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Hubrecht publications

2001   2002   2003   2004   2005


2005
Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B., Hammerschmidt, M. (2005) Destabilization of ?Np63a by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo. Cell Cycle 4: 790-800.

Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., van de Born, M., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S., Clevers, H. (2005) EphB receptor activity suppresses colorectal cancer progression. Nature 435: 1126-1130.

Berezikov, E., Guryev, V., Cuppen, E. (2005) CONREAL web server: identification and visualization of conserved transcription factor binding sites. Nucleic Acids Res. 33: W447-W450.
Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R.H.A., Cuppen, E. (2005) Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120: 21-24.

Berezikov, E., Plasterk, R.H.A. (2005) Camels and zebrafish, viruses and cancer: a microRNA update. Hum. Mol. Genet. 14: R183-R190.

Berghmans, S., Murphey, R.D., Wienholds, E., Neuberg, D., Kutok, J.L., Fletcher, C.D.M., Morris, J.P., Liu, T.X., Schulte-Merker, S., Kanki, J.P., Plasterk, R., Zon, L.I., Look, A.T. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc. Natl. Acad. Sci. 102: 407-412.

Blonden, L., van ‘t Padje, S., Severijnen, L.-A., Destrée, O., Oostra, B.A., Willemsen, R. (2005) Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis. Int. J. Dev. Biol. 49: 437-442.

Bodrikov, V., Leshchyns’ka, I., Sytnyk, V., Overvoorde, J., den Hertog, J., Schachner, M. (2005) RPTPa is essential for NCAM-mediated p59fyn activation and neurite elongation. J. Cell Biol. 168: 127-139.

Bubikat, A., de Windt, L.J., Zetsche, B., Fabritz, L., Sickler, H., Eckardt, D., Gödecke, A., Baba, H.A., Kuhn, M. (2005) Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice. J. Biol. Chem. 280: 21594-21599.

Chuva de Sousa Lopes, S.M., van den Driesche, S., Carvalho, R.L.C., Larsson, J., Eggen, B., Surani, M.A., Mummery, C.L. (2005) Altered primordial germ cell migration in the absence of transforming growth factor ? signaling via ALK5. Dev. Biol. 284: 194-203.

Clevers, H. (2005) Stem cells, asymmetric division and cancer. Nat. Genet. 37: 1027-1028.

Coudreuse, D. (2005) Wnts and worms: from nematodes to vertebrates. Thesis, Univ. Utrecht, pp. 1-144.

Creyghton, M.P., Roël, G., Eichhorn, P.J.A., Hijmans, E.M., Maurer, I., Destrée, O., Bernards, R. (2005) PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 19: 376-386.

Cuppen, E. (2005) Haplotype-based genetics in mice and rats. Trends Genet. 21: 318-322.

de Boer, T.P., Kok, B., Neuteboom, K.I.E., Spieker, N., de Graaf, J., Destrée, O.H.J., Rook, M.B., van Veen, T.A.B., Jongsma, H.J., Vos, M.A., de Bakker, J.M.T., van der Heyden, M.A.G. (2005) Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis. Dev. Dyn. 233: 864-871.

de Guzman, B.B., Hisatsune, J., Nakayama, M., Yahiro, K., Wada, A., Yamasaki, E., Nishi, Y., Yamazaki, S., Azuma, T., Ito, Y., Ohtani, M., van der Wijk, T., den Hertog, J., Moss, J., Hirayama, T. (2005) Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPa and RPTP?, by Helicobacter pylori m2VacA. Cell. Microbiol. 7: 1285-1293.

den Hertog, J. (2005) Chemical genetics: drug screens in zebrafish. Biosci. Rep. 25: 289-297.

den Hertog, J., Groen, A., van der Wijk, T. (2005) Redox regulation of protein-tyrosine phosphatases. Arch. Biochem.Biophys. 434: 11-15.

Denning, C., Passier, R., Mummery, C. (2005) Differentiation of human embryonic stem cells to cardiomyocytes. In: Stem cells: from bench to bedside. Eds. Bongso, A., Lee, E.H., Singapore, World Scientific Press, pp. 301-324.

Deschamps, J., van Nes, J. (2005) Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development 132: 2931-2942.

Donners, M.M.P.C., Bot, I., de Windt, L.J., van Berkel, Th.J.C., Daemen, M.J.A.P., Biessen, E.A.L., Heeneman, S. (2005) Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice. Am. J. Transplant. 5: 1204-1215.

Essers, M.A.G., de Vries-Smits, L.M.M., Barker, N., Polderman, P.E., Burgering, B.M.T., Korswagen, H.C. (2005) Functional interaction between ?-catenin and FOXO in oxidative stress signaling. Science 308: 1181-1184.

Forcet, C., Etienne-Manneville, S., Gaude, H., Fournier, L., Debilly, S., Salmi, M., Baas, A., Olschwang, S., Clevers, H., Billaud, M. (2005) Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum. Mol. Genet. 14: 1283-1292.

Glass II, D.A., Bialek, P., Ahn, J.D., Starbuck, M., Patel, M.S., Clevers, H., Taketo, M.M., Long, F., McMahon, A.P., Lang, R.A., Karsenty, G. (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8: 751-764.

Gregorieff, A., Clevers, H. (2005) Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev. 19: 877-890.

Gregorieff, A., Pinto, D., Begthel, H., Destrée, O., Kielman, M., Clevers, H. (2005) Expression pattern of wnt signaling components in the adult intestine. Gastroenterology 129: 626-638.

Groen, A., Lemeer, S., van der Wijk, Th., Overvoorde, J., Heck, A.J.R., Ostman, A., Barford, D., Slijper, M., den Hertog, J. (2005) Differential oxidation of protein-tyrosine phosphatases. J. Biol. Chem. 280: 10298-10304.

Guryev, V., Berezikov, E., Cuppen, E. (2005) CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences. BMC Genomics 6: 10.

Hsia, D.A., Lim, S.-T., Bernard-Trifilo, J.A., Mitra, S.K., Tanaka, S., den Hertog, J., Streblow, D.N., Ilic, D., Ginsberg, M.H., Schlaepfer, D.D. (2005) Integrin a4?1 promotes focal adhesion kinase-independent cell motility via a4 cytoplasmic domain-specific activation of c-Src. Mol. Cell. Biol. 25: 9700-9712.

Jopling, C., den Hertog, J. (2005) Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO Rep. 6: 426-431.

Kilic, A., Velic, A., de Windt, L.J., Fabritz, L., Voss, M., Mitko, D., Zwiener, M., Baba, H.A., van Eickels, M., Schlatter, E., Kuhn, M. (2005) Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice. Circulation 112: 2307-2317.

Koudijs, M.J., den Broeder, M.J., Keijser, A., Wienholds, E., Houwing, S., van Rooijen, E.M.H.C., Geisler, R., van Eeden, F.J.M. (2005) The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway. PLoS Genet. 1: e19.

Kuijper, S. (2005) Of hearts and bones: function and regulation of aristaless-related genes. Thesis, Univ. Utrecht, pp. 1-104.

Kuijper, S., Beverdam, A., Kroon, C., Brouwer, A., Candille, S., Barsh, G., Meijlink, F. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132: 1601-1610.

Kuijper, S., Feitsma, H., Sheth, R., Korving, J., Reijnen, M., Meijlink, F. (2005) Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh. Dev. Biol. 285: 533-544.

Laoukili, J., Kooistra, M.R.H., Brás, A., Kauw, J., Kerkhoven, R.M., Morrison, A., Clevers, H., Medema, R.H. (2005) FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat. Cell Biol. 7: 126-136.

Liu, F., van den Broek, O., Destree, O., Hoppler, S. (2005) Distinct role for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/?-catenin signalling in mesoderm development. Development 132: 5375-5385.

May, R.C., Plasterk R.H.A. (2005) RNA interference spreading in C. elegans. In: Methods in Enzymology vol. 392, RNA interference. Eds. Abelson, J.N., Simon, M.I., San Diego, Elsevier Academic Press, pp. 308-315.

McNulty, C.L., Peres, J.N., Bardine, N., van den Akker, W.M.R., Durston, A.J. (2005) Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects. Development 132: 2861-2871.

Monteiro, R. (2005) Canonical BMP signalling in vertebrates: lessons from mice and fish. Thesis, Univ. Utrecht, pp. 1-127.

Moore, J.C., van Laake, L.W., Braam, S.R., Xue, T., Tsang, S.-Y., Ward, D., Passier, R., Tertoolen, L.L., Li, R.A., Mummery, C.L. (2005) Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies. Reprod. Toxicol. 20: 377-391.

Mummery, C.L. (2005) Solace for the broken-hearted? Nature 433: 585-587.

Oh, M., Rybkin, I.I., Copeland, V., Czubryt, M.P., Shelton, J.M., van Rooij, E., Richardson, J.A., Hill, J.A., de Windt, L.J., Bassel-Duby, R., Olson, E.N., Rothermel B.A. (2005) Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol. Cell. Biol. 25: 6629-6638.

Parlakian, A., Charvet, C., Escoubet, B., Mericskay, M., Molkentin, J.D., Gary-Bobo, G., de Windt, L.J., Ludosky, M.-A., Paulin, D., Daegelen, D., Tuil, D., Li., Z. (2005) Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation 112: 2930-2939.

Passier, R., Mummery, C. (2005) Cardiomyocyte differentiation from embryonic and adult stem cells. Curr. Opin. Biotechnol. 16: 498-502.

Passier, R., Ward-van Oostwaard, D., Snapper, J., Kloots, J., Hassink, R.J., Kuijk, E., Roelen, B., Brutel de la Rivière, A., Mummery, C. (2005) Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells 23: 772-780.

Pellis-van Berkel, W., Verheijen, M.H., Cuppen, E., Asahina, M., de Rooij, J., Jansen, G., Plasterk, R.H., Bos, J.L., Zwartkruis, F.J. (2005) Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Mol. Biol. Cell 16: 106-116.

Peres, J. (2005) Divide and conquer: segmentation and patterning of the anteroposterior axis. Thesis, Univ. Utrecht, pp. 1-130.

Pinto, D., Clevers, H. (2005) Wnt control of stem cells and differentiation in the intestinal epithelium. Exp. Cell Res. 306: 357-363.

Pinto, D., Clevers, H. (2005) Wnt, stem cells and cancer in the intestine. Biol. Cell 97: 185-196.

Pothof, J. (2005) DNA damage responses in Caenorhabditis elegans. Thesis, Univ. Utrecht, pp. 1-122.

Radtke, F., Clevers, H. (2005) Self-renewal and cancer of the gut: two sides of a coin. Science 307: 1904-1909.

Reya, T., Clevers, H. (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.

Riedl, J.A., Brandt, D.T., Batlle, E., Price, L.S., Clevers, H., Bos, J.L. (2005) Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. Biochem. J. 389: 465-469.

Robert, V.J.P., Sijen, T., van Wolfswinkel, J., Plasterk, R.H.A. (2005) Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev. 19: 782-787.

Sansom, O.J., Reed, K.R., van de Wetering, M., Muncan, V., Winton, D.J., Clevers, H., Clarke, A.R. (2005) Cyclin D1 is not an immediate target of ?-catenin following Apc loss in the intestine. J. Biol. Chem. 280: 28463-28467.


Schreurs, R.H.M.M., Sonneveld, E., van der Saag, P.T., van der Burg, B., Seinen, W. (2005) Examination of the in vitro (anti)estrogenic, (anti)androgenic and (anti)dioxin-like activities of tetralin, indane and isochroman derivatives using receptor-specific bioassays. Toxicol. Lett. 156: 261-275.

Smits, B.M.G. (2005) Natural and induced genetic variation in the rat. Thesis, Univ. Utrecht, pp. 1-128.

Smits, B.M.G., Guryev, V., Zeegers, D., Wedekind, D., Hedrich, H.J., Cuppen, E. (2005) Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. BMC Genomics 6: 170-179.

Smits, B.M.G., Peters, T.A., Mul, J.D., Croes, H.J., Fransen, J.A.M., Beynon, A.J., Guryev, V., Plasterk, R.H.A., Cuppen, E. (2005) Identification of a rat model for Usher syndrome type 1B by N-Ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics 170: 1887-1896.

Staal, F.J.T., Clevers, H.C. (2005) WNT signalling and haematopoiesis: a WNT-WNT situation. Nat. Rev. Immunol. 5: 21-31.

Tops, B.B.J., Tabara, H., Sijen, T., Simmer, F., Mello, C.C., Plasterk, R.H.A., Ketting, R.F. (2005) RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Nucleic Acids Res. 33: 347-355.

Vaes, B.L.T., Dechering, K.J., van Someren, E.P., Hendriks, J.M.A., van de Ven, C.J.J.M., Feijen, A., Mummery, C.L., Reinders, M.J.T., Olijve, W., van Zoelen, E.J.J., Steegenga, W.T. (2005) Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone 36: 803-811.

Valdimarsdottir, G., Mummery, C. (2005) Functions of the TGFß superfamily in human embryonic stem cells. APMIS 113: 773-789.

van den Driesche, S. (2005) Molecular and cellular mechanisms underlying hereditary hemorrhagic telangiectasia. Thesis, Univ. Utrecht, pp. 1-142.

van de Stolpe, A., van den Brink, S., van Rooijen, M., Ward-van Oostwaard, D., van Inzen, W., Slaper-Cortenbach, I., Fauser, B., van den Hout, N., Weima, S., Passier, R., Smith, N., Denning, C., Mummery, C. (2005) Human embryonic stem cells: towards therapies for cardiac disease. RBM Online 11: 476-485.

van der Wijk, T., Blanchetot, C., den Hertog, J. (2005) Regulation of receptor protein-tyrosine phosphatase dimerization. Methods 35: 73-79.

van der Woude, H., ter Veld, M.G.R., Jacobs, N., van der Saag, P.T., Murk, A.J., Rietjens, I.M.C.M. (2005) The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol. Nutr. Food Res. 49: 763-771.

van Empel, V.P.M., Bertrand, A.T.A., Hofstra, L., Crijns, H.J., Doevendans, P.A., de Windt, L.J. (2005) Myocyte apoptosis in heart failure. Cardiovasc. Res. 67: 21-29.

van Empel, V.P.M., Bertrand, A.T., van der Nagel, R., Kostin, S., Doevendans, P.A., Crijns, H.J., de Wit, E., Sluiter, W., Ackerman, S.L., de Windt, L.J. (2005) Downregulation of apoptosis-inducing factor in Harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ. Res. 96: e92-e101.

van Es, J.H., Clevers, H. (2005) Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol. Med. 11: 496-502.

van Es, J.H., Jay, P., Gregorieff, A., van Gijn, M.E., Jonkheer, S., Hatzis, P., Thiele, A., van den Born, M., Begthel, H., Brabletz, T., Taketo, M.M., Clevers, H. (2005) Wnt signaling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 7: 381-386.

van Es, J.H., van Gijn, M.E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D.J., Radtke, F., Clevers, H. (2005) Notch/?-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435: 959-963.

van Laake, L.W., van Hoof, D., Mummery, C.L. (2005) Cardiomyocytes derived from stem cells. Ann. Med. 37: 499-512.

van Oort, R.J., de Windt, L.J. (2005) TOLL-erating cardiac hypertrophy following pressure overload. Cardiovasc. Res. 68: 178-179.

Wehrens, X.H.T., Lehnart, S.E., Reiken, S., van der Nagel, R., Morales, R., Sun, J., Cheng, Z., Deng, S.-X., de Windt, L.J., Landry, D.W., Marks, A.R. (2005) Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc. Natl. Acad. Sci. 102: 9607-9612.

Wienholds, E. (2005) Reverse genetics and microRNAs in zebrafish. Thesis, Univ. Utrecht, pp. 1-124.

Wienholds, E., Kloosterman, W.P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, H.R., Kauppinen, S., Plasterk, R.H.A. (2005) MicroRNA expression in zebrafish embryonic development. Science 309: 310-311.

Wienholds, E., Plasterk, R.H.A. (2005) MicroRNA function in animal development. FEBS Lett. 579: 5911-5922.

Wilson, M.E., Yang, K.Y., Kalousova, A., Lau, J., Kosaka, Y., Lynn, F.C., Wang, J., Mrejen, C., Episkopou, V., Clevers, H.C., German, M.S. (2005) The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes 54: 3402-3409.

2004
Agronskaia, A.V., Tertoolen, L., Gerritsen, H.C. (2004) Fast fluorescence lifetime imaging of calcium in living cells. J. Biomed. Opt. 9:1230-1237.

Armand, A.-S., de Windt, L.J. (2004) Calcium cycling in heart failure: how the fast became too furious. Cardiovasc. Res. 62: 439-441.

Baas, A.F. (2004) LKB1 a master regulator of cell polarity. Thesis, Univ. Utrecht, pp. 1-80.

Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J., Clevers, H.C. (2004) Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116: 457-466.

Baas, A.F., Smit, L., Clevers, H. (2004) LKB1 tumor suppresor protein: PARtaker in cell polarity. Trends Cell Biol. 14: 312-319.

Babiker, F.A., de Windt, L.J., van Eickels, M., Thijssen, V., Bronsaer, R.J.P., Grohé, C., van Bilsen, M., Doevendans, P.A. (2004) 17ß-estradiol antagonizes cardiomyocyte hypertrophy by autocrine/paracrine stimulation of a guanylyl cyclase A receptor-cyclic guanosine monophosphate-dependent protein kinase pathway. Circulation 109: 269-276.

Bakkers, J. Kramer, C., Pothof, J., Quaedvlieg, N.E.M., Spaink, H.P., Hammerschmidt, M. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131: 527-537.

Berezikov, E., Bargmann, C., Plasterk, R.H.A. (2004) Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res. 32: e40.

Berezikov, E., Guryev, V., Plasterk R.H.A., Cuppen, E. (2004) CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res. 14: 170-178.

Blache, P., van de Wetering, M., Duluc, I., Doman, C., Berta, P., Freund, J.N., Clevers, H., Jay, P. (2004) SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J. Cell Biol. 166: 37-47.

Blacque, O.E., Reardon, M.J., Li, C., McCarthy, J., Mahjoub, M.R., Ansley, S.J., Badano, J.L., Mah, A.K., Beales, P.L., Davidson, W.S., Johnsen, R.C., Audeh, M., Plasterk, R.H.A., Baillie, D.L., Katsanis, N., Quarmby, L.M., Wicks, S.R., Leroux, M.R. (2004) Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 18: 1630-1642.

Boersma-Vreugdenhil, G.R., Kuipers, J., van Stralen, E., Peeters, T., Michaux, L., Hagemeijer, A., Pearson, P.L., Clevers, H.C., Bast, B.J.E.G. (2004) The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint. Br. J. Haemotol. 126: 355-363.

Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M., Birchmeier, W. (2004) Essential role of BCL9-2 in the switch between ß-catenin's adhesive and transcriptional functions. Genes Dev. 18: 2225-2230.

Candille, S.I., van Raamsdonk, C.D., Chen, C., Kuijper, S., Chen-Tsai, Y., Russ, A., Meijlink, F., Barsh, G.S. (2004) Dorsoventral patterning of the mouse coat by Tbx15. PLoS Biol. 2: 30-42.

Carvalho, R. (2004) TGFß signaling, endoglin and vascular development in mice. Thesis, Univ. Utrecht, pp 1-128.

Carvalho, R., Jonker, L., Goumans, M.J., Larsson, J., Bouwman, P., Karlsson, S., ten Dijke, P., Arthur, H., Mummery, C. (2004) Defective paracrine signaling by TGFß in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary hemorrhagic telangiectasia. Development 131: 6237-6247.

Chawengsaksophak, K., de Graaff, W., Rossant, J., Deschamps, J., Beck, F. (2004) Cdx2 is essential for axial elongation in mouse development. Proc. Natl. Acad. Sci. 101: 7641-7645.

Chuva de Sousa Lopes, S.M. (2004) BMPs, TGFßs and integrins in muscle and germ cell development in mice. Thesis, Univ. Utrecht, pp 1-105.

Chuva de Sousa Lopes, S.M., Feijen, A., Korving, J., Korchynskyi, O., Larsson, J., Karlsson, S., ten Dijke, P., Lyons, K.M., Goldschmeding, R., Doevendans, P., Mummery, C.L. (2004) Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev. Dyn. 231: 542-550.

Chuva de Sousa Lopes, S.M., Mummery, C.L. (2004) Differentiation in early development. In: Handbook of Stem Cells, volume 1, Embryonic Stem Cells. Ed. Lanza, R., San Diego, Elsevier Academic Press, pp. 143-156.

Chuva de Sousa Lopes, S.M., Roelen, B.A.J., Monteiro, R.M., Emmens, R., Lin, H.Y., Li, E., Lawson, K.A., Mummery, C.L. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 18: 1838-1849.

Clevers, H. (2004) At the crossroads of inflammation and cancer. Cell 118: 671-674.

Clevers, H. (2004) Signaling mucins in the (s)limelight. Dev. Cell 7: 150-151.

Clevers, H. (2004) Wnt signaling: Ig-Norrin the dogma. Curr. Biol. 14: R436-R437.

de Jong, D.S., Vaes, B.L.T., Dechering, K.J., Feijen, A., Hendriks, J.M.A., Wehrens, R., Mummery, C.L., van Zoelen, E.J.J., Olijve, W., Steenenga, W.T. (2004) Identification of novel regulators associated with early-phase osteoblast differentiation. J. Bone Miner. Res. 19: 947-958.

de Windt, L.J., Doevendans, P.A., Chien, K.R. (2004) Generation and cloning of genetically modified animals. In: The molecular basis of cardiovascular disease, 2nd edition - a companion to Braunwald’s heart disease. Ed. Chien K.R., Philadelphia, PA, USA, W.B. Saunders Co., pp. 49-71.

den Hertog, J. (2004) Receptor protein tyrosine phosphatases. Topics in Current Genetics 5: 253-274.

Denli, A.M., Tops, B.B.J., Plasterk, R.H.A., Ketting, R.F., Hannon, G.J. (2004) Processing of primary microRNAs by the microprocessor complex. Nature 432: 231-235.

Derksen, P.W.B., Tjin, E., Meijer, H.P., Klok, M.D., MacGillavry, H.D., van Oers, M.H.J., Lokhorst, H.M., Bloem, A.C., Clevers, H., Nusse, R., van der Neut, R., Spaargaren, M., Pals, S.T. (2004) Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc. Natl. Acad. Sci.: 101: 6122-6127.

Deschamps, J. (2004) Hox genes in the limb: a plan in two acts. Science 304: 1610-1611.

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Beverdam, A. and Meijlink, F. Expression patterns of group-I aristaless-related genes during craniofacial and limb development. Mech. of Dev. 107: 163-167, 2001.

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Legler, J. Development and application of in vitro and in vivo reporter gene assays for the assessment of (xeno-)estrogenic compounds in the aquatic environment. Thesis, Univ. Wageningen, pp. 1-132, 2001.

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