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Hubrecht publications

1996   1997   1998   1999   2000

Blanchetot, C. Dimerization of receptor protein-tyrosine phosphatases; characterization of RPTPa interacting proteins, Thesis, Univ. Utrecht, 2000. pp. 1-144.

Blanchetot, C. and Den Hertog, J. Antibody-induced dimerization of HARPTPa/EGFR chimera suggests a ligand dependent mechanism of regulation for RPTPa . Febs Lett. 484: 235-240, 2000. 

Blanchetot, C. and Den Hertog, J. Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) a and membrane-distal protein-tyrosine phosphatase domains of various RPTPs. J. Biol. Chem. 275: 12446-12452, 2000.

Boon, P.J., Eminovi?, N., De Vos, A., Buitendijk, B., Van Raaij, E.J., Den Broeder, M.J., Hage, W.J. and Verbeek, F.J. A virtual lab-notebook for multidimensional microscope images. In: Information Visualisation, edited by Banissi, E. et al. Los Alamitos: IEEE Computer Soc., 2000. Proc. 2000 IEEE Conf. on Information Visualisation, London. pp. 187-191, 2000.

Braat, A.K., Van De Water, S., Goos, H., Bogerd, J. and Zivkovic, D. Vasa protein expression and localization in the zebrafish. Mech. of Dev.  95: 271-274, 2000.

Buist, A., Blanchetot, C. and Den Hertog, J. Involvement of the membrane distal catalytic domain in pervanadate-induced tyrosine phosphorylation of receptor protein-tyrosine phosphatase a.  Biochem. Biophys. Res. Comm. 267: 96-102, 2000.

Buist, A., Blanchetot, C., Tertoolen, L.G.J. and Den Hertog, J. Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase a. J. Biol. Chem. 275: 20754-20761, 2000.

Caricasole, A., Ward-Van Oostwaard, D., Mummery, C. and Van Den Eijnden-Van Raaij, A. Bone morphogenetic proteins and retinoic acid induce human endogenous retrovirus HERV-K expression in NT2D1 human embryonal carcinoma cells. Dev. Growth Diff. 42: 407-411, 2000.

Caricasole, A., Ward-Van Oostwaard, D., Zeinstra, L., Van Den Eijnden-Van Raaij, A. and Mummery, C. Bone morphogenetic proteins (BMPs) induce epithelial differentiation of NT2D1 human embryonal carcinoma cells. Int. J. Dev. Biol. 44: 443-450, 2000.

De Groot, E. Genes regulated during ectodermal patterning of the mouse embryo at gastrulation, Thesis, Univ. Utrecht, 2000. pp. 1-118.

De Groot, E., Feijen, A., Eib, D., Zwijsen, A., Sugino, H., Martens, G. and Van Den Eijnden-Van Raaij, A.J.M. Expression patterns of follistatin and two follistatin-related proteins during mouse development. Int. J. Dev. Biol. 44: 327-330, 2000.

De Groot, E., Veltmaat, J.M., Caricasole, A., Defize, L.H.K. and Van Den Eijnden-Van Raaij, A.J.M. Cloning and analysis of the mouse follistatin promoter. Mol. Biol. Rep. 27: 129-139, 2000.

Eib, D.W., Holling, T.M., Zwijsen, A., Dewulf, N., De Groot, E., Van Den Eijnden-Van Raaij, A.J.M., Huylebroeck, D. and Martens, G.J.M. Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. Mech. of Dev. 97: 167-171, 2000.

Eijkelenboom, A.P.A.M., Van Den Ent, F.M.I., Wechselberger, R., Plasterk, R.H.A., Kaptein, R. and Boelens, R. Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase. J. Biomol.NMR 18:119-128, 2000.

García-Sáez, I. and Plasterk, R.H.A. Purification of the Caenorhabditis elegans transposase Tc1A refolded during gel filtration chromatography. Protein Expres. Purif. 19: 355-361, 2000.

Goumans, M.-J. and Mummery, C. Functional analysis of the TGFb receptor/Smad pathway through gene ablation in mice. Int. J. Dev. Biol. 44: 253-265, 2000.

Holling, T.M., Van Herp, F. Durston, A.J. and Martens, G.J.M. Differential onset of expression of mRNAs encoding proopiomelanocortin, prohormone convertases 1 and 2, and granin family members during Xenopus laevis development. Mol. Brain Res. 75: 70-75, 2000.

Izsvák, Z., Ivics, Z. and Plasterk, R.H.A. Sleeping beauty, a wide host-range transposon vector for genetic transformation in vertebrates. J. Mol. Biol. 302:93-102, 2000.

Jansen, G., Thijssen, K.L., Werner, P., Van Der Horst, M., Hazendonk, E. and Plasterk, R.H.A. The heterotrimeric G protein genes of Caenorhabditis elegans. In: Ernst Schering Research Foundation Workshop 29, edited by Stock, G. Berlin: Springer, 2000, p. 13-34.

Jiang, G., Den Hertog, J. and Hunter, T. Receptor-like protein tyrosine phosphatase a homodimerizes on the cell surface. Mol. Cell. Biol. 20: 5917-5929, 2000.

Kester, H.A., Ward-Van Oostwaard, T.M.J., Goumans, M.-J., Van Rooijen, M.A., Van Der Saag, P.T., Van Der Burg, B. and Mummery, C.L. Expression of TGF-b stimulated clone-22 (TSC-22) in mouse development and TGF-b signalling. Dev. Dyn. 218: 563-572, 2000.

Ketting, R.F. Regulation of transposon activity in the germline of Caenorhabditis elegans, Thesis, Univ. Utrecht, 2000. pp. 1-106.

Ketting, R.F. and Plasterk, R.H.A. A genetic link between co-suppression and RNA interference in C. elegans. Nature 404:296-298, 2000.

Koch, R., Van Luenen, H.G.A.M., Van Der Horst, M. , Thijssen, K.L. and Plasterk, R.H.A. Single nucleotide polymorphisms in wild isolates of Caenorhabditis  elegans. Genome Res. 10: 1690-1696, 2000.

Korswagen, H.C. and Clevers, H.C. Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. Cold Spring Harb. Symp. Quant. Biol. 64:141-147, 2000.

Korswagen, H.C., Herman, M.A. and Clevers, H.C. Distinct b-catenins mediate adhesion and signalling functions in C. elegans. Nature 406:527-532, 2000.

Legler, J., Broekhof, J.L.M., Brouwer, A., Lanser, P.H., Murk, A.J., Van Der Saag, P.T., Vethaak, A.D., Wester, P., Zivkovic, D. and Van Der Burg, B. A novel in vivo bioassay for (xeno-)estrogens using transgenic zebrafish. Environm. Sci. Toxicol. 34: 4439-4444, 2000.  

Molenaar, M. A dual action of XTcf-3 in body axis formation, Thesis, Univ. Utrecht, 2000. pp. 1-104.

Molenaar, M., Brian, E., Roose, J., Clevers, H. and Destrée. O. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mech. of Dev. 91: 311-315, 2000.

Morgan, R., In Der Rieden, P., Hooiveld, M.H.W. and Durston, A.J. Identifying Hox paralog groups by the PBX-binding region. Trends in  Genet. 16: 66-67, 2000.

Motley, A.M., Hettema, E.H., Ketting, R., Plasterk, R.H.A. and Tabak, H.F. Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes. Embo Rep. 1: 40-46, 2000.

Nielsen, M., Høyer, P.E., Lemmen, J.G., Van Der Burg, B. and Byskov, A.G. Octylphenol does not mimic diethylstilbestrol-induced oestrogen receptor-a expression in the newborn mouse uterine epithelium after prenatal exposure. J. Endocrinol. 167: 29-37, 2000.

Odenthal, J., Van Eeden, F.J., Haffter, P., Ingham, P.W., Nüsslein-Volhard, C. Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219:350-363, 2000.

Pilon, M., Peng, X.-R., Spence, A.M., Plasterk, R.H.A. and Dosch, H.-M. The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Mol. Biol. Cell 11: 3277-3288, 2000.

Plasterk, R.H.A. and Ketting, R.F. The silence of the genes. Curr. Op. Genet. Dev. 10:562-567, 2000.

Roelen, B.A.J. and Mummery, C.L. Transforming growth factor-bs in pre-gastrulation development of mammals. Mol. Reprod.Dev. 56: 220-226, 2000.

Schubert, C.M., Lin, R., De Vries, C.J., Plasterk, R.H.A. and Priess, J.R. Mex-5 and mex-6 function to establish soma/germline asymmetry in early C. elegans embryos. Mol. Cell 5: 671-682, 2000.

Van Der Heyden, M.A.G., Veltmaat, J.M., Hendriks, J.A.A., Destrée, O.H.J. and Defize, L.H.K. Dynamic connexin43 expression and gap junctional communication during endoderm differentiation of F9 embryonal carcinoma cells. Europ. J. Cell Biol. 79: 272-282, 2000.

Van Der Velden, A.W., Destrée, O.H.J., Voorma, H.O. and Thomas, A.A.M. Controlled translation initiation on insulin-like growth factor 2-leader 1 during Xenopus laevis embryogenesis. Int. J. Dev. Biol. 44: 843-850, 2000.

Veltmaat, J.M., Orelio, C.C., Ward-Van Oostwaard, D., Van Rooijen, M.A., Mummery, C.L. and Defize, L.H.K. Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation. Int. J. Dev. Biol. 44: 297-307, 2000.

Verbeek, F.J. Three-dimensional (3D) reconstruction from serial sections. In: Image Processing and Analysis, edited by Baldock, R. and Graham, J. Oxford: Univ. Press, 2000. The Practical Approach Series. pp. 153-195, 2000.

Verbeek, F.J., Den Broeder, M.J., Boon, P.J., Buitendijk, B., Doerry, E., Van Raaij, E.J. and Zivkovic, D. A standard 3D digital atlas of zebrafish embryonic development for projection of experimental data. In: Proceedings IS and T/SPIE Conf. on Internet Imaging. San Jose, Cal., 2000. SPIE Proceedings Series 3964: 242-252, 2000.

Wicks, S.R., De Vries, C.J., Van Luenen, H.G.A.M. and Plasterk, R.H.A. CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans. Dev. Biol. 221: 295-307, 2000.

Wissink, S., Meijer, O., Pearce, D., Van Der Burg, B. and Van Der Saag, P.T. Regulation of the rat serotonin-1A receptor gene by corticosteroids. J. Biol. Chem. 275: 1321-1326, 2000.

Ying, Y., Liu, X., Marble, A., Lawson, K.A. and  Zhao, G.Q. Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Mol. Endocrinol. 14: 1053-1063, 2000.

Zomer, A.W.M., Jansen, G.A., Van Der Burg, B., Verhoeven, N.M., Jakobs, C., Van Der Saag, P.T., Wanders, R.J.A. and Poll-The, B.T. Phytanoyl-CoA hydroxylase activity is induced by phytamic acid. Europ. J. Biochem. 267: 4063-4067, 2000.

Zomer, A.W.M., Van Der Burg, B., Jansen, G.A., Wanders, R.J.A., Poll-The, B.T. and Van Der Saag, P.T. Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor a.  J. Lipid Res. 41: 1801-1807, 2000.

Zwijsen, A., Van Rooijen, M.A., Goumans, M.-J., Dewulf, N., Bosman, E.A., Ten Dijke, P., Mummery, C.L. and Huylebroeck, D. Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis. Dev. Dyn. 218: 663-670, 2000.


Braat, A.K. Characterization of germ line development in zebrafish; molecular and functional aspects, Thesis, Univ. Utrecht, 1999. pp. 1-122.

Braat, A.K., Speksnijder, J.E., and Zivkovic, D. Germ line development in fishes. Int.J.Dev.Biol. 43:745-760, 1999.

Braat, A.K., Zandbergen, M.A., De Vries, E., Van Der Burg, B., Bogerd, J. and Goos, H.J.T. Cloning and expression of the zebrafish germ cell nuclear factor. Mol.Reprod.Dev. 53:369-375, 1999.

Braat, A.K., Zandbergen, T., Van De Water, S., Goos, H.J.T. and Zivkovic, D. Characterization of zebrafish primordial germ cells: morphology and early distribution of vasa RNA. Dev. Dyn. 216:153-167, 1999.

Buist, A. Characterization of receptor protein-tyrosine phosphatase a, Thesis, Univ. Utrecht, 1999. pp. 1-152.

Buist, A., Zhang, Y.-L., Keng, Y.-F., Wu, L., Zhang, Z.-Y. and Den Hertog, J. Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase a. Biochemistry 38:914-922, 1999.

De Laat, S.W., Boonstra, J., Defize, L.H.K., Kruijer, W., Van Der Saag, P.T., Tertoolen, L.G.J., Van Zoelen, E.J.J. and Den Hertog, J. Growth factor signalling. Int.J.Dev.Biol. 43:681-691, 1999.

De Roos, K., Sonneveld, E., Compaan, B., Ten Berge, D., Durston, A.J. and Van Der Saag, P.T. Expression of retinoic acid 4-hydroxylase (CYP26) during mouse and Xenopus laevis embryogenesis. Mech.of Dev. 82:205-211, 1999.

Den Hertog, J. Protein-tyrosine phosphatases in development. Mech.of Dev. 85:3-14, 1999.

Den Hertog, J., Blanchetot, C., Buist, A., Overvoorde, J., Van Der Sar, A. and Tertoolen, L.G.J. Receptor protein-tyrosine phosphatase signalling in development. Int.J.Dev.Biol. 43:723-733, 1999.

Deschamps, J., Van Den Akker, E., Forlani, S., De Graaff, W., Oosterveen, T., Roelen, B. and Roelfsema, J. Initiation, establishment and maintenance of Hox gene expression patterns in the mouse. Int.J.Dev.Biol. 43:635-650, 1999.

Durston, A.J. Discovery of a morphogen. Int.J.Dev.Biol. 43:625-627, 1999.

Durston, A.J.(Ed) The Hubrecht Laboratory: The Netherlands Institute for Developmental Biology; Special Issue. Int.J.Dev.Biol. 43,no.7, pp.579-776, 1999.

Faasse, P., Faber, J. and Narraway, J. A brief history of the Hubrecht Laboratory. Int.J.Dev.Biol. 43:583-590, 1999.

Goumans, M.-J. Functional analysis of TGFb signalling in early mouse development, Thesis, Univ.Utrecht, 1999. pp. 1-152.

Goumans, M.-J., Zwijsen, A., Van Rooijen, M.A., Huylebroeck, D., Roelen, B.A.J. and Mummery, C.L. Transforming growth factor-b signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice. Development 126:3473-3483, 1999.

Gu, Z., Reynolds, E.M., Song, J., Lei, H., Feijen, A., Yu, L., He, W., MacLaughlin, D.T., Van Den Eijnden-Van Raaij, J., Donahoe, P.K. and Li, E. The type I serine/threonine kinase receptor ActRlA (ALK2) is required for gastrulation of the mouse embryo. Development 126:2551-2561, 1999.

Hooiveld, M.H.W. Establishment of the neuraxis in Xenopus laevis, Thesis, Univ. Utrecht, 1999. pp. 1-116.

Hooiveld, M.H.W., Morgan, R., In Der Rieden, P., Houtzager, E., Pannese, M., Damen, K., Boncinelli, E. and Durston, A.J. Novel interactions between vertebrate Hox genes. Int.J.Dev.Biol. 43:665-674, 1999.

Jiang, G., Den Hertog, J., Su, J., Noel, J., Sap, J. and Hunter, T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-a. Nature 401:606-610, 1999.

Jonkers, J., Van Amerongen, R., Van Der Valk, M., Robanus-Maandag, E., Molenaar, M., Destrée, O.H.J. and Berns, A. In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3. Mech.of Dev. 88:183-194, 1999.

Joore, J. Promoter analysis in zebrafish embryos. In: Molecular Methods in Developmental Biology: Xenopus and Zebrafish, edited by Guille, M. Totowa, N.J.: Humana Press, 1999. Methods in Molecular Biology 127: 155-166, 1999.

Karperien, M., Farih-Sips, H., Hendriks, J.A.A., Lanske, B., Papapoulos, S.E., Abdul-Badi Abou-Samra, , Löwik, C.W.G.M. and Defize, L.H.K. Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene. Mol.Endocrinol. 13:1183-1196, 1999.

Kester, H.A. Progestin action in human breast- and endometrial tumor cells: role of progesterone target gene TSC-22, Thesis, Univ. Utrecht, 1999. pp. 1-108.

Kester, H.A., Blanchetot, C., Den Hertog, J., Van Der Saag, P.T. and Van Der Burg, B. Transforming growth factor-b-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. J.Biol.Chem. 274:27439-27447, 1999.

Lawson, K.A. Fate mapping the mouse embryo. Int.J.Dev.Biol. 43:773-775, 1999.

Lawson, K.A., Dunn, N.R., Roelen, B.A.J., Zeinstra, L.M., Davis, A.M., Wright, C.V.E., Korving, J.P.W.F.M. and Hogan, B.L.M. Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes and Dev. 13:424-436, 1999.

Legler, J., Van Den Brink, C.E., Brouwer, A., Murk, A.J., Van Der Saag, P.T., Vethaak, A.D. and Van Der Burg, B. Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol.Scis 48:55-66, 1999.

Lemmen, J.G., Broekhof, J.L.M., Kuiper, G.G.J.M., Gustafsson, J.-Å., Van Der Saag, P.T. and Van Der Burg, B. Expression of estrogen receptor alpha and beta during mouse embryogenesis. Mech.of Dev. 81:163-167, 1999.

Meijlink, F., Beverdam, A., Brouwer, A., Oosterveen, T.C. and Ten Berge, D. Vertebrate aristaless-related genes. Int.J.Dev.Biol. 43:651-663, 1999.

Molenaar, M. and Destrée, O.H.J. A tight control over Wnt action. Int.J.Dev.Biol. 43:675-680, 1999.

Morgan, R., Hooiveld, M.H.W. and Durston, A.J. A novel guanine exchange factor increases the competence of early ectoderm to respond to neural induction. Mech.of Dev. 88:67-72, 1999.

Morgan, R., Hooiveld, M.H.W., In Der Rieden, P. and Durston, A.J. A conserved 30 base pair element in the Wnt-5a promoter is sufficient both to drive its' early embryonic expression and to mediate its' repression by otx2. Mech.of Dev. 85:97-102, 1999.

Morgan, R., Hooiveld, M.H.W., Pannese, M., Dati, G., Broders, F., Delarue, M., Thiery, J.-P., Boncinelli, E. and Durston, A.J. Calponin modulates the exclusion of otx-expressing cells from convergent extension movements. Nature Cell Biol. 1:404-408, 1999.

Mummery, C.L. and Van Den Eijnden-Van Raaij, A.J.M. Developmental tumours, early differentiation and the transforming growth factor b superfamily. Int.J.Dev.Biol. 43:693-709, 1999.

Nieuwkoop, P.D. (ed. by Gordon, R. and Björklund, N.K.) The neural induction process; its morphogenetic aspects. Int.J.Dev.Biol. 43:615-623, 1999.

Pap, E.H.W., Drummen, G.P.C., Winter, V.J., Kooij, T.W.A., Rijken, P., Wirtz, K.W.A., Op Den Kamp, J.A.F., Hage, W.J. and Post, J.A. Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY581/591. FEBS letters 453:278-282, 1999.

Richardson, M.K. and Narraway, J. A treasure house of comparative embryology. Int.J.Dev.Biol. 43:591-602, 1999.

Roshani, H., Dabhoiwala, N.F., Verbeek, F.J., Kurth, K.H. and Lamers, W.H. Anatomy of ureterovesical junction and distal ureter studied by endoluminal ultrasonography in vitro. J.Urol. 161:1614-1619, 1999.

Sonneveld, E. Retinoic acid metabolism: cause or consequence of RA action? A dual role for cytochrome P450 retinoic acid hydroxylase CYP26, Thesis, Univ. Utrecht, 1999. pp. 1-134.

Sonneveld, E., Van Den Brink, C.E., Tertoolen, L.G.J., Van Der Burg, B. and Van Der Saag, P.T. Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells. Dev.Biol. 213:390-404, 1999. 

Sonneveld, E., Van Den Brink, C.E., Van Der Leede, B.-J.M., Maden, M. and Van Der Saag, P.T. Embryonal carcinoma cell lines stably transfected with mRARb2-LACZ: sensitive system for measuring levels of active retinoids. Exp.Cell Res. 250:284-297, 1999.

Teicher, V.B., Kucharski, N., Martin, H.-D., Van Der Saag, P.T., Sies, H. and Stahl, W. Biological activities of Apo-canthaxanthinoic acids related to gap junctional communication. Arch.Biochem.Biophys. 365:150-155, 1999.

Ten Berge, D. Genetic regulation of skeletal development in the mouse; role of aristaless-related homeobox genes, Thesis, Univ. Utrecht, 1999. pp. 1-104.

Thorsteinsdöttir, S., Roelen, B.A.J., Goumans, M.-J., Ward-Van Oostwaard, D., Gaspar, A.C. and Mummery, C.L. Expression of the a6A integrin splice variant in developing mouse embryonic stem cell aggregates and correlation with cardiac muscle differentiation. Differentiation 64:173-184, 1999.

Van Den Akker, E., Reijnen, M., Korving, J., Brouwer, A., Meijlink, F. and Deschamps, J. Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. Mech.of Dev. 89:103-114, 1999.

Van Den Brink, G.R., Bloemers, S.M., Van Den Blink, B., Tertoolen, L.G.J., Van Deventer, S.J.H. and Peppelenbosch, M.P. Study of calcium signaling in non-excitable cells. Microsc.Res.Techn. 46:418-433, 1999.

Van Der Burg, B., Sonneveld, E., Lemmen, J.G. and Van Der Saag, P.T. Morphogenetic action of retinoids and estrogens. Int.J.Dev.Biol. 43:735-743, 1999.

Van Der Sar, A.M., De Fockert, J., Betist, M., Zivkovic, D. and Den Hertog, J. Pleiotropic effects of zebrafish protein-tyrosine phosphatase-1B on early embryonic development. Int.J.Dev.Biol. 43:785-794, 1999.

Van Eijk, M.J.T., Van Rooijen, M.A., Modina, S., Scesi, L., Folkers, G., Van Tol, H.T.A., Bevers, M.M., Fisher, S.R., Lewin, H.A., Rakacolli, D., Galli, C., De Vaureix, C., Trounson, A.O., Mummery, C.L. and Gandolfi, F. Molecular cloning, genetic mapping and developmental expression of bovine POU5F1. Biol.Reprod. 60:1093-1103, 1999.

Van Es, J.H., Kirkpatrick, C., Van De Wetering, M., Molenaar, M., Miles, A., Kuipers, J., Destrée, O.H.J., Peifer, M. and Clevers, H. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr.Biol. 9:105-108, 1999.

Van Pelt, A.M.M., De Rooij, D.G., Van Der Burg, B., Van Der Saag, P.T., Gustafsson, J.-Å. and Kuiper, G.G.J.M. Ontogeny of estrogen receptor b expression in rat testis. Endocrinology 140:478-483, 1999.

Van Puijenbroek, A.A.F.L., Van Der Saag, P.T. and Coffer, P.J. Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-Erk signaling. Exp.Cell Res. 251:465-476, 1999.

Van Puijenbroek, A.A.F.L., Wissink, S., Van Der Saag, P.T. and Peppelenbosch, M.P. Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block TNF-induced NF-kB activation. Cytokine 11:104-110, 1999.

Van Raaij, E.J., Boon, P.J., Maintz, J.B.A. and Verbeek, F.J. Composition of high resolution image mosaics for 3D reconstructions from serial sections in microscopy. In: Proceedings of the International Workshop on Biomedical Image Registration, edited by Kovacic, S., Pernus, F., Stiehl, H.S. and Viergever, M.A. 1999. Bled, Slovenia, August 1999. pp. 262-271, 1999.

Van Schothorst, E.M., Mohkamsing, S., Van Gurp, R.J.H.L.M., Oosterhuis, J.W., Van Der Saag, P.T. and Looijenga, L.H.J. Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines. Brit.J.Cancer 80:1571-1574, 1999.

Van Tilborg, P.J.A., Mulder, F.A.A., De Backer, M.M.E., Nair, M., Van Heerde, E.C., Folkers, G., Van Der Saag, P.T., Karimi-Nejad, Y., Boelens, R. and Kaptein, R. Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation. Biochemistry 38:1951-1956, 1999.

Veenstra, G.J.C., Destrée, O.H.J. and Wolffe, A.P. Translation of maternal TATA-binding protein mRNA potentiates basal but not activated transcription in Xenopus embryos at the midblastula transition. Mol.Cell.Biol. 19:7972-7982, 1999.

Veenstra, G.J.C., Mathu, M.T. and Destrée, O.H.J. The Oct-1 POU domain directs developmentally regulated nuclear translocation in Xenopus embryos. Biol.Chem. 380:253-257, 1999.

Verbeek, F.J., Lawson, K.A. and Bard, J.B.L. Developmental bioinformatics: linking genetic data to virtual embryos. Int.J.Dev.Biol. 43:761-771, 1999.

Verheijen, M.H.G. and Defize, L.H.K. Signals governing extraembryonic endoderm formation in the mouse: involvement of the type 1 parathyroid hormone-related peptide (PTHrP) receptor, p21Ras and cell adhesion molecules. Int.J.Dev.Biol. 43:711-721, 1999.

Verheijen, M.H.G., Karperien, M., Chung, U-i., Van Wijnen, M., Heystek, H., Hendriks, J.A.A., Veltmaat, J.M., Lanske, B., Li, E., Löwik, C.W.G.M., De Laat, S.W., Kronenberg, H.M. and Defize, L.H.K. Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the type I PTH/PTHrP receptor. Mech.of Dev. 81:151-161, 1999.

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