. Eds. Bongso, A., Lee, E.H., Singapore, World Scientific Press, pp. 301-324.

Deschamps, J., van Nes, J. (2005) Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development 132: 2931-2942.

Donners, M.M.P.C., Bot, I., de Windt, L.J., van Berkel, Th.J.C., Daemen, M.J.A.P., Biessen, E.A.L., Heeneman, S. (2005) Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice. Am. J. Transplant. 5: 1204-1215.

Essers, M.A.G., de Vries-Smits, L.M.M., Barker, N., Polderman, P.E., Burgering, B.M.T., Korswagen, H.C. (2005) Functional interaction between ?-catenin and FOXO in oxidative stress signaling. Science 308: 1181-1184.

Forcet, C., Etienne-Manneville, S., Gaude, H., Fournier, L., Debilly, S., Salmi, M., Baas, A., Olschwang, S., Clevers, H., Billaud, M. (2005) Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum. Mol. Genet. 14: 1283-1292.

Glass II, D.A., Bialek, P., Ahn, J.D., Starbuck, M., Patel, M.S., Clevers, H., Taketo, M.M., Long, F., McMahon, A.P., Lang, R.A., Karsenty, G. (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8: 751-764.

Gregorieff, A., Clevers, H. (2005) Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev. 19: 877-890.

Gregorieff, A., Pinto, D., Begthel, H., Destrée, O., Kielman, M., Clevers, H. (2005) Expression pattern of wnt signaling components in the adult intestine. Gastroenterology 129: 626-638.

Groen, A., Lemeer, S., van der Wijk, Th., Overvoorde, J., Heck, A.J.R., Ostman, A., Barford, D., Slijper, M., den Hertog, J. (2005) Differential oxidation of protein-tyrosine phosphatases. J. Biol. Chem. 280: 10298-10304.

Guryev, V., Berezikov, E., Cuppen, E. (2005) CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences. BMC Genomics 6: 10.

Hsia, D.A., Lim, S.-T., Bernard-Trifilo, J.A., Mitra, S.K., Tanaka, S., den Hertog, J., Streblow, D.N., Ilic, D., Ginsberg, M.H., Schlaepfer, D.D. (2005) Integrin a4?1 promotes focal adhesion kinase-independent cell motility via a4 cytoplasmic domain-specific activation of c-Src. Mol. Cell. Biol. 25: 9700-9712.

Jopling, C., den Hertog, J. (2005) Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO Rep. 6: 426-431.

Kilic, A., Velic, A., de Windt, L.J., Fabritz, L., Voss, M., Mitko, D., Zwiener, M., Baba, H.A., van Eickels, M., Schlatter, E., Kuhn, M. (2005) Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice. Circulation 112: 2307-2317.

Koudijs, M.J., den Broeder, M.J., Keijser, A., Wienholds, E., Houwing, S., van Rooijen, E.M.H.C., Geisler, R., van Eeden, F.J.M. (2005) The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway. PLoS Genet. 1: e19.

Kuijper, S. (2005) Of hearts and bones: function and regulation of aristaless-related genes. Thesis, Univ. Utrecht, pp. 1-104.

Kuijper, S., Beverdam, A., Kroon, C., Brouwer, A., Candille, S., Barsh, G., Meijlink, F. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132: 1601-1610.

Kuijper, S., Feitsma, H., Sheth, R., Korving, J., Reijnen, M., Meijlink, F. (2005) Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh. Dev. Biol. 285: 533-544.

Laoukili, J., Kooistra, M.R.H., Brás, A., Kauw, J., Kerkhoven, R.M., Morrison, A., Clevers, H., Medema, R.H. (2005) FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat. Cell Biol. 7: 126-136.

Liu, F., van den Broek, O., Destree, O., Hoppler, S. (2005) Distinct role for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/?-catenin signalling in mesoderm development. Development 132: 5375-5385.

May, R.C., Plasterk R.H.A. (2005) RNA interference spreading in C. elegans. In: Methods in Enzymology vol. 392, RNA interference. Eds. Abelson, J.N., Simon, M.I., San Diego, Elsevier Academic Press, pp. 308-315.

McNulty, C.L., Peres, J.N., Bardine, N., van den Akker, W.M.R., Durston, A.J. (2005) Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects. Development 132: 2861-2871.

Monteiro, R. (2005) Canonical BMP signalling in vertebrates: lessons from mice and fish. Thesis, Univ. Utrecht, pp. 1-127.

Moore, J.C., van Laake, L.W., Braam, S.R., Xue, T., Tsang, S.-Y., Ward, D., Passier, R., Tertoolen, L.L., Li, R.A., Mummery, C.L. (2005) Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies. Reprod. Toxicol. 20: 377-391.

Mummery, C.L. (2005) Solace for the broken-hearted? Nature 433: 585-587.

Oh, M., Rybkin, I.I., Copeland, V., Czubryt, M.P., Shelton, J.M., van Rooij, E., Richardson, J.A., Hill, J.A., de Windt, L.J., Bassel-Duby, R., Olson, E.N., Rothermel B.A. (2005) Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol. Cell. Biol. 25: 6629-6638.

Parlakian, A., Charvet, C., Escoubet, B., Mericskay, M., Molkentin, J.D., Gary-Bobo, G., de Windt, L.J., Ludosky, M.-A., Paulin, D., Daegelen, D., Tuil, D., Li., Z. (2005) Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation 112: 2930-2939.

Passier, R., Mummery, C. (2005) Cardiomyocyte differentiation from embryonic and adult stem cells. Curr. Opin. Biotechnol. 16: 498-502.

Passier, R., Ward-van Oostwaard, D., Snapper, J., Kloots, J., Hassink, R.J., Kuijk, E., Roelen, B., Brutel de la Rivière, A., Mummery, C. (2005) Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells 23: 772-780.

Pellis-van Berkel, W., Verheijen, M.H., Cuppen, E., Asahina, M., de Rooij, J., Jansen, G., Plasterk, R.H., Bos, J.L., Zwartkruis, F.J. (2005) Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Mol. Biol. Cell 16: 106-116.

Peres, J. (2005) Divide and conquer: segmentation and patterning of the anteroposterior axis. Thesis, Univ. Utrecht, pp. 1-130.

Pinto, D., Clevers, H. (2005) Wnt control of stem cells and differentiation in the intestinal epithelium. Exp. Cell Res. 306: 357-363.

Pinto, D., Clevers, H. (2005) Wnt, stem cells and cancer in the intestine. Biol. Cell 97: 185-196.

Pothof, J. (2005) DNA damage responses in Caenorhabditis elegans. Thesis, Univ. Utrecht, pp. 1-122.

Radtke, F., Clevers, H. (2005) Self-renewal and cancer of the gut: two sides of a coin. Science 307: 1904-1909.

Reya, T., Clevers, H. (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.

Riedl, J.A., Brandt, D.T., Batlle, E., Price, L.S., Clevers, H., Bos, J.L. (2005) Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. Biochem. J. 389: 465-469.

Robert, V.J.P., Sijen, T., van Wolfswinkel, J., Plasterk, R.H.A. (2005) Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev. 19: 782-787.

Sansom, O.J., Reed, K.R., van de Wetering, M., Muncan, V., Winton, D.J., Clevers, H., Clarke, A.R. (2005) Cyclin D1 is not an immediate target of ?-catenin following Apc loss in the intestine. J. Biol. Chem. 280: 28463-28467.

Schreurs, R.H.M.M., Sonneveld, E., van der Saag, P.T., van der Burg, B., Seinen, W. (2005) Examination of the in vitro (anti)estrogenic, (anti)androgenic and (anti)dioxin-like activities of tetralin, indane and isochroman derivatives using receptor-specific bioassays. Toxicol. Lett. 156: 261-275.

Smits, B.M.G. (2005) Natural and induced genetic variation in the rat. Thesis, Univ. Utrecht, pp. 1-128.

Smits, B.M.G., Guryev, V., Zeegers, D., Wedekind, D., Hedrich, H.J., Cuppen, E. (2005) Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. BMC Genomics 6: 170-179.

Smits, B.M.G., Peters, T.A., Mul, J.D., Croes, H.J., Fransen, J.A.M., Beynon, A.J., Guryev, V., Plasterk, R.H.A., Cuppen, E. (2005) Identification of a rat model for Usher syndrome type 1B by N-Ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics 170: 1887-1896.

Staal, F.J.T., Clevers, H.C. (2005) WNT signalling and haematopoiesis: a WNT-WNT situation. Nat. Rev. Immunol. 5: 21-31.

Tops, B.B.J., Tabara, H., Sijen, T., Simmer, F., Mello, C.C., Plasterk, R.H.A., Ketting, R.F. (2005) RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Nucleic Acids Res. 33: 347-355.

Vaes, B.L.T., Dechering, K.J., van Someren, E.P., Hendriks, J.M.A., van de Ven, C.J.J.M., Feijen, A., Mummery, C.L., Reinders, M.J.T., Olijve, W., van Zoelen, E.J.J., Steegenga, W.T. (2005) Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone 36: 803-811.

Valdimarsdottir, G., Mummery, C. (2005) Functions of the TGFß superfamily in human embryonic stem cells. APMIS 113: 773-789.

van den Driesche, S. (2005) Molecular and cellular mechanisms underlying hereditary hemorrhagic telangiectasia. Thesis, Univ. Utrecht, pp. 1-142.

van de Stolpe, A., van den Brink, S., van Rooijen, M., Ward-van Oostwaard, D., van Inzen, W., Slaper-Cortenbach, I., Fauser, B., van den Hout, N., Weima, S., Passier, R., Smith, N., Denning, C., Mummery, C. (2005) Human embryonic stem cells: towards therapies for cardiac disease. RBM Online 11: 476-485.

van der Wijk, T., Blanchetot, C., den Hertog, J. (2005) Regulation of receptor protein-tyrosine phosphatase dimerization. Methods 35: 73-79.

van der Woude, H., ter Veld, M.G.R., Jacobs, N., van der Saag, P.T., Murk, A.J., Rietjens, I.M.C.M. (2005) The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol. Nutr. Food Res. 49: 763-771.

van Empel, V.P.M., Bertrand, A.T.A., Hofstra, L., Crijns, H.J., Doevendans, P.A., de Windt, L.J. (2005) Myocyte apoptosis in heart failure. Cardiovasc. Res. 67: 21-29.

van Empel, V.P.M., Bertrand, A.T., van der Nagel, R., Kostin, S., Doevendans, P.A., Crijns, H.J., de Wit, E., Sluiter, W., Ackerman, S.L., de Windt, L.J. (2005) Downregulation of apoptosis-inducing factor in Harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ. Res. 96: e92-e101.

van Es, J.H., Clevers, H. (2005) Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol. Med. 11: 496-502.

van Es, J.H., Jay, P., Gregorieff, A., van Gijn, M.E., Jonkheer, S., Hatzis, P., Thiele, A., van den Born, M., Begthel, H., Brabletz, T., Taketo, M.M., Clevers, H. (2005) Wnt signaling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 7: 381-386.

van Es, J.H., van Gijn, M.E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D.J., Radtke, F., Clevers, H. (2005) Notch/?-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435: 959-963.

van Laake, L.W., van Hoof, D., Mummery, C.L. (2005) Cardiomyocytes derived from stem cells. Ann. Med. 37: 499-512.

van Oort, R.J., de Windt, L.J. (2005) TOLL-erating cardiac hypertrophy following pressure overload. Cardiovasc. Res. 68: 178-179.

Wehrens, X.H.T., Lehnart, S.E., Reiken, S., van der Nagel, R., Morales, R., Sun, J., Cheng, Z., Deng, S.-X., de Windt, L.J., Landry, D.W., Marks, A.R. (2005) Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc. Natl. Acad. Sci. 102: 9607-9612.

Wienholds, E. (2005) Reverse genetics and microRNAs in zebrafish. Thesis, Univ. Utrecht, pp. 1-124.

Wienholds, E., Kloosterman, W.P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, H.R., Kauppinen, S., Plasterk, R.H.A. (2005) MicroRNA expression in zebrafish embryonic development. Science 309: 310-311.

Wienholds, E., Plasterk, R.H.A. (2005) MicroRNA function in animal development. FEBS Lett. 579: 5911-5922.

Wilson, M.E., Yang, K.Y., Kalousova, A., Lau, J., Kosaka, Y., Lynn, F.C., Wang, J., Mrejen, C., Episkopou, V., Clevers, H.C., German, M.S. (2005) The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes 54: 3402-3409.

Agronskaia, A.V., Tertoolen, L., Gerritsen, H.C. (2004) Fast fluorescence lifetime imaging of calcium in living cells. J. Biomed. Opt. 9:1230-1237.

Armand, A.-S., de Windt, L.J. (2004) Calcium cycling in heart failure: how the fast became too furious. Cardiovasc. Res. 62: 439-441.

Baas, A.F. (2004) LKB1 a master regulator of cell polarity. Thesis, Univ. Utrecht, pp. 1-80.

Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J., Clevers, H.C. (2004) Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116: 457-466.

Baas, A.F., Smit, L., Clevers, H. (2004) LKB1 tumor suppresor protein: PARtaker in cell polarity. Trends Cell Biol. 14: 312-319.

Babiker, F.A., de Windt, L.J., van Eickels, M., Thijssen, V., Bronsaer, R.J.P., Grohé, C., van Bilsen, M., Doevendans, P.A. (2004) 17ß-estradiol antagonizes cardiomyocyte hypertrophy by autocrine/paracrine stimulation of a guanylyl cyclase A receptor-cyclic guanosine monophosphate-dependent protein kinase pathway. Circulation 109: 269-276.

Bakkers, J. Kramer, C., Pothof, J., Quaedvlieg, N.E.M., Spaink, H.P., Hammerschmidt, M. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131: 527-537.

Berezikov, E., Bargmann, C., Plasterk, R.H.A. (2004) Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res. 32: e40.

Berezikov, E., Guryev, V., Plasterk R.H.A., Cuppen, E. (2004) CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res. 14: 170-178.

Blache, P., van de Wetering, M., Duluc, I., Doman, C., Berta, P., Freund, J.N., Clevers, H., Jay, P. (2004) SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J. Cell Biol. 166: 37-47.

Blacque, O.E., Reardon, M.J., Li, C., McCarthy, J., Mahjoub, M.R., Ansley, S.J., Badano, J.L., Mah, A.K., Beales, P.L., Davidson, W.S., Johnsen, R.C., Audeh, M., Plasterk, R.H.A., Baillie, D.L., Katsanis, N., Quarmby, L.M., Wicks, S.R., Leroux, M.R. (2004) Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 18: 1630-1642.

Boersma-Vreugdenhil, G.R., Kuipers, J., van Stralen, E., Peeters, T., Michaux, L., Hagemeijer, A., Pearson, P.L., Clevers, H.C., Bast, B.J.E.G. (2004) The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint. Br. J. Haemotol. 126: 355-363.

Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M., Birchmeier, W. (2004) Essential role of BCL9-2 in the switch between ß-catenin's adhesive and transcriptional functions. Genes Dev. 18: 2225-2230.

Candille, S.I., van Raamsdonk, C.D., Chen, C., Kuijper, S., Chen-Tsai, Y., Russ, A., Meijlink, F., Barsh, G.S. (2004) Dorsoventral patterning of the mouse coat by Tbx15. PLoS Biol. 2: 30-42.

Carvalho, R. (2004) TGFß signaling, endoglin and vascular development in mice. Thesis, Univ. Utrecht, pp 1-128.

Carvalho, R., Jonker, L., Goumans, M.J., Larsson, J., Bouwman, P., Karlsson, S., ten Dijke, P., Arthur, H., Mummery, C. (2004) Defective paracrine signaling by TGFß in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary hemorrhagic telangiectasia. Development 131: 6237-6247.

Chawengsaksophak, K., de Graaff, W., Rossant, J., Deschamps, J., Beck, F. (2004) Cdx2 is essential for axial elongation in mouse development. Proc. Natl. Acad. Sci. 101: 7641-7645.

Chuva de Sousa Lopes, S.M. (2004) BMPs, TGFßs and integrins in muscle and germ cell development in mice. Thesis, Univ. Utrecht, pp 1-105.

Chuva de Sousa Lopes, S.M., Feijen, A., Korving, J., Korchynskyi, O., Larsson, J., Karlsson, S., ten Dijke, P., Lyons, K.M., Goldschmeding, R., Doevendans, P., Mummery, C.L. (2004) Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev. Dyn. 231: 542-550.

Chuva de Sousa Lopes, S.M., Mummery, C.L. (2004) Differentiation in early development. In: Handbook of Stem Cells, volume 1, Embryonic Stem Cells. Ed. Lanza, R., San Diego, Elsevier Academic Press, pp. 143-156.

Chuva de Sousa Lopes, S.M., Roelen, B.A.J., Monteiro, R.M., Emmens, R., Lin, H.Y., Li, E., Lawson, K.A., Mummery, C.L. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 18: 1838-1849.

Clevers, H. (2004) At the crossroads of inflammation and cancer. Cell 118: 671-674.

Clevers, H. (2004) Signaling mucins in the (s)limelight. Dev. Cell 7: 150-151.

Clevers, H. (2004) Wnt signaling: Ig-Norrin the dogma. Curr. Biol. 14: R436-R437.

de Jong, D.S., Vaes, B.L.T., Dechering, K.J., Feijen, A., Hendriks, J.M.A., Wehrens, R., Mummery, C.L., van Zoelen, E.J.J., Olijve, W., Steenenga, W.T. (2004) Identification of novel regulators associated with early-phase osteoblast differentiation. J. Bone Miner. Res. 19: 947-958.

de Windt, L.J., Doevendans, P.A., Chien, K.R. (2004) Generation and cloning of genetically modified animals. In: The molecular basis of cardiovascular disease, 2nd edition - a companion to Braunwald’s heart disease. Ed. Chien K.R., Philadelphia, PA, USA, W.B. Saunders Co., pp. 49-71.

den Hertog, J. (2004) Receptor protein tyrosine phosphatases. Topics in Current Genetics 5: 253-274.

Denli, A.M., Tops, B.B.J., Plasterk, R.H.A., Ketting, R.F., Hannon, G.J. (2004) Processing of primary microRNAs by the microprocessor complex. Nature 432: 231-235.

Derksen, P.W.B., Tjin, E., Meijer, H.P., Klok, M.D., MacGillavry, H.D., van Oers, M.H.J., Lokhorst, H.M., Bloem, A.C., Clevers, H., Nusse, R., van der Neut, R., Spaargaren, M., Pals, S.T. (2004) Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc. Natl. Acad. Sci.: 101: 6122-6127.

Deschamps, J. (2004) Hox genes in the limb: a plan in two acts. Science 304: 1610-1611.

Doevendans, P.A., Chien, K., Mummery C.L. (2004) Towards stem cell therapy. In: The molecular basis of cardiovascular disease, 2nd edition - a companion to Braunwald’s heart disease. Ed. Chien K.R., Philadelphia, PA, USA, W.B. Saunders Co., pp. 107-122.

Duboule, D., Deschamps, J. (2004) Colinearity loops out. Dev. Cell 6: 738-740.

Fahnert, B., Veijola, J., Roël, G., Kärkkäinen, M.K., Railo, A., Destrée, O., Vainio, S., Neubauer, P. (2004) Murine Wnt-1 with an internal c-myc tag recombinantly produced in Escherichia coli can induce intracellular signaling of the canonical Wnt pathway in eukaryotic cells. J. Biol. Chem. 279: 47520-47527.

Gregorieff, A., Grosschedl, R., Clevers, H. (2004) Hindgut defects and transformation of the gastro-intestinal tract in Tcf4-/-/Tcf1-/- embryos. EMBO J. 23: 1825-1833.

Guryev, V., Berezikov, E., Malik, R., Plasterk, R.H.A., Cuppen, E. (2004) Single Nucleotide Polymorphisms associated with rat expressed sequences. Genome Res. 14: 1438-1443.

Haramis, A.-P.G., Begthel, H., van den Born, M., van Es, J., Jonkheer, S., Offerhaus, G.J.A., Clevers, H. (2004) De novo crypt formation and juvenile polyposis upon BMP inhibition in mouse intestine. Science 303: 1684-1686.

Hassink, R.J., Goumans, M.J., Mummery, C.L., Doevendans, P.A. (2004) Human stem cells shape the future of cardiac regeneration research. Int. J. Cardiol. 95: s20-s22.

Hassink, R.J., Passier, R., Goumans, M.J., Mummery, C.L., Doevendans, P.A. (2004) New and viable cells to replace lost and malfunctioning myocardial tissue. Minerva Cardioangiol. 52: 433-445.

Heringa, M.B., Schreurs, R.H.M.M., Busser, F., van der Saag, P.T., van der Burg, B., Hermens, J.L.M. (2004) Toward more useful in vitro toxicity data with measured free concentrations. Environ. Sci. Technol. 38: 6263-6270.

Hilliard, M.A., Bergamasco, C., Arbucci, S., Plasterk, R.H.A., Bazzicalupo, P. (2004) Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. Embo J. 23: 1101-1111.

In der Rieden, P.M.J., Mainguy, G., Woltering, J.M., Durston, A.J. (2004) Homeodomain to hexapeptide or PBC-interaction-domain distance: size apparently matters. Trends Genet. 20: 76-79.

Kennedy, B.N., Stearns, G.W., Smyth, V.A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J.B., Brockerhoff, S.E. (2004) Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Dev. Biol. 270: 336-349.

Ketting, R.F., Plasterk, R.H.A. (2004) What’s new about RNAi? Meeting on siRNAs and miRNAs. EMBO Rep. 5, 762-765.

Kikuchi, T., Ichimiya, S., Kojima, T., Crisa, L., Koshiba, S., Tonooka, A., Kondo, N., van der Saag, P.T., Yokoyama, S., Sato, N. (2004) Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes. Int. Immunol. 16: 831-841.

Kloosterman, W.P., Wienholds, E., Ketting, R.F., Plasterk, R.H.A. (2004) Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res. 32: 6284-6291.

Koch, R., Rauch, G.J., Humphray, S., Geisler, T.R., Plasterk, R.H.A. (2004) Bacterial artificial chromosome (BAC) clones and the current clone map of the zebrafish genome. In: Detrich III, H.W., Westerfield, M., Zon, L.I. (eds) Methods in Cell Biology 77; The Zebrafish: 2nd edition Genetics, Genomics & Informatics, San Diego, Elsevier Academic Press, pp. 295-304.

Le, N.H., van der Bent, P., Huls, G., van de Wetering, M., Loghman-Adham, M., Ong, A.C.M., Calvet, J.P., Clevers, H., Breuning, M.H., van Dam, H., Peters, D.J.M. (2004) Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected. J. Biol. Chem. 279: 27472-27481.

Lebrin, F., Goumans, M.J., Jonker, L., Carvalho, R.L.C., Valdimarsdottir, G., Thorikay, M., Mummery, C., Arthur, H.M., ten Dijke, P. (2004) Endoglin promotes endothelial cell proliferation and TGF-ß/ALK1 signal transduction. EMBO J. 23: 4018-4028.

Lemmen, J.G., Arends R.J., van Boxtel, A.L., van der Saag, P.T., van der Burg, B. (2004) Tissue- and time-dependent estrogen receptor activation in estrogen reporter mice. J. Mol. Endocrinol. 32: 689-701.

Lemmen, J.G., Arends, R.J., van der Saag, P.T., van der Burg, B. (2004) In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A. Environ. Health Perspect. 112: 1544-1549.

Lima, F., Vico, L., Lafage-Proust, M.-H., van der Saag, P., Alexandre, C., Thomas, T. (2004) Interactions between estrogen and mechanical strain effects on U2OS human osteosarcoma cells are not influenced by estrogen receptor type. Bone 35: 1127-1135.

Lips, D.J., Bueno, O.F., Wilkins, B.J., Purcell, N.H., Kaiser, R.A., Lorenz, J.N., Voisin, L., Saba-El-Leil, M.K., Meloche, S., Pouysségur, J., Pagès, G., de Windt, L.J., Doevendans, P.A., Molkentin, J.D. (2004) MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation 109: 1938-1941.

Lips, D.J., van der Nagel, Th., Steendijk, P., Palmen, M., Janssen, B.J., van Dantzig, J.-M., de Windt, L.J., Doevendans, P.A. (2004) Left ventricular pressure-volume measurements in mice: comparison of closed-chest versus open-chest approach. Basic Res. Cardiol. 99: 351-359.

Lorber, B., Berry, M., Hendriks, W., den Hertog, J., Pulido, R., Logan, A. (2004) Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPa, STEP, and LAR. Mol. Cell. Neurosci. 27: 404-416.

Monteiro, R.M., Chuva de Sousa Lopes, S.M., Korchynskyi, O., ten Dijke, P., Mummery, C.L. (2004) Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins. J. Cell Sci. 117: 4653-4663.

Moore, J.C., Spijker, R., Martens, A.C., de Boer, T. Rook, M.B., van der Heyden, M.A.G., Tertoolen, L.G., Mummery, C.L. (2004) A P19Cl6 GFP reporter line to quantify cardiomyocyte differentiation of stem cells. Int. J. Dev. Biol. 48: 47-55.

Morgan, M.J., Woltering, J.M., In der Rieden, P.M.J., Durston, A.J., Thiery, J.P. (2004) YY1 regulates the neural crest-associated slug gene in Xenopus laevis. J. Biol. Chem. 279: 46826-46834.

Mummery, C. (2004) Stem cell research: immortality or a healthy old age? Eur. J. Endocrinol. 151, suppl. 3: U7-U12.

Nollen, E.A.A., Garcia, S.M., van Haaften, G., Kim, S., Chavez, A., Morimoto, R.I., Plasterk, R.H.A. (2004) Genome-wide RNAi screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. 101: 6403-6408.

Oosterveen, T., Meijlink, F., Deschamps, J. (2004) Expression of retinaldehyde dehydrogenase II and sequential activation of 5' Hoxb genes in the mouse caudal hindbrain. Gene Expr. Patterns 4: 243-247.

Palmen, M., Daemen, M.J.A.P., de Windt, L.J., Willems, J., Dassen, W.R.M., Heeneman, S., Zimmermann, R., van Bilsen, M., Doevendans, P.A. (2004) Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. J. Am. Coll. Cardiol. 44: 1113-1123.

Pera, M.F., Andrade, J., Houssami, S., Reubinoff, B., Trounson, A., Stanley, E.G., Ward-van Oostwaard, D., Mummery, C. (2004) Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J. Cell Science 117: 1269-1280.

Persson, C., Sjöblom, T., Groen, A., Kappert, K., Engström, U., Hellman, U., Heldin, C.H., den Hertog, J., Östman, A. (2004) Preferential oxidation of the second phosphatase domain of receptor-like PTP-a revealed by an antibody against oxidized protein tyrosine phosphatases. Proc. Natl. Acad. Sci. 101: 1886-1891.

Rentzsch, F., Bakkers, J., Kramer, C., Hammerschmidt, M. (2004) Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Dev. Dyn. 231: 750-757.

Robert, V.J.P., Vastenhouw, N.L., Plasterk, R.H.A. (2004) RNAi, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences. In: Cold Spring Harbor Symposia on Quantitative Biology, symposium 69, pp. 397-402.

Sancho, E., Batlle, E., Clevers, H. (2004) Signaling pathways in intestinal development and cancer. Annu. Rev. Cell Dev. Biol. 20: 695-723.

Sansom, O.J., Reed, K.R., Hayes, A.J., Ireland, H., Brinkmann, H., Newton, I.P., Batlle, E. Simon-Assmann, P., Clevers, H., Nathke, I.S., Clarke, A.R., Winton, D.J. (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18: 1385-1390.

Simmer, F., Plasterk, R.H.A. (2004) RNAi in Caenorhabditis elegans. In: Sohail, M. (ed) Gene silencing by RNA interference: technology and application. London, Taylor & Francis, pp. 167-182.

Smit, L., Baas, A., Kuipers, J., Korswagen, H., van de Wetering, M., Clevers, H. (2004) Wnt activates the Tak1/Nemo-like kinase pathway. J. Biol. Chem. 279: 17232-17240.

Smits, B.M.G., d’Souza, U.M., Berezikov, E., Cuppen, E., Sluyter, F. (2004) Identifying polymorphisms in the Rattus norvegicus D3 dopamine receptor gene and regulatory region. Genes Brain Behav. 3: 138-148.

Smits, B.M.G., Mudde, J., Plasterk, R.H.A., Cuppen E. (2004) Target-selected mutagenesis of the rat. Genomics 83: 332-334

Smits, B.M.G., van Zutphen, B.F.M., Plasterk, R.H.A., Cuppen, E. (2004) Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res. 14: 1285-1290.

Spieker, N., Peterson, J., Reneman, S., Destrée, O. (2004). Analysis of the Tcf-3 promoter during early development of Xenopus. Dev. Dyn. 231: 510-517.

Tijsterman, M., May, R.C., Simmer, F., Okihara, K.L., Plasterk, R.H.A. (2004) Genes required for systemic RNA interference in Caenorhabditis elegans. Curr. Biol.14: 111-116.

Tijsterman, M., Plasterk, R.H.A. (2004) Dicers at RISC: the mechanism of RNAi. Cell 117: 1-4.

van Empel, V.P.M., de Windt, L.J. (2004) Myocyte hypertrophy and apoptosis: a balancing act. Cardiovasc. Res. 63: 487-499.

van Haaften, G., Plasterk, R.H.A., Tijsterman, M. (2004) Genomic instability and cancer: scanning the Caenorhabditis elegans genome for tumor suppressors. Oncogene 23: 8366-8375.

van Haaften, G., Vastenhouw, N.L., Nollen, E.A.A., Plasterk, R.H.A., Tijsterman, M. (2004) Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc. Natl. Acad. Sci. 101: 12992-12996.

van Rooij, E., Doevendans, P.A., Crijns, H.J.M.G., Heeneman, S., Lips, D.J., van Bilsen, M., Williams, R.S., Olson, E.N., Bassel-Duby, R., Rothermel, B.A., de Windt, L.J. (2004) MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction. Circ. Res. 94: 18-26.

van de Stolpe, A., Slycke, A.J., Reinders, M.O., Zomer, A.W.M., Goodenough, S., Behl, C., Seasholtz, A.F., van der Saag, P.T. (2004) Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERa and ERß. Mol. Endocrinol. 18: 2908-2923.

van der Wijk, T., Overvoorde, J., den Hertog, J. (2004) H2O2 induced intermolecular disulfide bond formation between receptor protein-tyrosine phosphatases. J. Biol. Chem. 279: 44355-44361.

van der Horst, A., Tertoolen, L.G.J., de Vries-Smits, L.M.M., Frye, R.A., Medema, R.H., Burgering, B.M.T. (2004) FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1. J. Biol. Chem. 279: 28873-28879.

van der Linden, A.M., Plasterk, R.H.A. (2004) Shotgun cloning of transposon insertions in the genome of Caenorhabditis elegans. Comp. Funct. Genom. 5: 225-229.

Vastenhouw, N., Plasterk R.H.A. (2004) RNAi protects the Caenorhabditis elegans germline against transposition. Trends Genet. 20: 314-319.

von der Thusen, J.H., Fekkes, M.L., Passier, R., van Zonneveld A.J., Mainfroid, V., van Berkel, T.J.C., Biessen, E.A.L. (2004) Adenoviral transfer of endothelial nitric oxide synthase attenuates lesion formation in a novel murine model of postangioplasty restenosis. Arterioscler. Thromb. Vasc. Biol. 24: 357-362.

Vrljicak, P., Myburgh, D., Ryan, A.K., van Rooijen, M.A., Mummery, C.L., Gupta, I.R. (2004) Smad expression during kidney development. Am. J. Physiol. Renal. Physiol. 286: 625-633.

Wacker, S.A., Jansen, H.J., McNulty, C.L., Houtzager, E., Durston, A.J. (2004) Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation. Dev. Biol. 268: 207-219.

Wacker, S.A., McNulty, C.L., Durston, A.J. (2004) The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4. Dev. Biol. 266: 123-137.

Wienholds, E., Plasterk, R.H.A. (2004) Target-selected gene inactivation in zebrafish. In: Detrich III, H.W., Westerfield, M., Zon, L.I. (eds) Methods in Cell Biology 77; The Zebrafish: 2nd edition Genetics, Genomics & Informatics, San Diego, Elsevier Academic Press, pp. 69-90.

Agronskaia, A.V., Tertoolen, L., Gerritsen, H.C. (2003) High frame rate fluorescence lifetime imaging. J. Phys. D: Appl. Phys. 36: 1655-1662.

Althini, S., Bengtsson, H., Usoskin, D., Söderström, S., Kylberg, A., Lindqvist, E., Chuva de Sousa Lopes, S., Olson, L., Lindeberg, J., Ebendal, T. (2003) Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles. J. Neurosci. Res. 72: 444-453.

Baas, A.F., Boudeau, J., Sapkota, G.P., Smit, L., Medema, R., Morrice, N.A., Alessi, D.R., Clevers, H.C. (2003) Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. Embo J. 22: 3062-3072.

Beltrán-Valero de Bernabé, D., van Bokhoven, H., van Beusekom, E., van den Akker, W., Kant, S., Dobyns, W.B., Cormand, B., Currier, S., Hamel, B., Topaloglu, H., Brunner, H.G. (2003) A homozygous nonsense mutation in the Fukutin gene causes a Walker-Walburg syndrome phenotype. J. Med. Genet. 40: 845-848.

Bienz, M., Clevers, H. (2003) Armadillo/ß-catenin signals in the nucleus-proof beyond a reasonable doubt? Nature Cell Biol. 5: 179-182.

Bink, R.J., Habuchi, H., Lele, Z., Dolk, E., Joore, J., Rauch, G.-J., Geisler, R., Wilson, S.W., den Hertog, J., Kimata, K., Zivkovic, D. (2003) Heparan sulphate 6-O-sulfotransferase is essential for muscle development in zebrafish. J. Biol. Chem. 278: 31118-31127.

Bird, S.D., Doevendans, P.A., van Rooijen, M.A., Brutel de la Rivière, A., Hassink, R.J., Passier, R., Mummery, C.L. (2003) The human adult cardiomyocyte phenotype. Cardiovasc. Res. 58: 423-434.

Boudeau, J., Baas, A.F., Deak, M., Morrice, N.A., Kieloch, A., Schutkowski, M., Prescott, A.R., Clevers, H.C., Alessi, D.R. (2003) MO25a/ß interact with STRADAa/ß enhancing their ability to bind, activate and localise LKB1 in the cytoplasm. Embo J. 22: 5102-5114.

Brantjes, H. Wnt signaling: activation, repression and fine-tuning of TCF transcription factors. University of Utrecht, 2003.

Brinkmeier, M.L., Potok, M.A., Cha, K.B., Gridley, T., Stifani, S., Meeldijk, J., Clevers, H., Camper, S.A. (2003) TCF and Groucho-related genes influence pituitary growth and development. Mol. Endocrinol. 17: 2152-2161.

Brouwer, A., ten Berge, D., Wiegerinck, R., Meijlink, F. (2003) The OAR/aristaless domain of the homeodomain protein Cart1 has a attenuating role in vivo. Mech. Dev. 120: 241-252.

Bucher, E., Sijen, T., de Haan, P., Goldbach, R., Prins, M. (2003) Negative-strand tospoviruses and tenuiviruses carry a gene for a suppressor of gene silencing at analogous genomic positions. J. Virol. 77: 1329-1336.

Cachaço, A.S., Chuva de Sousa Lopes, S.M., Kuikman, I., Bajanca, F., Abe, K., Baudoin, C., Sonnenberg, A., Mummery, C.L., Thorsteinsdóttir, S. (2003) Knock-in of integrin ß1D affects primary but not secondary myogenesis in mice. Development 130: 1659-1671.

Caudy, A.A., Ketting, R.F., Hammond, S.M., Denli, A.M., Bathoorn, A.M.P., Tops, B.B.J., Silva, J.M., Myers, M.M., Hannon, G.J., Plasterk, R.H.A. (2003) A micrococcal nuclease homolog in RNAi effector complexes. Nature 425: 411-414.

Chuva de Sousa Lopes, S.M., Carvalho, R.L.C., van den Driesche, S., Goumans, M.-J., ten Dijke, P., Mummery, C.L. (2003) Distribution of phosphorylated Smad2 identifies target tissues of TGFß ligands in mouse development. Gene Expr. Patterns 3: 355-360.

Clevers, H. (2003) Thymocyte development: drama without Brahma. Immunity 19: 157-158.

Cuppen, E., van der Linden, A.M., Jansen, G., Plasterk, R.H.A. (2003) Proteins interacting with Caenorhabditis elegans G-alpha subunits. Comp. Funct. Genomics 4: 479-491.

de Graaff, W., Tomotsune, D., Oosterveen, T., Takihara, Y., Koseki, H., Deschamps, J. (2003) Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants. Proc. Natn. Acad. Sci. 100: 13362-13367.

de Wert, G., Mummery, C.L. (2003) Human embryonic stem cells: research, ethics and policy. Human Reprod. 18: 672-682.

de Windt, L.J., Doevendans, P.A. (2003) Fatty acid homeostasis as a modulator of cardiac disease. In: Recent Res. Devel. Biophy. Biochem. Ed. Pandalai, S.G. Kerala, India, Research Signpost 3, pp. 547-568.

den Hertog, J., van der Wijk, T., Tertoolen, L.G.J., Blanchetot, C. (2003) Receptor protein-tyrosine phosphatase dimerization. Meth. Enzymol. 366: 224-240.

den Hertog, J. (2003) Regulation of protein phosphatases in disease and behavior. Embo Rep. 4: 1027-1032.

Defize, B. (2003) Stamcellen. Niche 34: 6-9.

Feiters, M.C., Eijkelenboom, A.P.A.M., Nolting, H.-F., Krebs, B., van den Ent, F.M.I., Plasterk, R.H.A., Kaptein, R., Boelens, R. (2003) X-ray absorption spectroscopic studies of zinc in the N-terminal domain of HIV-2 integrase and model compounds. J. Synchrot. Radiat. 10: 86-95.

Fischer, S.E.J., Wienholds, E., Plasterk, R.H.A. (2003) Continuous exchange of sequence information between dispersed Tc1 transposons in the Caenorhabditis elegans genome. Genetics 164: 127-134.

Forlani, S., Lawson, K.A., Deschamps, J. (2003) Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo. Development 130: 3807-3819.

Giles, R.H., van Es, J.H., Clevers, H. (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 1653: 1-24.

Goumans, M.-J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S., ten Dijke, P. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFß/ALK5 signaling. Mol. Cell 12: 817-828.

Hassink, R.J., Brutel de la Rivière, A., Mummery, C.L., Doevendans, P.A. (2003) Transplantation of cells for cardiac repair. J. Amer. Coll. Cardiol. 41: 711-717.

Hassink, R.J., Dowell, J.D., Brutel de la Rivière, A., Doevendans, P.A., Field, L.J. (2003) Stem cell therapy for ischemic heart disease. Trends Mol Med 9: 436-441.

Hassink, R.J., Grosfeld, M.J., Marcelis, C., Delhaas, T., Doevendans, P.A.F.M. (2003) Hypertrofische cardiomyopathie: van diagnostiek naar preventie. Ned. Tijdschr. Geneesk. 147: 1181-1184.

Held, W., Clevers, H., Grosschedl, R. (2003) Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Europ. J. Immunol. 33: 1393-1398.

Horie, K., Yusa, K., Yae, K., Odajima, J., Fischer, S.E.J., Keng, V.W., Hayakawa, T., Mizuno, S., Kondoh, G., Ijiri, T., Matsuda, Y., Plasterk, R.H.A., Takeda, J. (2003) Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol. Cell. Biol. 23: 9189-9207.

Hurlstone, A.F.L., Haramis, A.-P.G., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H.A., Clevers, J.C. (2003) The Wnt/ß-catenin pathway regulates cardiac valve formation. Nature 425: 633-637.

In der Rieden, P.M.J. Control of Hox gene regulation and function during anteroposterior patterning in Xenopus laevis. University of Utrecht, 2003.

Kester, H.A., Sonneveld, E., van der Saag, P.T., van der Burg, B. (2003) Prolonged progestin treatment induces the promoter of CDK-inhibitor p21Cip1,Waf1 through activation of p53 in human breast and endometrial tumor cells. Exp. Cell Res. 284: 262-271.

Ketting, R.F., Tijsterman, M., Plasterk, R.H.A. (2003) RNAi in Caenorhabditis elegans. In: RNAi: a Guide to Gene Silencing. Ed. Hannon, G.J. Cold Spring Harbor, Cold Spring Harbor Press, pp. 65-85.

Kim, P.J., Plescia, J., Clevers, H., Fearon, E.R., Altieri, D.C. (2003) Survivin and molecular pathogenesis of colorectal cancer. Lancet 362: 205-209.

Koop, E.A., Chuva de Sousa Lopes, S.M., Feiken, E., Bluyssen, H.A.R., van der Valk, M., Voest, E.E., Mummery, C.L., Moolenaar, W.H., Gebbink, M.F.B.G. (2003) Receptor protein-tyrosine phosphatase µ expression as a marker for endothelial cell heterogeneity; analysis of RPTPµ gene expression using LacZ knock-in mice. Int. J. Dev. Biol. 47: 345-354.

Krijgsveld, J., Ketting, R.F., Mahmoudi, T., Johansen, J., Artal-Sanz, M., Verrijzer, C.P., Plasterk, R.H.A., Heck, A.J.R. (2003) Metabolic labeling of C. elegans and
D. Melanogaster for quantitative proteomics. Nature Biotechnol. 21: 927-931.

Lips, D.J., de Windt, L.J., van Kraaij, D.J.W., Doevendans P.A. (2003) Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy. Eur. Heart J. 24: 883-896.

Mainguy, G., In der Rieden, P., Berezikov, E., Woltering, J.M., Plasterk, R.H.A., Durston, A.J. (2003) A position-dependent organization of retinoid response elements is conserved in the vertebrate Hox clusters. Trends Genet. 19: 476-479.

Meijlink, F., Kuijper, S., Brouwer, A., Kroon, C. (2003) Prx, Alx and Shox genes in craniofacial and appendicular development. In: Advances in developmental biology and biochemistry vol. 13.: Murine homeobox gene control of embryonic patterning and organogenesis. Ed. Lufkin, T. Amsterdam, Elsevier, pp. 133-153.

Miskey, C., Izsvak, Z., Plasterk, R.H.A., Ivics, Z. (2003) The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells. Nucleic Acids Res. 31: 6873-6881.

Moorman, C. Analysis of diverse signal transduction pathways using the genetic model system Caenorhabditis elegans. University of Utrecht, 2003.

Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H., Taketo, M.M., Behringer, R.R., Shen, M.M., Birchmeier, W. (2003) Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130: 6283-6294.

Mummery, C. (2003) Humane embryonale stamcellen: IVF-technologie onmisbaar bij de ontwikkeling van celtransplantatietherapieën. Tijdschr. Fertiliteitsonderz. 17: 34-41.

Mummery, C., Ward-Van Oostwaard, D., Doevendans, P., Spijker, R., van den Brink, S., Hassink, R., van der Heyden, M., Opthof, T., Pera, M., Brutel de la Rivière, A., Passier, R., Tertoolen, L. (2003) Differentiation of human embryonic stem cells to cardiomyocytes: role of co-culture with visceral endoderm-like cells. Circulation 107: 2733-2740.

Nagy, A., Perrimon, N., Sandmeyer, S., Plasterk, R.H.A. (2003) Tailoring the genome: the power of genetic approaches. Nat. Genet. 33: 276-284.

Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, P., van Noort, M., Hui, C.-c., Clevers, H., Dotto, G.P., Radtke, F. (2003) Notch 1 functions as a tumor suppressor in mouse skin. Nat. Genet. 33: 416-421.

Oosterveen, T., Niederreither, K., Dollé, P., Chambon, P., Meijlink, F., Deschamps, J. (2003) Retinoids regulate the anterior expression boundaries of 5’Hoxb genes in posterior hindbrain. Embo J. 22: 262-269.

Oosterveen, T., van Vliet, P., Deschamps, J., Meijlink, F. (2003) The direct context of a Hox retinoic acid response element is crucial for its activity. J. Biol. Chem. 278: 24103-24107.

Passier, R. (2003) Potential of human embryonic stem cells in regenerative medicine. Horm. Res. 60 suppl. 3: 11-14.

Passier, R., Mummery, C. (2003) Origin and use of embryonic and adult stem cells in differentiation and tissue repair. Cardiovasc. Res. 58: 324-335.

Pinto, D., Gregorieff, A., Begthel, H., Clevers, H. (2003) Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17: 1709-1713.

Pinto, Y.M., de Windt, L.J., van Gilst, W.H. (2003) Pathofysiologische en moleculaire aspecten van hartfalen. In: Leerboek Hartfalen. Eds. Veldhuizen, D.J., Voors, A.A. Leusden, Mediselect, pp. 11-25.

Pothof, J., van Haaften, G., Thijssen, K., Kamath, R.S., Fraser, A.G., Ahringer, J., Plasterk, R.H.A., Tijsterman, M. (2003) Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev. 17: 443-448.

Raich, W.B., Moorman, C., Lacefield, C.O., Lehrer, J., Bartsch, D., Plasterk, R.H.A., Kandel, E.R., Hobert, O. (2003) Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Genetics 163: 571-580.

Roël, G. Tcf/Lef transcription factors in Xenopus development. University of Utrecht, 2003.

Roël, G., van den Broek, O., Spieker, N., Peterson-Maduro, J., Destrée, O. (2003) Tcf-1 expression during Xenopus development. Gene Expr. Patterns 3: 123-126.

Sancho, E., Batlle, E., Clevers, H. (2003) Live and let die in the intestinal epithelium. Curr. Opin. Cell Biol. 6: 763-770.

Simmer, F. RNA interference in Caenorhabditis elegans; mechanism and application. University of Utrecht, 2003.

Simmer, F., Moorman, C., van der Linden, A.M., Kuijk, E., van den Berghe, P.V.E., Kamoth, R.S., Fraser, A.G., Ahringer, J., Plasterk, R.H.A. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS
Biol. 1: 77-84.

Sijen, T., Plasterk, R.H.A. (2003) Transposon silencing in the Caenorhabditis elegans germ by natural RNAi. Nature 426: 310-314.

Staal, F.J., Clevers, H.C. (2003) Wnt signaling in the thymus. Curr. Op. Immunol. 15: 204-208.

Toledano-Katchalski, H., Tiran, Z., Sines, T., Shani, G., Granot-Attas, S., den Hertog, J., Elson, A. (2003) Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase Epsilon. Mol. Cell. Biol. 23: 5460-5471.

van de Wetering, M., Oving, I., Muncan, V., Pon Fong, M.T., Brantjes, H., van Leenen, D., Holstege, F.C., Brummelkamp, T.R., Agami, R., Clevers, H. (2003) Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. Embo Rep. 4: 609-615.

van den Berg, M.P., Hassink, R.J., Balje-Volkers, C., Crijns, H.J. (2003) Role of the autonomic nervous system in vagal atrial fibrillation. Heart 89: 333-335.

van den Driesche, S., Mummery, C.L., Westermann, C.J. (2003) Hereditary hemorrhagic telangiectasia: an update on transforming growth factor ß signaling in vasculogenesis and angiogenesis. Cardiovasc. Res. 58: 20-31.

van der Heyden, M.A.G., Defize, L.H.K. (2003) Twenty one years of P19 cells: what an embryonal carcinoma cell line taught us about cardiomyocyte differentiation. Cardiovasc. Res. 58: 292-302.

van der Heyden, M.A.G., Hescheler, J., Mummery, C.L. (2003) Spotlight on stem cells - makes old hearts fresh. Cardiovasc. Res. 58: 241-245.

van der Linden, A.M. G-protein signaling pathways in Caenorhabditis elegans that control behavior and development. University of Utrecht, 2003.

van der Linden, A.M., Moorman, C., Cuppen, E., Korswagen, H.C., Plasterk, R.H.A. (2003) Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr. Biol. 13: 516-521.

van der Sar, A.M., Musters, R.J., van Eeden, F.J.M., Appelmelk, B.J., Vandenbroucke-Grauls, C.M.J.E., Bitter, W. (2003) Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections. Cell. Microbiol. 5: 601-611.

van der Wijk, T., Blanchetot, C., Overvoorde, J., den Hertog, J. (2003) Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase a dimers. J. Biol. Chem. 278: 13968-13974.

van Empel, V.P.M., de Windt L.J. (2003) Human heart failure: our current STATus of knowledge. Cardiovasc. Res. 57: 294-297.

van Es, J.H., Barker, N., Clevers, H. (2003) You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr. Op. Genet. Dev. 13: 28-33.

Vastenhouw, N.L., Fischer, S.E.J., Robert, V.J.P., Thijssen, K.L., Fraser, A.G., Kamath, R.S., Ahringer, J., Plasterk, R.H.A. (2003) A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr. Biol. 13: 1311-1316.

Verbrugge, A., de Ruiter, T., Clevers, H., Meyaard, L. (2003) Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. Int. Immunol. 15: 1349-1358.

Vermeer, H., Hendriks-Stegeman, B.I., van den Brink, C.E., van der Saag, P.T., van der Burg, B., van Buul-Offers, S.C., Jansen, M. (2003) A novel specific bioassay for the determination of glucocorticoid bioavailability in human serum. Clin. Endocrinol. (Oxf) 59: 49-55.

Vermeer, H., Hendriks-Stegeman, B.I., van der Burg, B., van Buul-Offers, S.C., Jansen, M. (2003) Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J. Clin. Endocrinol. Metab. 88: 277-284.

Voncken, J.W., Roelen, B.A.J., Roefs, M., de Vries, S., Verhoeven, E., Marino, S., Deschamps, J., van Lohuizen, M. (2003) Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc. Natn. Acad. Sci. 100: 2468-2473.

White, P., Thomas, D.W., Fong, S., Stelnicke, E., Meijlink, F., Largman, C., Stephens, P. (2003) Deletion of the homeobox gene Prx-2 affects fetal but not adult fibroblast wound healing responses. J. Invest. Dermatol. 120: 135-144.

Wienholds, E., van Eeden, F., Kosters, M., Mudde, J., Plasterk, R.H.A., Cuppen, E. (2003) Efficient target-selected mutagenesis in zebrafish. Genome Res. 13: 2700-2707.

Wienholds, E., Koudijs, M.J., van Eeden, F.J.M., Cuppen, E., Plasterk, R.H.A. (2003) The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat. Genet. 35: 217-218.

Zomer, A.W.M., van der Saag, P.T., Poll-The, B.T. (2003) Phytanic acid and pristanic acid are naturally occurring ligands. In: Peroxisomal disorders and regulation of genes. Eds. Roels, F., Baes, M., de Bie, S. Kluwer New York, Academic/Plenum Publ., pp. 247-254.

Berezikov, E., Plasterk, R.H.A. and Cuppen, E. GENOTRACE: cDNA-based local GENOme assembly from TRACE archives. Bioinformatics 18: 1396-1397, 2002.

Bink, R. Embryonic development of the zebrafish central nervous system. Thesis, Univ. Utrecht, pp. 1-160, 2002.

Blanchetot, C., Tertoolen, L.G.J. and Den Hertog, J. Regulation of receptor protein-tyroxine phosphatase a by oxidative stress. Embo J. 21: 493-503, 2002.

Blanchetot, C., Tertoolen, L.G.J., Overvoorde, J. and Den Hertog, J. Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J. Biol. Chem. 277: 47263-47269, 2002.

Carvalho, R.L.S., Driessens, M.H.E. and Mummery, C. Vasculogenesis and angiogenesis: lessons from genetics in mice. Comm. Theoret. Biol. 7: 381-416, 2002.

Clevers, H. Inflating cell numbers by Wnt. Mol. Cell 10: 1260-1261, 2002.

El-Kadi, A.S.M., In Der Rieden, P., Durston, A. and Morgan, R. The small GTPase Rap1 is an immediate downstream target for Hoxb4 transcriptional regulation. Mech. of Dev. 113: 131-139, 2002.

Elamaa, H., Peterson, J., Pihlajaniemi, T. and Destrée, O. Cloning of three variants of type XVIII collagen and their expression patterns during Xenopus laevis development. Mech. of Dev. 114: 109-113, 2002.

Fischer, S.E.J. Activity of Tc1-like transposons in Caenorhabditis elegans and Mus musculus. Thesis, Univ. Utrecht, pp. 1-85, 2002.

Gleason, J.E., Korswagen, H.C. and Eisenmann, D.M. Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes and Dev. 16: 1281-1290, 2002.

Gross, S., Blanchetot, C., Schepens, J., Albet, S., Lammers, R., Den Hertog, J. and Hendriks, W. Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2b with receptor PTPs (RPTPs). J. Biol. Chem. 277: 48139-48145, 2002.

Houston, D.W., Kofron, M., Resnik, E., Langland, R., Destrée, O., Wylie, C. and Heasman, J. Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3.  Development 129: 4015-4025, 2002.

Itaranta, P., Lin, Y., Perasaari, J., Roël, G., Destrée, O. and Vainio, S. Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Genesis, 32: 259-268, 2002.

Izsvák, Z., Khare, D., Behlke, J., Heinemann, U., Plasterk, R.H.A. and Ivics, Z. Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition. J. Biol. Chem. 277: 34581-34588, 2002.

Jansen, G., Weinkove, D. and Plasterk, R.H.A. The G-protein g subunit gpc-1 of the nematode C. elegans is involved in taste adaptation. Embo J. 21: 986-994, 2002.

Korswagen, H.C. Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans: variations on a common signaling theme. BioEssays 24: 801-810, 2002.

Korswagen, H.C., Coudreuse, D.Y.M., Betist, M.C., Van De Water, S., Zivkovic, D. and Clevers, H.C.  The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes and Dev. 16: 1291-1302, 2002.

Lemmen, J.G. Estrogens and their receptors in murine embryogenesis; their possible role in normal and disrupted development. Thesis, Univ. Utrecht, pp. 1-120, 2002.

Lemmen, J.G., Van Den Brink, C.E., Legler, J., Van Der Saag, P.T. and Van Der Burg, B. Detection of oestrogenic activity of steroids present during mammalian gestation using Era and Erb specific in vitro assays. J. Endocrinol. 174: 435-446, 2002.

Moorman, C. and Plasterk, R.H.A. Functional characterization of the adenylyl cyclase gene sgs-1 by analysis of a mutational spectrum in Caenorhabditis elegans. Genetics 161:133-142, 2002.

Mummery, C.L. Humane embryonale stamcellen: toekomstmogelijkheden voor celtransplantatietherapie. Tijdschr. voor Geneeskunde 127: 189-191, 2002.

Mummery, C.L. and Van Der Saag, P.T. Embryonale stamcellen. Cahiers Bio-Wetenschappen en Maatschappij 21: 15-21, 2002. 

Mummery, C.L.M., Ward-Van Oostwaard, D., Van Den Brink, C.E., Bird, S.D., Doevendans, P.A., Opthof, T., Brutel de la Riviere, A., Tertoolen, L., Van Der Heijden, M. and Pera, M. Cardiomyocyte differentiation of mouse and human embryonic stem cells. J. Anat. 200: 233-242, 2002.

Mummery, C.L.M., Ward-Van Oostwaard, D., Van Den Brink, C.E., Bird, S.D., Doevendans, P.A., Lips, D.J., Opthof, T., Brutel de la Riviere, A., Tertoolen, L., Van Der Heyden, M. and Pera, M. Towards human embryonic stem cell derived cardiomyocytes. In: Cardiovascular genomics: new pathophysiological concepts, edited by Doevendans, P.A. and Kaäb, S. Boston etc.: Kluwer Acad. Publ., 2002, p. 231-243. Proc. 2001 Europ. Sci. Found. Workshop, Maastricht, 2001.

Oosterveen, T. Control of 5’Hoxb expression by retinoids. Thesis, Univ. Utrecht, pp. 1-100, 2002.

Plasterk, R.H.A. RNA silencing: the genome’s immune system. Science 296: 1263-1265, 2002.

Plasterk, R.H.A. and Van Luenen, H.G.A.M. The Tc1/mariner family of transposable elements. In: Mobile DNA II, edited by Craig, N.L., Craigie, R., Gellert, M. and Lambowitz, A.M. Washington: ASM Press, 2002, p. 519-532.

Roël, G., Hamilton, F.S., Gent, Y., Bain, A.A., Destrée, O. and Hoppler, S. Lef-1 and Tcf-3 transcription factors mediate tissue-specific Wnt signaling during Xenopus development. Curr. Biol. 12: 1941-1945, 2002.

Roelen, B.A.J., De Graaff, W., Forlani, S. and Deschamps, J. Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse. Mech. of Dev. 119: 81-90, 2002.

Rohn, J.L., Zhang, Y.-H., Aalbers, R.I.J.M., Otto, N., Den Hertog, J., Henriquez, N.V., Van De Velde, C.J.H., Kuppen, P.J.K., Mumberg, D., Donner, P. and Noteborn, M.H.M. A tumor-specific kinase activity regulates the viral death protein Apoptin. J. Biol. Chem. 277: 50820-50827, 2002.

Schreurs, R., Lanser, P., Seinen, W. and Van Der Burg, B. Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay. Arch. Toxicol. 76:257-261, 2002.

Schreurs, R.H.M.M., Quaedackers, M.E., Seinen, W. and Van Der Burg, B. Transcriptional activation of estrogen receptor ERa and ERb by polycyclic musks is cell type dependent. Toxicol. Appl. Pharmacol. 183: 1-9, 2002.

Simmer, F., Tijsterman, M., Parrish, S., Koushika, S.P., Nonet, M.L., Fire, A., Ahringer, J. and Plasterk, R.H.A. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr. Biol. 12:1317-1319, 2002.

Te Welscher, P., Zuniga, A., Kuijper, S., Drenth, T., Goedemans, H.J., Meijlink, F. and Zeller, R. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science 298: 827-830, 2002.

Tijsterman, M., Ketting, R.F., Okihara, K.L., Sijen, T. and Plasterk, R.H.A. RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs. Science 295: 694-697, 2002.

Tijsterman, M., Ketting, R.F. and Plasterk, R.H.A. The genetics of RNA silencing. Ann. Rev. Genet. 36: 489-519, 2002.

Tijsterman, M., Okihara, K.L., Thijssen, K. and Plasterk, R.H.A. PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans. Curr. Biol. 12: 1535-1540, 2002.

Tijsterman, M., Pothof, J. and Plasterk, R.H.A. Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Genetics 161: 651-660, 2002.

Vaes, B.L.T., Dechering, K.J., Feijen, A., Hendriks, J.M.A., Lefèvre, C., Mummery, C.L., Olijve, W., Van Zoelen, E.J.J. and Steegenga, W.T. Comprehensive microarray analysis of BMP2-induced osteoblast differentiation resulting in the identification of novel markers for bone development. J. Bone Min. Res. 17: 2106-2118, 2002.

Van Den Akker, E., Forlani, S., Chawengsaksophak, K., De Graaff, W., Beck, F., Meyer, B.I. and Deschamps, J. Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development 129: 2181-2193, 2002.

Van Der Sar, A.M., Zivkovic, D. and Den Hertog, J. Eye defects in receptor protein-tyrosine phosphatase a knock-down zebrafish. Dev. Dyn. 223: 292-297, 2002.

Van Noort, M., Meeldijk, J., Van Der Zee, R., Destrée, O. and Clevers, H. Wnt signaling controls the phosphorylation status of b-catenin. J. Biol. Chem. 277: 17901-17905, 2002.

Verbeek, F.J. and Boon, P.J. High resolution 3D-reconstruction from serial sections. Microscope instrumentation, software design and its implementations. In: Three-dimensional and multidimensional microscope: Image Acquisition and Processing IX, edited by Conchello, J.-A., Cogswell, C.J. and Wilson, T. Bellingham, Wash.: SPIE, 2002. Symp. San José, Cal., January 2002. SPIE Proceedings Series, 4621: 65-76, 2002.

Verbeek, F.J., Boon, P.J., Sloetjes, H., Van Der Velde, R. and Vos, N. Visualization of complex data sets over Internet: 2D and 3D visualization of the 3D digital atlas of zebrafish development. In: Internet Imaging III, edited by Beretta, G.B. and Schettini, R. Bellingham, Wash.: SPIE, 2002. Symp. San José, Cal., January 2002. SPIE Proceedings Series, 4672: 20-29, 2002.

Vonken, F., Boxma, B., Tjaden, J., Akhmanova, A., Huynen, M., Verbeek, F., Tielens, A.G.M., Haferkamp, I., Neuhaus, H. E., Vogels, G.,  Veenhuis. M., and Hackstein, J.H.P. Multiple origins of hydrogenosomes: functional and phylogenetic evidence from the ADP/ATP carrier of the anaerobic chytrid Neocallimastix sp. Molec. Microbiol. 44: 1441-1454, 2002.

Wang, D., Passier, R., Liu, Z.P., Shin C.H., Wang, Z., Li, S., Sutherland, L.B., Small, E., Krieg, P.A., Olson, E.N. Regulation of cardiac growth and development by SRF and its cofactors. Cold Spring Harb. Symp. Quant. Biol. 67: 97-105, 2002.

Wienholds, E., Schulte-Merker, S., Walderich, B. and Plasterk, R.H.A. Target-selected inactivation of the zebrafish rag1 gene. Science 297:99-102, 2002.

Zeller, R. and Deschamps, J. First come, first served. Nature 420: 138-139, 2002.

Allen, S.P., Bogardi, J.-P., Barlow, A.J., Mir, S.A., Qayyum, S.R., Verbeek, F.J., Anderson, R.H., Francis-West, P.H., Brown, N.A. and Richardson, M.K. Misexpression of noggin leads to septal defects in the outflow tract of the chick heart. Dev. Biol. 235:98-109, 2001.

Beverdam, A. Functions of Alx3, Alx4 and Cart l during craniofacial development in the mouse. Thesis, Univ. Utrecht, pp. 1-128, 2001.

Beverdam, A., Brouwer, A., Reijnen, M. Korving, J. and Meijlink, F. Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development 128:3975-3986, 2001.

Beverdam, A. and Meijlink, F. Expression patterns of group-I aristaless-related genes during craniofacial and limb development. Mech. of Dev. 107: 163-167, 2001.

Bost, F., Caron, L., Vial, E., Montreau, N., Marchetti, I., Dejong, V., Defize, L., Castellazzi, M. and Binetruy, B. The defective transforming phenotype of c-Jun Ala 63/73 is rescued by mutation of the C-terminal phosphorylation site. Oncogene 20: 7425-7429, 2001.

Braat, A.K., Van De Water, S., Korving, J. and Zivkovic, D. A zebrafish vasa morphant abolishes vasa protein but does not affect the establishment of the germline. Genesis 30: 183-185, 2001.

Doevendans, P.A. and Mummery, C. Pluripotent stem cells: biology and applications. Neth. Heart J. 9: 103-107, 2001.

Fischer, S.E.J., Wienholds, E. and Plasterk, R.H.A. Regulated transposition of a fish transposon in the mouse germ line. Proc. Natn. Acad. Scis USA. 98: 6759-6764, 2001.

Green, C.B., Durston, A.J. and Morgan, R. The circadian gene Clock is restricted to the anterior neural plate early in development and is regulated by the neural inducer noggin and the transcription factor Otx2. Mech. of Dev. 101: 105-110, 2001.

Ketting, R.F., Fischer, S.E.J., Bernstein, E., Sijen, T., Hannon, G.J. and Plasterk, R.H.A. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes and Dev. 15:2654-2659, 2001.

Korswagen, H.C. and Plasterk, R.H.A. Heterotrimeric G proteins. In: Encyclopedia of Genetics, edited by Brenner, S. and Miller, J.H. San Diego: Acad. Press, 2001, p. 933-934.

Larsson, J., Goumans, M.-J., Jansson, L., Van Rooijen, M.A., Ward, D., Levéen, P., Xu, X., Ten Dijke, P., Mummery, C.L. and Karlsson, S. Abnormal angiogenesis but intact hematopoietic potential in TGF-b type I receptor-deficient mice. Embo J. 20: 1663-1673, 2001.

Legler, J. Development and application of in vitro and in vivo reporter gene assays for the assessment of (xeno-)estrogenic compounds in the aquatic environment. Thesis, Univ. Wageningen, pp. 1-132, 2001.

Meerts, I.A.T.M., Letcher, R.J., Hoving, S., Marsh, G. Bergman, Å., Lemmen, J.G., Van Der Burg, B. and Brouwer, A. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybrominated bisphenol A compounds. Environm. Health Persp. 109: 399-407, 2001.

Mummery, C.L. Transforming growth factor b and mouse development. Microsc. Res. Techn. 52: 374-386, 2001.

Narraway, J. The Hubrecht Laboratory Embryological Collection. Int. Congr. Vertebr. Morphol., Jena, July 2001; J. Morphology, 248, p.1, 2001.

Perea-Gomez, A., Lawson, K.A., Rhinn, M., Zakin, L., Brûlet, P., Mazan, S. and Ang, S.-L. Otx2 is required for visceral endoderm movement and for the registration of posterior signals in the epiblast of the mouse embryo. Development 128: 753-765, 2001.

Plasterk, R.H.A. Transposable elements. In: Encyclopedia of Genetics, edited by Brenner, S. and Miller, J.H. San Diego: Acad. Press, 2001, p. 2016-2020.

Quaedackers, M.E., Van Den Brink, C.E., Wissink, S., Schreurs, R.H.M.M., Gustafsson, J.-Å., Van Der Saag, P.T. and Van Der Burg, B. 4-Hydroxytamoxifen trans-represses nuclear factor-kB activity in human osteoblastic U2-OS cells through estrogen receptor (ER) a, and not through ER b. Endocrinology 142: 1156-1166, 2001.

Sijen, T., Fleenor, J., Simmer, F., Thijssen, K.L., Parrish, S., Timmons, L., Plasterk, R.H.A. and Fire, A. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 107: 465-476, 2001.

Tebar, M., Destrée, O., De Vree, W.J.A. and Ten Have-Opbroek, A.A.W. Expression of Tcf/Lef and sFrp and localization of b-catenin in the developing mouse lung. Mech. of Dev. 109: 437-440, 2001.

Ten Berge, D., Brouwer, A., Korving, J., Reijnen, M.J., Van Raaij, E.J., Verbeek, F., Gaffield, W. and Meijlink, F. Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development 128: 2929-2938, 2001.

Tertoolen, L.G.J., Blanchetot, C., Jiang, G., Overvoorde, J., Gadella Jr, T.W.J., Hunter, T. and Den Hertog, J. Dimerization of receptor protein-tyrosine phosphatase alpha in living cells. BMC Cell Biology, 2: 8 * Online journal, 2001.

Van De Water, S., Van De Wetering, M., Joore, J., Esseling, J., Bink, R., Clevers, H. and Zivkovic, D. Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant. Development 128:3877-3888, 2001.

Van De Wetering, M., Barker, N., Harkes, I.C., Van Der Heyden, M., Dijk, N.J., Hollestelle, A., Klijn, J.G.M., Clevers, H. and Schutte, M. Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling. Cancer Res. 61: 278-284, 2001.

Van Den Akker, E. Patterning functions of mouse Hox genes. Thesis, Univ. Utrecht, pp. 1-144, 2001.

Van Den Akker, E., Fromental-Ramain, C., De Graaff, W., Le Mouellic, H., Brûlet, P., Chambon, P. and Deschamps, J. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development 128:1911-1921, 2001.

Van Der Heyden, M.A.G., Roeleveld, L., Peterson, J. and Destrée, O.H.J. Connexin43 expression during Xenopus development. Mech. of Dev. 108: 217-220, 2001.

Van Der Heyden, M.A.G., Roeleveld, L., Reneman, S., Peterson, J. and Destrée, O.H.J. Regulated expression of the X. tropicalis connexin43 promoter. Cell Comm. Adh. 8: 293-298, 2001.

Van Der Linden, A.M., Simmer, F., Cuppen, E. and Plasterk, R.H.A. The G-protein b-subunit GPB-2 in Caenorhabditis elegans regulates the Goa-Gqa signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16.Genetics 158: 221-235, 2001.

Van Der Saag, P. (Ed.) Hubrecht Laboratory; Progress Report 2000. Utrecht, NIOB, pp. 1-78, 2001.

Van Der Sar, A. Protein-tyrosine phosphatases in zebrafish development. Thesis, Univ. Utrecht, pp. 1-144, 2001.

Van Der Sar, A., Betist, M., De Fockert, J., Overvoorde, J., Zivkovic, D. and Den Hertog, J. Expression of receptor protein-tyrosine phosphatase alpha, sigma and LAR during development of the zebrafish embryo. Mech. of Dev. 109: 423-426, 2001.

Van Raaij, E.J., Ten Berge, D., Hage, W., Brouwer, A., Meijlink, F., Maintz, J.B.A. and Verbeek, F.J. Automated topographical cell proliferation analysis. Cytometry 45: 13-18, 2001.

Veltmaat, J. Actions of parathyroid hormone related peptide in mouse parietal endoderm formation. Thesis, Univ. Utrecht, pp. 1-144, 2001.

Weterman, M.A.J., Van Groningen, J.J.M., Tertoolen, L. and Geurts Van Kessel, A. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. Proc. Natn. Acad. Scis 98: 13808-13813, 2001.

Wicks, S.R., Yeh, R.T., Gish, W.R., Waterston, R.H. and Plasterk, R.H.A. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nature Genetics 28: 160-164, 2001.

Wissink, S., Van Der Burg, B., Katzenellenbogen, B.S. and Van Der Saag, P.T. Synergistic activation of the serotonin-1A receptor by nuclear factor-kB and estrogen. Mol. Endocrinol. 15: 543-552, 2001.