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Hubrecht publications

1996   1997   1998   1999   2000


2000
Blanchetot, C. Dimerization of receptor protein-tyrosine phosphatases; characterization of RPTPa interacting proteins, Thesis, Univ. Utrecht, 2000. pp. 1-144.

Blanchetot, C. and Den Hertog, J. Antibody-induced dimerization of HARPTPa/EGFR chimera suggests a ligand dependent mechanism of regulation for RPTPa . Febs Lett. 484: 235-240, 2000. 

Blanchetot, C. and Den Hertog, J. Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) a and membrane-distal protein-tyrosine phosphatase domains of various RPTPs. J. Biol. Chem. 275: 12446-12452, 2000.

Boon, P.J., Eminovi?, N., De Vos, A., Buitendijk, B., Van Raaij, E.J., Den Broeder, M.J., Hage, W.J. and Verbeek, F.J. A virtual lab-notebook for multidimensional microscope images. In: Information Visualisation, edited by Banissi, E. et al. Los Alamitos: IEEE Computer Soc., 2000. Proc. 2000 IEEE Conf. on Information Visualisation, London. pp. 187-191, 2000.

Braat, A.K., Van De Water, S., Goos, H., Bogerd, J. and Zivkovic, D. Vasa protein expression and localization in the zebrafish. Mech. of Dev.  95: 271-274, 2000.

Buist, A., Blanchetot, C. and Den Hertog, J. Involvement of the membrane distal catalytic domain in pervanadate-induced tyrosine phosphorylation of receptor protein-tyrosine phosphatase a.  Biochem. Biophys. Res. Comm. 267: 96-102, 2000.

Buist, A., Blanchetot, C., Tertoolen, L.G.J. and Den Hertog, J. Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase a. J. Biol. Chem. 275: 20754-20761, 2000.

Caricasole, A., Ward-Van Oostwaard, D., Mummery, C. and Van Den Eijnden-Van Raaij, A. Bone morphogenetic proteins and retinoic acid induce human endogenous retrovirus HERV-K expression in NT2D1 human embryonal carcinoma cells. Dev. Growth Diff. 42: 407-411, 2000.

Caricasole, A., Ward-Van Oostwaard, D., Zeinstra, L., Van Den Eijnden-Van Raaij, A. and Mummery, C. Bone morphogenetic proteins (BMPs) induce epithelial differentiation of NT2D1 human embryonal carcinoma cells. Int. J. Dev. Biol. 44: 443-450, 2000.

De Groot, E. Genes regulated during ectodermal patterning of the mouse embryo at gastrulation, Thesis, Univ. Utrecht, 2000. pp. 1-118.

De Groot, E., Feijen, A., Eib, D., Zwijsen, A., Sugino, H., Martens, G. and Van Den Eijnden-Van Raaij, A.J.M. Expression patterns of follistatin and two follistatin-related proteins during mouse development. Int. J. Dev. Biol. 44: 327-330, 2000.

De Groot, E., Veltmaat, J.M., Caricasole, A., Defize, L.H.K. and Van Den Eijnden-Van Raaij, A.J.M. Cloning and analysis of the mouse follistatin promoter. Mol. Biol. Rep. 27: 129-139, 2000.

Eib, D.W., Holling, T.M., Zwijsen, A., Dewulf, N., De Groot, E., Van Den Eijnden-Van Raaij, A.J.M., Huylebroeck, D. and Martens, G.J.M. Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. Mech. of Dev. 97: 167-171, 2000.

Eijkelenboom, A.P.A.M., Van Den Ent, F.M.I., Wechselberger, R., Plasterk, R.H.A., Kaptein, R. and Boelens, R. Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase. J. Biomol.NMR 18:119-128, 2000.

García-Sáez, I. and Plasterk, R.H.A. Purification of the Caenorhabditis elegans transposase Tc1A refolded during gel filtration chromatography. Protein Expres. Purif. 19: 355-361, 2000.

Goumans, M.-J. and Mummery, C. Functional analysis of the TGFb receptor/Smad pathway through gene ablation in mice. Int. J. Dev. Biol. 44: 253-265, 2000.

Holling, T.M., Van Herp, F. Durston, A.J. and Martens, G.J.M. Differential onset of expression of mRNAs encoding proopiomelanocortin, prohormone convertases 1 and 2, and granin family members during Xenopus laevis development. Mol. Brain Res. 75: 70-75, 2000.

Izsvák, Z., Ivics, Z. and Plasterk, R.H.A. Sleeping beauty, a wide host-range transposon vector for genetic transformation in vertebrates. J. Mol. Biol. 302:93-102, 2000.

Jansen, G., Thijssen, K.L., Werner, P., Van Der Horst, M., Hazendonk, E. and Plasterk, R.H.A. The heterotrimeric G protein genes of Caenorhabditis elegans. In: Ernst Schering Research Foundation Workshop 29, edited by Stock, G. Berlin: Springer, 2000, p. 13-34.

Jiang, G., Den Hertog, J. and Hunter, T. Receptor-like protein tyrosine phosphatase a homodimerizes on the cell surface. Mol. Cell. Biol. 20: 5917-5929, 2000.

Kester, H.A., Ward-Van Oostwaard, T.M.J., Goumans, M.-J., Van Rooijen, M.A., Van Der Saag, P.T., Van Der Burg, B. and Mummery, C.L. Expression of TGF-b stimulated clone-22 (TSC-22) in mouse development and TGF-b signalling. Dev. Dyn. 218: 563-572, 2000.

Ketting, R.F. Regulation of transposon activity in the germline of Caenorhabditis elegans, Thesis, Univ. Utrecht, 2000. pp. 1-106.

Ketting, R.F. and Plasterk, R.H.A. A genetic link between co-suppression and RNA interference in C. elegans. Nature 404:296-298, 2000.

Koch, R., Van Luenen, H.G.A.M., Van Der Horst, M. , Thijssen, K.L. and Plasterk, R.H.A. Single nucleotide polymorphisms in wild isolates of Caenorhabditis  elegans. Genome Res. 10: 1690-1696, 2000.

Korswagen, H.C. and Clevers, H.C. Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. Cold Spring Harb. Symp. Quant. Biol. 64:141-147, 2000.

Korswagen, H.C., Herman, M.A. and Clevers, H.C. Distinct b-catenins mediate adhesion and signalling functions in C. elegans. Nature 406:527-532, 2000.

Legler, J., Broekhof, J.L.M., Brouwer, A., Lanser, P.H., Murk, A.J., Van Der Saag, P.T., Vethaak, A.D., Wester, P., Zivkovic, D. and Van Der Burg, B. A novel in vivo bioassay for (xeno-)estrogens using transgenic zebrafish. Environm. Sci. Toxicol. 34: 4439-4444, 2000.  

Molenaar, M. A dual action of XTcf-3 in body axis formation, Thesis, Univ. Utrecht, 2000. pp. 1-104.

Molenaar, M., Brian, E., Roose, J., Clevers, H. and Destrée. O. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mech. of Dev. 91: 311-315, 2000.

Morgan, R., In Der Rieden, P., Hooiveld, M.H.W. and Durston, A.J. Identifying Hox paralog groups by the PBX-binding region. Trends in  Genet. 16: 66-67, 2000.

Motley, A.M., Hettema, E.H., Ketting, R., Plasterk, R.H.A. and Tabak, H.F. Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes. Embo Rep. 1: 40-46, 2000.

Nielsen, M., Høyer, P.E., Lemmen, J.G., Van Der Burg, B. and Byskov, A.G. Octylphenol does not mimic diethylstilbestrol-induced oestrogen receptor-a expression in the newborn mouse uterine epithelium after prenatal exposure. J. Endocrinol. 167: 29-37, 2000.

Odenthal, J., Van Eeden, F.J., Haffter, P., Ingham, P.W., Nüsslein-Volhard, C. Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219:350-363, 2000.

Pilon, M., Peng, X.-R., Spence, A.M., Plasterk, R.H.A. and Dosch, H.-M. The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Mol. Biol. Cell 11: 3277-3288, 2000.

Plasterk, R.H.A. and Ketting, R.F. The silence of the genes. Curr. Op. Genet. Dev. 10:562-567, 2000.

Roelen, B.A.J. and Mummery, C.L. Transforming growth factor-bs in pre-gastrulation development of mammals. Mol. Reprod.Dev. 56: 220-226, 2000.

Schubert, C.M., Lin, R., De Vries, C.J., Plasterk, R.H.A. and Priess, J.R. Mex-5 and mex-6 function to establish soma/germline asymmetry in early C. elegans embryos. Mol. Cell 5: 671-682, 2000.

Van Der Heyden, M.A.G., Veltmaat, J.M., Hendriks, J.A.A., Destrée, O.H.J. and Defize, L.H.K. Dynamic connexin43 expression and gap junctional communication during endoderm differentiation of F9 embryonal carcinoma cells. Europ. J. Cell Biol. 79: 272-282, 2000.

Van Der Velden, A.W., Destrée, O.H.J., Voorma, H.O. and Thomas, A.A.M. Controlled translation initiation on insulin-like growth factor 2-leader 1 during Xenopus laevis embryogenesis. Int. J. Dev. Biol. 44: 843-850, 2000.

Veltmaat, J.M., Orelio, C.C., Ward-Van Oostwaard, D., Van Rooijen, M.A., Mummery, C.L. and Defize, L.H.K. Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation. Int. J. Dev. Biol. 44: 297-307, 2000.

Verbeek, F.J. Three-dimensional (3D) reconstruction from serial sections. In: Image Processing and Analysis, edited by Baldock, R. and Graham, J. Oxford: Univ. Press, 2000. The Practical Approach Series. pp. 153-195, 2000.

Verbeek, F.J., Den Broeder, M.J., Boon, P.J., Buitendijk, B., Doerry, E., Van Raaij, E.J. and Zivkovic, D. A standard 3D digital atlas of zebrafish embryonic development for projection of experimental data. In: Proceedings IS and T/SPIE Conf. on Internet Imaging. San Jose, Cal., 2000. SPIE Proceedings Series 3964: 242-252, 2000.

Wicks, S.R., De Vries, C.J., Van Luenen, H.G.A.M. and Plasterk, R.H.A. CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans. Dev. Biol. 221: 295-307, 2000.

Wissink, S., Meijer, O., Pearce, D., Van Der Burg, B. and Van Der Saag, P.T. Regulation of the rat serotonin-1A receptor gene by corticosteroids. J. Biol. Chem. 275: 1321-1326, 2000.

Ying, Y., Liu, X., Marble, A., Lawson, K.A. and  Zhao, G.Q. Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Mol. Endocrinol. 14: 1053-1063, 2000.

Zomer, A.W.M., Jansen, G.A., Van Der Burg, B., Verhoeven, N.M., Jakobs, C., Van Der Saag, P.T., Wanders, R.J.A. and Poll-The, B.T. Phytanoyl-CoA hydroxylase activity is induced by phytamic acid. Europ. J. Biochem. 267: 4063-4067, 2000.

Zomer, A.W.M., Van Der Burg, B., Jansen, G.A., Wanders, R.J.A., Poll-The, B.T. and Van Der Saag, P.T. Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor a.  J. Lipid Res. 41: 1801-1807, 2000.

Zwijsen, A., Van Rooijen, M.A., Goumans, M.-J., Dewulf, N., Bosman, E.A., Ten Dijke, P., Mummery, C.L. and Huylebroeck, D. Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis. Dev. Dyn. 218: 663-670, 2000.

1999

Braat, A.K. Characterization of germ line development in zebrafish; molecular and functional aspects, Thesis, Univ. Utrecht, 1999. pp. 1-122.

Braat, A.K., Speksnijder, J.E., and Zivkovic, D. Germ line development in fishes. Int.J.Dev.Biol. 43:745-760, 1999.

Braat, A.K., Zandbergen, M.A., De Vries, E., Van Der Burg, B., Bogerd, J. and Goos, H.J.T. Cloning and expression of the zebrafish germ cell nuclear factor. Mol.Reprod.Dev. 53:369-375, 1999.

Braat, A.K., Zandbergen, T., Van De Water, S., Goos, H.J.T. and Zivkovic, D. Characterization of zebrafish primordial germ cells: morphology and early distribution of vasa RNA. Dev. Dyn. 216:153-167, 1999.

Buist, A. Characterization of receptor protein-tyrosine phosphatase a, Thesis, Univ. Utrecht, 1999. pp. 1-152.

Buist, A., Zhang, Y.-L., Keng, Y.-F., Wu, L., Zhang, Z.-Y. and Den Hertog, J. Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase a. Biochemistry 38:914-922, 1999.

De Laat, S.W., Boonstra, J., Defize, L.H.K., Kruijer, W., Van Der Saag, P.T., Tertoolen, L.G.J., Van Zoelen, E.J.J. and Den Hertog, J. Growth factor signalling. Int.J.Dev.Biol. 43:681-691, 1999.

De Roos, K., Sonneveld, E., Compaan, B., Ten Berge, D., Durston, A.J. and Van Der Saag, P.T. Expression of retinoic acid 4-hydroxylase (CYP26) during mouse and Xenopus laevis embryogenesis. Mech.of Dev. 82:205-211, 1999.

Den Hertog, J. Protein-tyrosine phosphatases in development. Mech.of Dev. 85:3-14, 1999.

Den Hertog, J., Blanchetot, C., Buist, A., Overvoorde, J., Van Der Sar, A. and Tertoolen, L.G.J. Receptor protein-tyrosine phosphatase signalling in development. Int.J.Dev.Biol. 43:723-733, 1999.

Deschamps, J., Van Den Akker, E., Forlani, S., De Graaff, W., Oosterveen, T., Roelen, B. and Roelfsema, J. Initiation, establishment and maintenance of Hox gene expression patterns in the mouse. Int.J.Dev.Biol. 43:635-650, 1999.

Durston, A.J. Discovery of a morphogen. Int.J.Dev.Biol. 43:625-627, 1999.

Durston, A.J.(Ed) The Hubrecht Laboratory: The Netherlands Institute for Developmental Biology; Special Issue. Int.J.Dev.Biol. 43,no.7, pp.579-776, 1999.

Faasse, P., Faber, J. and Narraway, J. A brief history of the Hubrecht Laboratory. Int.J.Dev.Biol. 43:583-590, 1999.

Goumans, M.-J. Functional analysis of TGFb signalling in early mouse development, Thesis, Univ.Utrecht, 1999. pp. 1-152.

Goumans, M.-J., Zwijsen, A., Van Rooijen, M.A., Huylebroeck, D., Roelen, B.A.J. and Mummery, C.L. Transforming growth factor-b signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice. Development 126:3473-3483, 1999.

Gu, Z., Reynolds, E.M., Song, J., Lei, H., Feijen, A., Yu, L., He, W., MacLaughlin, D.T., Van Den Eijnden-Van Raaij, J., Donahoe, P.K. and Li, E. The type I serine/threonine kinase receptor ActRlA (ALK2) is required for gastrulation of the mouse embryo. Development 126:2551-2561, 1999.

Hooiveld, M.H.W. Establishment of the neuraxis in Xenopus laevis, Thesis, Univ. Utrecht, 1999. pp. 1-116.

Hooiveld, M.H.W., Morgan, R., In Der Rieden, P., Houtzager, E., Pannese, M., Damen, K., Boncinelli, E. and Durston, A.J. Novel interactions between vertebrate Hox genes. Int.J.Dev.Biol. 43:665-674, 1999.

Jiang, G., Den Hertog, J., Su, J., Noel, J., Sap, J. and Hunter, T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-a. Nature 401:606-610, 1999.

Jonkers, J., Van Amerongen, R., Van Der Valk, M., Robanus-Maandag, E., Molenaar, M., Destrée, O.H.J. and Berns, A. In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3. Mech.of Dev. 88:183-194, 1999.

Joore, J. Promoter analysis in zebrafish embryos. In: Molecular Methods in Developmental Biology: Xenopus and Zebrafish, edited by Guille, M. Totowa, N.J.: Humana Press, 1999. Methods in Molecular Biology 127: 155-166, 1999.

Karperien, M., Farih-Sips, H., Hendriks, J.A.A., Lanske, B., Papapoulos, S.E., Abdul-Badi Abou-Samra, , Löwik, C.W.G.M. and Defize, L.H.K. Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene. Mol.Endocrinol. 13:1183-1196, 1999.

Kester, H.A. Progestin action in human breast- and endometrial tumor cells: role of progesterone target gene TSC-22, Thesis, Univ. Utrecht, 1999. pp. 1-108.

Kester, H.A., Blanchetot, C., Den Hertog, J., Van Der Saag, P.T. and Van Der Burg, B. Transforming growth factor-b-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. J.Biol.Chem. 274:27439-27447, 1999.

Lawson, K.A. Fate mapping the mouse embryo. Int.J.Dev.Biol. 43:773-775, 1999.

Lawson, K.A., Dunn, N.R., Roelen, B.A.J., Zeinstra, L.M., Davis, A.M., Wright, C.V.E., Korving, J.P.W.F.M. and Hogan, B.L.M. Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes and Dev. 13:424-436, 1999.

Legler, J., Van Den Brink, C.E., Brouwer, A., Murk, A.J., Van Der Saag, P.T., Vethaak, A.D. and Van Der Burg, B. Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol.Scis 48:55-66, 1999.

Lemmen, J.G., Broekhof, J.L.M., Kuiper, G.G.J.M., Gustafsson, J.-Å., Van Der Saag, P.T. and Van Der Burg, B. Expression of estrogen receptor alpha and beta during mouse embryogenesis. Mech.of Dev. 81:163-167, 1999.

Meijlink, F., Beverdam, A., Brouwer, A., Oosterveen, T.C. and Ten Berge, D. Vertebrate aristaless-related genes. Int.J.Dev.Biol. 43:651-663, 1999.

Molenaar, M. and Destrée, O.H.J. A tight control over Wnt action. Int.J.Dev.Biol. 43:675-680, 1999.

Morgan, R., Hooiveld, M.H.W. and Durston, A.J. A novel guanine exchange factor increases the competence of early ectoderm to respond to neural induction. Mech.of Dev. 88:67-72, 1999.

Morgan, R., Hooiveld, M.H.W., In Der Rieden, P. and Durston, A.J. A conserved 30 base pair element in the Wnt-5a promoter is sufficient both to drive its' early embryonic expression and to mediate its' repression by otx2. Mech.of Dev. 85:97-102, 1999.

Morgan, R., Hooiveld, M.H.W., Pannese, M., Dati, G., Broders, F., Delarue, M., Thiery, J.-P., Boncinelli, E. and Durston, A.J. Calponin modulates the exclusion of otx-expressing cells from convergent extension movements. Nature Cell Biol. 1:404-408, 1999.

Mummery, C.L. and Van Den Eijnden-Van Raaij, A.J.M. Developmental tumours, early differentiation and the transforming growth factor b superfamily. Int.J.Dev.Biol. 43:693-709, 1999.

Nieuwkoop, P.D. (ed. by Gordon, R. and Björklund, N.K.) The neural induction process; its morphogenetic aspects. Int.J.Dev.Biol. 43:615-623, 1999.

Pap, E.H.W., Drummen, G.P.C., Winter, V.J., Kooij, T.W.A., Rijken, P., Wirtz, K.W.A., Op Den Kamp, J.A.F., Hage, W.J. and Post, J.A. Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY581/591. FEBS letters 453:278-282, 1999.

Richardson, M.K. and Narraway, J. A treasure house of comparative embryology. Int.J.Dev.Biol. 43:591-602, 1999.

Roshani, H., Dabhoiwala, N.F., Verbeek, F.J., Kurth, K.H. and Lamers, W.H. Anatomy of ureterovesical junction and distal ureter studied by endoluminal ultrasonography in vitro. J.Urol. 161:1614-1619, 1999.

Sonneveld, E. Retinoic acid metabolism: cause or consequence of RA action? A dual role for cytochrome P450 retinoic acid hydroxylase CYP26, Thesis, Univ. Utrecht, 1999. pp. 1-134.

Sonneveld, E., Van Den Brink, C.E., Tertoolen, L.G.J., Van Der Burg, B. and Van Der Saag, P.T. Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells. Dev.Biol. 213:390-404, 1999. 

Sonneveld, E., Van Den Brink, C.E., Van Der Leede, B.-J.M., Maden, M. and Van Der Saag, P.T. Embryonal carcinoma cell lines stably transfected with mRARb2-LACZ: sensitive system for measuring levels of active retinoids. Exp.Cell Res. 250:284-297, 1999.

Teicher, V.B., Kucharski, N., Martin, H.-D., Van Der Saag, P.T., Sies, H. and Stahl, W. Biological activities of Apo-canthaxanthinoic acids related to gap junctional communication. Arch.Biochem.Biophys. 365:150-155, 1999.

Ten Berge, D. Genetic regulation of skeletal development in the mouse; role of aristaless-related homeobox genes, Thesis, Univ. Utrecht, 1999. pp. 1-104.

Thorsteinsdöttir, S., Roelen, B.A.J., Goumans, M.-J., Ward-Van Oostwaard, D., Gaspar, A.C. and Mummery, C.L. Expression of the a6A integrin splice variant in developing mouse embryonic stem cell aggregates and correlation with cardiac muscle differentiation. Differentiation 64:173-184, 1999.

Van Den Akker, E., Reijnen, M., Korving, J., Brouwer, A., Meijlink, F. and Deschamps, J. Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. Mech.of Dev. 89:103-114, 1999.

Van Den Brink, G.R., Bloemers, S.M., Van Den Blink, B., Tertoolen, L.G.J., Van Deventer, S.J.H. and Peppelenbosch, M.P. Study of calcium signaling in non-excitable cells. Microsc.Res.Techn. 46:418-433, 1999.

Van Der Burg, B., Sonneveld, E., Lemmen, J.G. and Van Der Saag, P.T. Morphogenetic action of retinoids and estrogens. Int.J.Dev.Biol. 43:735-743, 1999.

Van Der Sar, A.M., De Fockert, J., Betist, M., Zivkovic, D. and Den Hertog, J. Pleiotropic effects of zebrafish protein-tyrosine phosphatase-1B on early embryonic development. Int.J.Dev.Biol. 43:785-794, 1999.

Van Eijk, M.J.T., Van Rooijen, M.A., Modina, S., Scesi, L., Folkers, G., Van Tol, H.T.A., Bevers, M.M., Fisher, S.R., Lewin, H.A., Rakacolli, D., Galli, C., De Vaureix, C., Trounson, A.O., Mummery, C.L. and Gandolfi, F. Molecular cloning, genetic mapping and developmental expression of bovine POU5F1. Biol.Reprod. 60:1093-1103, 1999.

Van Es, J.H., Kirkpatrick, C., Van De Wetering, M., Molenaar, M., Miles, A., Kuipers, J., Destrée, O.H.J., Peifer, M. and Clevers, H. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr.Biol. 9:105-108, 1999.

Van Pelt, A.M.M., De Rooij, D.G., Van Der Burg, B., Van Der Saag, P.T., Gustafsson, J.-Å. and Kuiper, G.G.J.M. Ontogeny of estrogen receptor b expression in rat testis. Endocrinology 140:478-483, 1999.

Van Puijenbroek, A.A.F.L., Van Der Saag, P.T. and Coffer, P.J. Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-Erk signaling. Exp.Cell Res. 251:465-476, 1999.

Van Puijenbroek, A.A.F.L., Wissink, S., Van Der Saag, P.T. and Peppelenbosch, M.P. Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block TNF-induced NF-kB activation. Cytokine 11:104-110, 1999.

Van Raaij, E.J., Boon, P.J., Maintz, J.B.A. and Verbeek, F.J. Composition of high resolution image mosaics for 3D reconstructions from serial sections in microscopy. In: Proceedings of the International Workshop on Biomedical Image Registration, edited by Kovacic, S., Pernus, F., Stiehl, H.S. and Viergever, M.A. 1999. Bled, Slovenia, August 1999. pp. 262-271, 1999.

Van Schothorst, E.M., Mohkamsing, S., Van Gurp, R.J.H.L.M., Oosterhuis, J.W., Van Der Saag, P.T. and Looijenga, L.H.J. Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines. Brit.J.Cancer 80:1571-1574, 1999.

Van Tilborg, P.J.A., Mulder, F.A.A., De Backer, M.M.E., Nair, M., Van Heerde, E.C., Folkers, G., Van Der Saag, P.T., Karimi-Nejad, Y., Boelens, R. and Kaptein, R. Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation. Biochemistry 38:1951-1956, 1999.

Veenstra, G.J.C., Destrée, O.H.J. and Wolffe, A.P. Translation of maternal TATA-binding protein mRNA potentiates basal but not activated transcription in Xenopus embryos at the midblastula transition. Mol.Cell.Biol. 19:7972-7982, 1999.

Veenstra, G.J.C., Mathu, M.T. and Destrée, O.H.J. The Oct-1 POU domain directs developmentally regulated nuclear translocation in Xenopus embryos. Biol.Chem. 380:253-257, 1999.

Verbeek, F.J., Lawson, K.A. and Bard, J.B.L. Developmental bioinformatics: linking genetic data to virtual embryos. Int.J.Dev.Biol. 43:761-771, 1999.

Verheijen, M.H.G. and Defize, L.H.K. Signals governing extraembryonic endoderm formation in the mouse: involvement of the type 1 parathyroid hormone-related peptide (PTHrP) receptor, p21Ras and cell adhesion molecules. Int.J.Dev.Biol. 43:711-721, 1999.

Verheijen, M.H.G., Karperien, M., Chung, U-i., Van Wijnen, M., Heystek, H., Hendriks, J.A.A., Veltmaat, J.M., Lanske, B., Li, E., Löwik, C.W.G.M., De Laat, S.W., Kronenberg, H.M. and Defize, L.H.K. Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the type I PTH/PTHrP receptor. Mech.of Dev. 81:151-161, 1999.

Verheijen, M.H.G., Wolthuis, R.M.F., Bos, J.L. and Defize, L.H.K. The Ras/Erk pathway induces primitive endoderm but prevents parietal endoderm differentiation of F9 embryonal carcinoma cells. J.Biol.Chem. 274:1487-1494, 1999.

Verheijen, M.H.G., Wolthuis, R.M.F., Defize, L.H.K., Den Hertog, J. and Bos, J.L. Interdependent action of Ra1GEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells. Oncogene 18:4435-4439, 1999.

Wuytens, G., Verschueren, K., De Winter, J.P., Gajendran, N., Beek, L., Devos, K., Bosman, F., De Waele, P., Andries, M., Van Den Eijnden-Van Raaij, A.J.M., Smith, J.C. and Huylebroeck, D. Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors. J.Biol.Chem. 274:9821-9827, 1999.

Zwijsen, A., Goumans, M.-J., Lawson, K.A., Van Rooijen, M.A. and Mummery, C.L. Ectopic expression of the transforming growth factor b type II receptor disrupts mesoderm organisation during mouse gastrulation. Dev. Dyn. 214:141-151, 1999.

1998
Alblas, J., Slager-Davidov, R., Steenbergh, P.H., Sussenbach, J.S. and Van Der Burg, B. The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells. Oncogene 16:131-139, 1998.

Baudoin, C., Goumans, M.-J., Mummery, C. and Sonnenberg, A. Knockout and knockin of the b1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes and Dev. 12:1202-1216, 1998.

Bergwerff, M., Gittenberger-De Groot, A.C., De Ruiter, M.C., Van Iperen, L., Meijlink, F. and Poelmann, R.E. Patterns of paired-related homeobox genes PRX1 and PRX2 suggest involvement in matrix modulation in the developing chick vascular system. Dev. Dyn. 213:59-70, 1998.

Bloemers, S.M., Verheule, S., Peppelenbosch, M.P., Smit, M.J., Tertoolen, L.G.J. and De Laat, S.W. Sensitization of the histamine H1 receptor by increased ligand affinity. J.Biol.Chem. 273:2249-2255, 1998.

Buist, A., Tertoolen, L.G.J. and Den Hertog, J. Potentiation of G-protein-coupled receptor-induced MAP kinase activation by exogenous EGF receptors in SK-N-MC neuroepithelioma cells. Biochem.Biophys.Res.Comm. 251:6-10, 1998.

Caricasole, A.A.D., Van Schaik, R.H.N., Zeinstra, L.M., Wierikx, C.D.J., Van Gurp, R.J.H.L.M., Van Den Pol, M., Looijenga, L.H.J., Oosterhuis, J.W., Pera, M.F., Ward, A., De Bruijn, D., Kramer, P., De Jong, F.H. and Van Den Eijnden-Van Raaij, A.J.M. Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. Oncogene 16:95-103, 1998.

Charité, J., De Graaff, W., Consten, D., Reijnen, M.J., Korving, J. and Deschamps, J. Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements. Development 125:4349-4358, 1998.

De Graaf, M., Zivkovic, D. and Joore, J. Hormone-inducible expression of secreted factors in zebrafish embryos. Dev.Growth & Diff. 40:577-582, 1998.

De Rooij, J., Zwartkruis, F.J.T., Verheijen, M.H.G., Cool, R.H., Nijman, S.M.B., Wittinghofer, A. and Bos, J.L. Epac is a Rap 1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396:474-477, 1998.

Dumont, A., Hehner, S.P., Schmitz, M.L., Gustafsson, J.-Å., Liden, J., Okret, S., Van Der Saag, P.T., Wissink, S., Van Der Burg, B., Herrlich, P., Haegeman, G., De Bosscher, K. and Fiers, W. Cross-talk between steroids and NF-kB: what language? Trends in Biochem.Scis 23:233-235, 1998.

Durston, A.J., Van Der Wees, J., Pijnappel, W.W.M. and Godsave, S.F. Retinoids and related signals in early development of the vertebrate central nervous system. Current Top.Dev.Biol. 40:111-175, 1998.

Faust, C., Lawson, K.A., Schork, N.J., Thiel, B. and Magnuson, T. The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development 125:4495-4506, 1998.

Folkers, G.E., Van Der Burg, B. and Van Der Saag, P.T. Promoter architecture, cofactors, and orphan receptors contribute to cell-specific activation of the retinoic acid receptor b2 promoter. J.Biol.Chem. 273:32200-32212, 1998.

Gaemers, I.C., Sonneveld, E., Van Pelt, A.M.M., Schrans, B.H.G.J., Themmen, A.P.N., Van Der Saag, P.T. and De Rooij, D.G. The effect of 9-cis-retinoic acid on proliferation and differentiation of A spermatogonia and retinoid receptor gene expression in the vitamin A-deficient mouse testis. Endocrinology 139:4269-4276, 1998.

Gaemers, I.C., Van Pelt, A.M.M., Van Der Saag, P.T., Hoogerbrugge, J.W., Themmen, A.P.N. and De Rooij, D.G. Differential expression pattern of retinoid X receptors in adult murine testicular cells implies varying roles for these receptors in spermatogenesis. Biol.Reprod. 58:1351-1356, 1998.

Godsave, S.F., Koster, C.H., Getahun, A., Mathu, M., Hooiveld, M., Van Der Wees, J., Hendriks, J. and Durston, A.J. Graded retinoid responses in the developing hindbrain. Dev. Dyn. 213:39-49, 1998.

Goumans, M.-J., Ward-Van Oostwaard, D., Wianny, F., Savatier, P., Zwijsen, A. and Mummery, C. Mouse embryonic stem cells with aberrant transforming growth factor b signalling exhibit impaired differentiation in vitro and in vivo. Differentiation 63:101-113, 1998.

Gu, Z., Nomura, M., Simpson, B.B., Lei, H., Feijen, A., Van Den Eijnden-Van Raaij, A.J.M., Donahoe, P.K. and Li, E. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes and Dev. 12:844-857, 1998.

Houtzager, E. The role of connexins and the function of dorsal endoderm in embryogenesis of Xenopus laevis, Thesis, Univ. Utrecht, CD-Rom edition, 1998.

Izadyar, F., Dijkstra, G., Van Tol, H.T.A., Van Den Eijnden-Van Raaij, A.J.M., Van Den Hurk, R., Colenbrander, B. and Bevers, M.M. Immunohistochemical localization and mRNA expression of activin, inhibin, follistatin, and activin receptor in bovine cumulus-oocyte complexes during in vitro maturation. Mol.Reprod.Dev. 49:186-195, 1998.

Joore, J., Van De Water, S., Betist, M., Van Den Eijnden-Van Raaij, A.J.M. and Zivkovic, D. Protein kinase A is involved in the induction of early mesodermal marker genes by activin. Mech.of Dev. 79:5-15, 1998.

Korinek, V., Barker, N., Willert, K., Molenaar, M., Roose, J., Wagenaar, G., Markman, M., Lamers, W., Destrée, O.H.J. and Clevers, H. Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse. Mol.Cell.Biol. 18:1248-1256, 1998.

Kuil, C.W., Brouwer, A., Van Der Saag, P.T. and Van Der Burg, B. Interference between progesterone and dioxin signal transduction pathways; different mechanisms are involved in repression by the progesterone receptor A and B isoforms. J.Biol.Chem. 273:8829-8834, 1998.

Kuiper, G.G.J.M., Lemmen, J.G., Carlsson, B., Corton, J.C., Safe, S.H., Van Der Saag, P.T., Van Der Burg, B. and Gustafsson, J.-Å. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor b. Endocrinology 139:4252-4263, 1998.

Levavasseur, F., Mandemakers, W., Visser, P., Broos, L., Grosveld, F., Zivkovic, D. and Meijer, D. Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse. Mech.of Dev. 74:89-98, 1998.

Ma, R.Z., Van Eijk, M.J.T., Beever, J.E., Guérin, G., Mummery, C.L. and Lewin, H.A. Comparative analysis of 82 expressed sequence tags from a cattle ovary cDNA library. Mamm.Genome 9:545-549, 1998.

Maden, M., Sonneveld, E., Van Der Saag, P.T. and Gale, E. The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms. Development 125:4133-4144, 1998.

Molenaar, M., Roose, J., Peterson-Maduro, J., Venanzi, S., Clevers, H. and Destrée, O.H.J. Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early Xenopus development. Mech.of Dev. 75:151-154, 1998.

Mummery, C. Wat is kloneren, wat zijn klonen, wat is nieuw? In: Kloneren, edited by Hoekstra, W.P.M. and Koopman, C.R.M. Utrecht: NIBI, 1998. Verslag Symp. Kloneren, Amsterdam. pp.4-8, 1998.

Nievelstein, R.A.J., Van Der Werff, J.F.A., Verbeek, F.J., Valk, J. and Vermeij-Keers, C. Normal and abnormal embryonic development of the anorectum in human embryos. Teratology 57:70-78, 1998.

Pijnappel, W.W.M., Folkers, G.E., De Jonge, W.J., Verdegem, P.J.E., De Laat, S.W., Lugtenburg, J., Hendriks, H.F.J., Van Der Saag, P.T. and Durston, A.J. Metabolism to a response pathway selective retinoid ligand during axial pattern formation. Proc.Natn.Acad.Scis. 95:15424-15429, 1998.

Reinhart, K.C., Dubey, R.K., Mummery, C.L., Van Rooijen, M., Keller, P.J. and Rosselli, M. Synthesis and regulation of leukaemia inhibitory factor in cultured bovine oviduct cells by hormones. Mol.Hum.Reprod. 4:301-308, 1998.

Rijken, P.J., Van Hal, G.J., Van Der Heijden, M.A.G., Verkleij, A.J. and Boonstra, J. Actin polymerization is required for negative feedback regulation of epidermal growth factor-induced signal transduction. Exp.Cell Res. 243:254-262, 1998.

Roelen, B.A.J., Goumans, M.-J., Zwijsen, A. and Mummery, C.L. Identification of two distinct functions for TGF-b in early mouse development. Differentiation 64:19-31, 1998.

Roelen, B.A.J., Van Eijk, M.J.T., Van Rooijen, M.A., Bevers, M.M., Larson, J.A., Lewin, H.A. and Mummery, C.L. Molecular cloning, genetic mapping and developmental expression of a bovine TGF-b type I receptor. Mol.Reprod.Dev. 49:1-9, 1998.

Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., Van De Wetering, M., Destrée, O.H.J. and Clevers, H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395:608-612, 1998.

Shoji, H., Nakamura, T., Van Den Eijnden-Van Raaij, A.J.M. and Sugino, H. Identification of a novel type II activin receptor, type IIA-N, induced during the neural differentiation of murine P19 embryonal carcinoma cells. Biochem.Biophys.Res.Comm. 246:320-324, 1998.

Sonneveld, E., Van Den Brink, C.E., Van Der Leede, B.-J.M., Schulkes, R-K.A.M., Petkovich, M., Van Der Burg, B. and Van Der Saag, P.T. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. Cell Growth Diff. 9:629-637, 1998.

Sonneveld, E. and Van Der Saag, P.T. Metabolism of retinoic acid: implications for development and cancer. Int.J.Vit.Nutrit.Res. 68:404-410, 1998.

Ten Berge, D., Brouwer, A., El Bahi, S., Guénet, J.-L., Robert, B. and Meijlink, F. Mouse A1x3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm. Dev.Biol. 199:11-25, 1998.

Ten Berge, D., Brouwer, A., Korving, J., Martin, J.F. and Meijlink, F. Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs. Development 125:3831-3842, 1998.

Van Der Heijden, M.A.G., Rook, M.B., Hermans, M.M.P., Rijksen, G., Boonstra, J., Defize, L.H.K. and Destrée, O.H.J. Identification of connexin43 as a functional target for Wnt signalling. J.Cell Science 111:1741-1749, 1998.

Van Der Wees, J. Nuclear receptor interactions and retinoid signalling in the early Xenopus embryo, Thesis, Univ. Utrecht, 1998. pp. 1-108.

Van Der Wees, J., Schilthuis, J.G., Koster, C.H., Diesveld-Schipper, H., Folkers, G.E., Van Der Saag, P.T., Dawson, M.I., Shudo, K., Van Der Burg, B. and Durston, A.J. Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain. Development 125:545-556, 1998.

Veenstra, G.J.C., Peterson-Maduro, J., Mathu, M.T., Van Der Vliet, P.C. and Destrée, O.H.J. Non-cell autonomous induction of apoptosis and loss of posterior structures by activation domain-specific interactions of Oct-1 in the Xenopus embryo. Cell Death Diff. 5:774-784, 1998.

Venanzi, S., Destrée, O.H.J., Gigliani, F. and Battaglia, P.A. Analysis of HIV-1 Tat effects in Xenopus laevis embryos. J. Biomed. Sci. 5:211-220, 1998.

Verbeek, F.J. and Huijsmans, D.P. A graphical database for 3D reconstruction supporting (4) different geometrical representations. In: Medical Image Databases, edited by Wong, S.T.C. Boston etc.: Kluwer Acad.Publ., 1998. pp. 117-144, 1998.

Wianny, F., Real, F.X., Mummery, C.L., Van Rooijen, M., Lahti, J., Samarut, J. and Savatier, P. G1-phase regulators, cyclin D1, cyclin D2, and cyclin D3: up-regulation at gastrulation and dynamic expression during neurulation. Dev. Dyn. 212:49-62, 1998.

Wissink, S., Van Heerde, E.C., Van Der Burg, B. and Van Der Saag, P.T. A dual mechanism mediates repression of NF-kB activity by glucocorticoids. Mol.Endocrinol. 12:355-363, 1998.

1997
Baldock, R.A., Verbeek, F.J. and Vonesch, J.-L. 3D reconstructions for graphical databases of gene expression. Sem.Cell Dev.Biol. 8:499-507, 1997.

Biewenga, J.E., Destrée, O.H.J. and Schrama, L.H. Plasmid mediated gene transfer in neurons using the bolistics technique. J.Neurosci.Methods 71:67-75, 1997.

Boonstra, J., Rijken, P.J., Verkleij, A.J., Van Der Saag, P.T., Van Puijenbroek, A.F.L. and De Laat, S.W. Growth factor-induced signal transduction in mammalian cells is sensitive to gravity. In: Life Sciences Experiments performed on Sounding Rockets (1985-1994), edited by Cogoli, A., Friedrich, U., Mesland, D. and Demets, R. Noordwijk: ESA Publ.Div., 1997, p. 53-57.

Braakhuis, B.J.M., Klaassen, I., Van Der Leede, B.-J.M., Cloos, J., Brakenhoff, R.H., Copper, M.P., Teerlink, T., Hendriks, H.F.J., Van Der Saag, P.T. and Snow, G.B. Retinoid metabolism and all-trans retinoic acid-induced growth inhibition in head and neck squamous cell carcinoma cell lines. Brit.J.Cancer 76:189-197, 1997.

Brunekreef, G.A., Van Genesen, S.T., Destrée, O.H.J. and Lubsen, N.H. Extralenticular expression of Xenopus laevis a-, b-, and g-crystallin genes. Invest. Ophthalmol. Vis. Sci. 38:2764-2771, 1997.

Caricasole, A., Van Schaik, R.H.N., Zeinstra, L.M., Wierikx, C.D.J., Looijenga, L.H.J., Oosterhuis, J.W., Pera, M.F., De Jong, F.H. and Van Den Eijnden-Van Raaij, A.J.M. Analysis of the response of human embryonal carcinoma cells to activin A. In: Inhibin, Activin and Follistatin, edited by Aono, T.et al New York: Springer, 1997. Proc. Serono Symp., Tokushima, Japan, November 1996. pp.308-311,1997.

Coffer, P.J., Van Puijenbroek, A., Burgering, B.M.T., Klop-De Jonge, M., Koenderman, L., Bos, J.L. and Kruijer, W. Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction. Oncogene 15:2529-2539, 1997.

De Jong, F.H., Van Schaik, R.H.N., Wierikx, C.D.J., De Winter, J.P., Looijenga, L.H.J., Oosterhuis, J.W., Caricasole, A., Pera, M.F. and Van Den Eijnden-Van Raaij, A.J.M. Expression of inhibin subunits, follistatin, and activin receptors in normal testicular cells and testicular tumors. In: Inhibin, Activin and Follistatin, edited by Aono, T.et al New York: Springer, 1997. Proc. Serono Symp., Tokushima, Japan, November 1996. pp. 76-84, 1997.

De Winter, J.P., Roelen, B.A.J., Ten Dijke, P., Van Der Burg, B. and Van Den Eijnden-Van Raaij, A.J.M. DPC4 (SMAD4) mediates transforming growth factor-b1 (TGF-b1) induced growth inhibition and transcriptional response in breast tumor cells. Oncogene 14:1891-1899, 1997.

Dufourny, B., Alblas, J., Van Teeffelen, H.A.A.M., Van Schaik, F.M.A., Van Der Burg, B., Steenbergh, P.H. and Sussenbach, J.S. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J.Biol.Chem. 272:31163-31171, 1997.

Durston, A.J. In memory of Pieter Nieuwkoop. Development 124:759, 1997.

Durston, A.J., Van Der Wees, J., Pijnappel, W.W.M., Schilthuis, J. and Godsave, S.F. Retinoid signalling and axial patterning during early vertebrate embryogenesis. Cell.Mol.Life Scis 53:339-349, 1997.

Fanarraga, M.L., Charité, J., Hage, W.J., De Graaff, W. and Deschamps, J. Hoxb-8 gain-of-function transgenic mice exhibit alterations in the peripheral nervous system. J.Neurosci.Methods 71:11-18, 1997.

Folkers, G.E. Structure and function of retinoic acid receptors, Thesis, Univ. Utrecht, 1997. pp. 1-156.

Gaemers, I.C., Van Pelt, A.M.M., Van Der Saag, P.T., Hoogerbrugge, J.W., Themmen, A.P.N. and De Rooij, D.G. Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors a, b, and  g, and retinoid X receptors a, b, and  g in the mouse testis. Endocrinology 138:1544-1551, 1997.

Gerhart, J.C. In memoriam Pieter D. Nieuwkoop (1917-1996). Dev.Biol. 182:1-4, 1997.

Godsave, S.F. and Durston, A.J. Neural induction and patterning in embryos deficient in FGF signaling. Int.J.Dev.Biol. 41:57-65, 1997.

Grainger, R.M. and Ubbels, G.A. Early amphibian development: genes and signals involved in embryonic induction and pattern formation; introduction. Cell.Mol.Life Scis 53:303-304, 1997.

Griffini, P., Smorenburg, S.M., Verbeek, F.J. and Van Noorden, C.J.F. Three-dimensional reconstruction of colon carcinoma metastases in liver. J.Microscopy 187:12-21, 1997.

Haagmans, B.L., Teerds, K.J., Van Den Eijnden-Van Raaij, A.J.M., Horzinek, M.C. and Schijns, V.E.C.J. Transforming growth factor b production during rat cytomegalovirus infection. J.Gen.Virol. 78:205-213, 1997.

Joore, J., Timmermans, A., Van De Water, S., Folkers, G.E., Van Der Saag, P.T. and Zivkovic, D. Domains of retinoid signalling and neurectodermal expression of zebrafish otx1 and goosecoid are mutually exclusive. Biochem.Cell Biol. 75:601-612, 1997.

Joun, H., Lanske, B., Karperien, M., Qian, F., Defize, L.H.K. and Abdul-Badi Abou-Samra.  Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor gene: a new PTH/PTHrP receptor splice variant that lacks the signal peptide. Endocrinology 138:1742-1749, 1997.  

Karperien, M., Farih-Sips, H., Löwik, C.W.G.M., De Laat, S.W., Boonstra, J. and Defize, L.H.K. Expression of the parathyroid hormone-related peptide gene in retinoic acid-induced differentiation: involvement of ETS and Sp1. Mol.Endocrinol. 11:1435-1448, 1997.

Kester, H.A., Van Der Leede, B.-J.M., Van Der Saag, P.T. and Van Der Burg, B. Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. J.Biol.Chem. 272:16637-16643, 1997.

Martens, J.W.M., De Winter, J.P., Timmerman, M.A., McLuskey, A., Van Schaik, R.H.N., Themmen, A.P.N. and De Jong, F.H. Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. Endocrinology 138:2928-2936, 1997.

McDevitt, D.S., Brahma, S.K., Courtois, Y. and Jeanny, J.-C. Fibroblast growth factor receptors and regeneration of the eye lens. Dev. Dyn. 208:220-226, 1997.

Nieuwkoop, P.D. Short historical survey of pattern formation in the endo-mesoderm and the neural anlage in the vertebrates: the role of vertical and planar inductive actions. Cell.Mol.Life Scis 53:305-318, 1997.

Palecek, J. and Ubbels, G.A. Dynamic changes in the tubulin cytoskeleton during oogenesis and early development in the anuran amphibian Xenopus laevis (Daudin). Fol.Histochem.Cytobiol. 35:3-18, 1997.

Roelen, B.A.J. TGF-bs and their receptors in early mammalian development, Thesis, Univ. Utrecht, 1997. pp. 1-148.

Roelen, B.A.J., Goumans, M.-J., Van Rooijen, M.A. and Mummery, C.L. Differential expression of BMP receptors in early mouse development. Int.J.Dev.Biol. 41:541-549, 1997.

Roelen, B.A.J., Van Rooijen, M.A. and Mummery, C.L. Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development. Dev. Dyn. 209:418-430, 1997 

Schootemeijer, A., Van Willigen, G., Van Der Vuurst, H., Tertoolen, L.G.J., De Laat, S.W. and Akkerman, J.-W.N. Lateral mobility of integrin allbb3 (glycoprotein llb/llla) in the plasma membrane of a human megakaryocyte. Thromb.Haemostasis 77:143-149, 1997.

Schrama, L.H., Lepperdinger, G., Moritz, A., Van Den Engel, N.K., Marquart, A., Oestreicher, A.B., Eggen, B.J.L., Hage, W.J., Richter, K. and Destrée, O.H.J. B-50/growth-associated protein-43, a marker of neural development in Xenopus laevis. Neuroscience 76:635-652, 1997.

Speksnijder, J.E., Hage, W.J., Lanser, P.H., Collodi, P. and Zivkovic, D. In vivo assay for the developmental competence of embryo-derived zebrafish cell lines. Mol.Marine Biol.Biotechnol. 6:21-32, 1997.

Ubbels, G.A. Establishment of polarities in the oocyte of Xenopus laevis; the provisional axial symmetry of the full-grown oocyte of Xenopus laevis. Cell.Mol.Life Scis 53:382-409, 1997.

Ubbels, G.A. Fertilisation and development of Xenopus eggs on sounding rockets and in a clinostat. In: Life Sciences Experiments performed on Sounding Rockets (1985-1994), edited by Cogoli, A., Friedrich, U., Mesland, D. and Demets, R. Noordwijk: ESA Publ. Div., 1997. pp. 25-35, 1997.

Valarché, I., De Graaff, W. and Deschamps, J. A 3' remote control region is a candidate to modulate Hoxb-8 expression boundaries. Int.J.Dev.Biol. 41:705-714, 1997.

Van Delft, S., Schumacher, C., Hage, W., Verkleij, A.J. and Van Bergen en Henegouwen, P.M.P. Association and colocalization of Eps15 with adaptor protein-2 and clathrin. J.Cell Biol. 136:811-821, 1997.

Van Der Burg, B., Liden, J., Okret, S., Delaunay, F., Wissink, S., Van Der Saag, P.T. and Gustafsson, J.-Å. Nuclear factor-k B repression in antiinflammation and immunosuppression by glucocorticoids. Trends in Endocrinol.Metab. 8:152-157, 1997.

Van Der Flier, A., Gaspar, A.C., Thorsteinsd¢ttir, S., Baudoin, C., Groeneveld, E., Mummery, C.L. and Sonnenberg, A. Spatial and temporal expression of the B1D integrin during mouse development. Dev. Dyn. 210:472-486, 1997.

Van Der Leede, B.-J.M., Van Den Brink, C.E., Pijnappel, W.W.M., Sonneveld, E., Van Der Saag, P.T. and Van Der Burg, B. Autoinduction of retinoic acid metabolism to polar derivatives with decreased biological activity in retinoic acid-sensitive, but not in retinoic acid-resistant human breast cancer cells. J.Biol.Chem. 272:17921-17928, 1997.

Van Der Leede, B.-J.M. and Vroom, T.M. Retinoïden: toepassing bij de bestrijding van kanker. Ned.Tijdschr.Geneesk. 141:1183-1188, 1997.

Van Der Saag, P.T., Van Puijenbroek, A.F.L. and De Laat, S.W. Growth factor-induced signal transduction in mammalian cells is sensitive to gravity. In: Life Sciences Experiments performed on Sounding Rockets (1985-1994), edited by Cogoli, A., Friedrich, U., Mesland, D. and Demets, R. Noordwijk: ESA Publ.Div., 1997. pp. 53-57, 1997.

Van Inzen, W.G. Receptor protein tyrosine phosphatase a and neuronal differentiation, Thesis, Univ. Utrecht, 1997. pp. 1-114.

Van Puijenbroek, A. Signal transduction by distinct neurotrophic receptors, Thesis, Univ. Utrecht, 1997. pp. 1-134.

Van Puijenbroek, A.A.F.L., Van Weering, D.H.J., Van Den Brink, C.E., Bos, J.L., Van Der Saag, P.T., De Laat, S.W. and Den Hertog, J. Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation. Oncogene 14:1147-1157, 1997.

Veenstra, G.J.C., Van Der Vliet, P.C. and Destrée, O.H.J. POU domain transcription factors in embryonic development. Mol.Biol.Rep. 24:139-155, 1997.

Verheijen, M.H.G. Signal transduction by the PTH/PTHrP receptor; its role in parietal endoderm differentiation, Thesis, Univ. Utrecht, 1997. pp. 1-128.

Verheijen, M.H.G. and Defize, L.H.K. Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras. J.Biol.Chem. 272:3423-3429, 1997.

Westin, S., Sonneveld, E., Van Der Leede, B.-J.M., Van Der Saag, P.T., Gustafsson, J.-Å. and Mode, A. CYP2C7 expression in rat liver and hepatocytes: regulation by retinoids. Mol.Cell.Endocrinol. 129:169-179, 1997.

Wissink, S. A mechanism for the anti-inflammatory action of glucocorticoids; repression of transcription factor NF-kB activity, Thesis, Univ. Utrecht, 1997. pp. 1-128.

Wissink, S., Van De Stolpe, A., Caldenhoven, E., Koenderman, L. and Van Der Saag, P.T. NF-kB/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells. Immunobiology 198:50-64, 1997.

Wissink, S., Van Heerde, E.C., Schmitz, M.L., Kalkhoven, E., Van Der Burg, B., Baeuerle, P.A. and Van Der Saag, P.T. Distinct domains of the Re1A NF-kB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. J.Biol.Chem. 272:22278-22284, 1997.

Wu, L., Buist, A., Den Hertog, J. and Zhang, Z.-Y. Comparative kinetic analysis and substrate specificity of the tandem catalytic domains of the receptor-like protein-tyrosine phosphatase a. J.Biol.Chem. 272:6994-7002, 1997.

1996
Ameerun, R.F., De Winter, J.P., Van Den Eijnden-Van Raaij, A.J.M., Den Hertog, J., De Laat, S.W. and Tertoolen, L.G.J. Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells. Cell Growth Diff. 7:1679-1688, 1996.

Bilwes, A.M., Den Hertog, J., Hunter, T. and Noel, J.P. Structural basis for inhibition of receptor protein-tyrosine phosphatase-a by dimerization. Nature 382:555-559, 1996.

De Mazière, A., Gonzalez-Jurado, J., Reijnen, M., Narraway, J. and Ubbels, G.A. Transient effects of microgravity on early embryos of Xenopus laevis. Adv.Space Res. 17:219-223, 1996.

De Mazière, A.M., Hage, W.J. and Ubbels, G.A. A method for staining of cell nuclei in Xenopus laevis embryos with cyanine dyes for whole-mount confocal laser scanning microscopy. J.Histochem.Cytochem. 44:399-402, 1996.

De Vries, C.J.M., De Boer, J., Joore, J., Strühle, U., Van Achterberg, T.A.E., Huylebroeck, D., Verschueren, K., Miyazono, K., Van Den Eijnden-Van Raaij, A.J.M. and Zivkovic, D. Active complex formation of type I and type II activin and TGFb receptors in vivo as studied by overexpression in zebrafish embryos. Mech.of Dev. 54:225-236, 1996.

De Winter, J.P., De Vries, C.J.M., Van Achterberg, T.A.E., Ameerun, R.F., Feijen, A., Sugino, H., De Waele, P., Huylebroeck, D., Verschueren, K. and Van Den Eijnden-Van Raaij, A.J.M. Truncated activin type II receptors inhibit activin bioactivity by the formation of heteromeric complexes with activin type I receptors. Exp.Cell Res. 224:323-334, 1996.

De Winter, J.P., Ten Dijke, P., De Vries, C.J.M., Van Achterberg, T.A.E., Sugino, H., De Waele, P., Huylebroeck, D., Verschueren, K. and Van Den Eijnden-Van Raaij, A.J.M. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors. Mol.Cell.Endocrinol. 116:105-114, 1996.

Den Hertog, J. and Hunter, T. Tight association of GRB2 with receptor protein-tyrosine phosphatase a is mediated by the SH2 and C-terminal SH3 domains. EMBO J. 15:3016-3027, 1996.

Den Hertog, J., Overvoorde, J. and De Laat, S.W. Expression of receptor protein-tyrosine phosphatase a mRNA and protein during mouse embryogenesis. Mech.of Dev. 58:89-101, 1996.

Durston, A.J., Van Der Wees, J., Godsave, S.F., Pijnappel, W.W.M. and Schilthuis, J.G. Retinoid signalling in the vertebrate embryo. Neth.J.Zool. 46:68-90, 1996.

Folkers, G.E., Van Der Burg, B. and Van der Saag, P.T A role for cofactors in synergistic and cell-specific activation by retinoic acid receptors and retinoid X receptor. J.Steroid Biochem.Mol.Biol. 56:119-129, 1996.

Gaemers, I.C., Van Pelt, A.M.M., Van Der Saag, P.T. and De Rooij, D.G. All-trans-4-oxo-retinoic acid: a potent inducer of in vivo proliferation of growth-arrested A spermatogonia in the vitamin A-deficient mouse testis. Endocrinology 137:479-485, 1996.

Gutknecht, D.R. Intracellular pH regulation and anterior-posterior patterning during Xenopus development, Thesis, Univ. Utrecht, 1996. pp. 1-160.

Hierck, B.P., Gittenberger-De Groot, A.C., Van Iperen, L., Brouwer, A. and Poelmann, R.E. Expression of the b4 integrin subunit in the mouse heart during embryonic development: retinoic acid advances b4 expression. Dev. Dyn. 207:89-103, 1996.

Hierck, B.P., Poelmann, R.E., Van Iperen, L., Brouwer, A. and Gittenberger-De Groot, A.C. Differential expression of a6 and other subunits of laminin binding integrins during development of the murine heart. Dev. Dyn. 206:100-111, 1996.

Joore, J., Fasciana, C., Speksnijder, J.E., Kruijer, W., Destrée, O.H.J., Van Den Eijnden-Van Raaij, A.J.M., De Laat, S.W. and Zivkovic, D. Regulation of the zebrafish goosecoid promoter by mesoderm inducing factors and Xwnt1. Mech.of Dev. 55:3-18, 1996.

Kalkhoven, E., Beraldi, E., Panno, M.L., De Winter, J.P., Thijssen, J.H.H. and Van Der Burg, B. Growth inhibition by anti-estrogens and progestins in TGF-b-resistant and -sensitive breast-tumor cells. Int.J.Cancer 65:682-687, 1996.

Kalkhoven, E., Wissink, S., Van Der Saag, P.T. and Van Der Burg, B. Negative interaction between the Re1A (p65) subunit of NF-kB and the progesterone receptor. J.Biol.Chem. 271:6217-6224, 1996.

Karperien, M., Lanser, P., De Laat, S.W., Boonstra, J. and Defize, L.H.K. Parathyroid hormone related peptide mRNA expression during murine postimplantation development: evidence for involvement in multiple differentiation processes. Int.J.Dev.Biol. 40:599-608, 1996.

Koster, J.G., Eizema, K., Peterson-Maduro, L.J., Stegeman, B.I. and Destrée, O.H.J. Analysis of Wnt/Engrailed signaling in Xenopus embryos using biolistics. Dev.Biol. 173:348-352, 1996.

Lanske, B., Karaplis, A.C., Lee, K., Luz, A., Vortkamp, A., Pirro, A., Karperien, M., Defize, L.H.K., Ho, C., Mulligan, R.C., Abdul-Badi Abou-Samra, , Jüppner, H., Segre, G.V. and Kronenberg, H.M. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273:663-666, 1996.

Magun, R., Burgering, B.M.T., Coffer, P.J., Pardasani, D., Lin, Y., Chabot, J. and Sorisky, A. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137:3590-3593, 1996.

Molenaar, M., Van De Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destr&Mac226;e, O.H.J. and Clevers, H. XTcf-3 transcription factor mediates b-catenin-induced axis formation in Xenopus embryos. Cell 86:391-399, 1996.

Nieuwkoop, P.D. What are the key advantages and disadvantages of urodele species compared to anurans as a model system for experimental analysis of early development? Int.J.Dev.Biol. 40:617-619, 1996.

Nieuwkoop, P.D., Björklund, N.K. and Gordon, R. Surface contraction and expansion waves correlated with differentiation in axolotl embryos. II. In contrast to urodeles, the anuran Xenopus laevis does not show furrowing surface contraction waves. Int.J.Dev.Biol. 40:661-664, 1996.

Peppelenbosch, M.P., Tertoolen, L.G.J., De Vries-Smits, A.M.M., Qiu, R.-G., Rabet, L.M., Symons, M.H., De Laat, S.W. and Bos, J.L. Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx. J.Biol.Chem. 271:7883-7886, 1996.

Pijnappel, W.W.M., Hendriks, H.F.J. and Durston, A.J. Retinoid signalling during embryogenesis. Europ.J.Clin.Nutrit. 50, suppl.3:S29--S31, 1996.

Tilly, B.C., Edixhoven, M.J., Tertoolen, L.G.J., Morii, N., Saitoh, Y., Narumiya, S. and De Jonge, H.R. Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton. Mol.Biol.Cell 7:1419-1427, 1996.

Van De Stolpe, A., Jacobs, N., Hage, W.J., Tertoolen, L.G.J., Van Kooyk, Y., Nováková, I.R.O. and De Witte, T. Fibrinogen binding to ICAM-1 on EA.hy 926 endothelial cells is dependent on an intact cytoskeleton. Thromb.Haemostasis 75:182-189, 1996.

Van De Stolpe, A. and Van Der Saag, P.T. Intercellular adhesion molecule-1. J.Mol.Med. 74:13-33, 1996.

Van Der Burg, B. Regulation of breast tumor proliferation and gene expression by progestins; the role of progesterone receptor/nuclear factor-kappa-B interactions. In: In Vitro Biology of Sex Steroid Hormone Action, edited by Kuramoto, H. and Gurpide, E. Tokyo: Churchill-Livingstone, 1996. Proc. 1st Intern.Symp., Tokyo, November 1995. pp. 307-322, 1996.

Van Der Burg, B. and Van Der Saag, P.T. Nuclear factor-kappa-B/steroid hormone receptor interactions as a functional basis of anti-inflammatory action of steroids in reproductive organs. Mol.Hum.Reprod. 2:433-438, 1996.

Van Der Leede, B.-J.M., Geertzema, J., Vroom, T.M., Décimo, D., Lutz, Y., Van Der Saag, P.T. and Van Der Burg, B. Immunohistochemical analysis of retinoic acid receptor a in human breast tumors. Am.J.Pathol. 148:1905-1914, 1996.

Van Der Lugt, N.M.T., Alkema, M., Berns, A. and Deschamps, J. The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech.of Dev. 58:153-164, 1996.

Van Der Saag, P.T. Nuclear retinoid receptors: mediators of retinoid effects. Europ.J.Clin.Nutrit. 50, suppl. 3:S24-S28, 1996.

Van Der Saag, P.T., Caldenhoven, E. and Van De Stolpe, A. Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kB transcription factors. Europ.Resp.J. 9, suppl.22:S146-S153, 1996.

Van Der Wees, J., Matharu, P.J., De Roos, K., Destrée, O.H.J., Godsave, S.F., Durston, A.J. and Sweeney, G.E. Developmental expression and differential regulation by retinoic acid of Xenopus COUP-TF-A and COUP-TF-B. Mech.of Dev. 54:173-184, 1996.

Van Eijk, M.J.T., Mandelbaum, J., Salat-Baroux, J., Belaisch-Allart, J., Plachot, M., Junca, A.M. and Mummery, C.L. Expression of leukaemia inhibitory factor receptor subunits LIFRb and gp130 in human oocytes and preimplantation embryos. Mol.Hum.Reprod. 2:355-360, 1996.

Van Inzen, W.G., Peppelenbosch, M.P., Van Den Brand, M.W.M., Tertoolen, L.G.J. and De Laat, S.W. Neuronal differentiation of embryonic stem cells. Biochim.Biophys.Acta 1312:21-26, 1996.

Van Inzen, W.G., Peppelenbosch, M.P., Van Den Brand, M.W.M., Tertoolen, L.G.J. and De Laat, S.W. The role of receptor protein tyrosine phosphatase a in neuronal differentiation of embryonic stem cells. Dev.Brain Res. 91:304-307, 1996.

Van Tol, H.T.A., Van Eijk, M.J.T., Mummery, C.L., Van Den Hurk, R. and Bevers, M.M. Influence of FSH and hCG on the resumption of meiosis of bovine oocytes surrounded by cumulus cells connected to membrana granulosa. Mol.Reprod.Dev. 45:218-224, 1996.

Veenstra, G.J.C. Oct-1 in Xenopus embryonic development, Thesis, Univ. Utrecht, 1996. pp. 1-124.

Verbeek, F.J. 3-D reconstruction from serial sections: applications and limitations. Microscop.Anal. november issue:33-35, 1996.

Zanotti, M., Poli, G., Ponti, W., Polli, M., Rocchi, M., Bolzani, E., Longeri, M., Russo, S., Lewin, H.A. and Van Eijk, M.J.T. Association of BoLA class II haplotypes with subclinical progression of bovine leukaemia virus infection in Holstein-Friesian cattle. Anim.Genet. 27:337-341, 1996.

Zwijsen, R.M.L., Klompmaker, R., Wientjens, E.B.H.G.M., Kristel, P.M.P., Van Der Burg, B. and Michalides, R.J.A.M. Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit. Mol.Cell.Biol. 16:2554-2560, 1996.