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Hubrecht publications

1991   1992   1993   1994   1995


1995
Beumer, T.L., Veenstra, G.J.C., Hage, W.J. and Destrée, O.H.J. Whole-mount immunohistochemistry on Xenopus embryos using far-red fluorescent dyes. Trends in Genet. 11:9, 1995.

Burgering, B.M.T. and Coffer, P.J. Protein kinase B (c-akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602, 1995.

Caldenhoven, E., Liden, J., Wissink, S., Van De Stolpe, A., Raaijmakers, J., Koenderman, L., Okret, S., Gustafsson, J.-Å. and Van Der Saag, P.T. Negative cross-talk between ReIA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol.Endocrinol. 9:401-412, 1995.

Charité, J., De Graaff, W., and Deschamps, J. Specification of multiple vertebral identities by ectopically expressed Hopxb-8. Dev. Dyn. 204:13-21, 1995.

Charité, J., De Graaff, W., Vogels, R., Meijlink, F. and Deschamps, J. Regulation of the Hoxb-8 gene: Synergism between multimerized cis-acting elements increases responsiveness to positional information. Dev.Biol. 171:294-305, 1995.

Chen, L., Wu, L., Otaka, A., Smyth, M.S., Roller, P.P., Burke (Jr), T.R., Den Hertog, J. and Zhang, Z.-Y. Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases? Biochem.Biophys.Res.Comm. 216:976-984, 1995.

Coffer, P.J. Burgering, B.M.T., Peppelenbosch, M.P., Bos, J.L. and Kruijer, W. UV activation of receptor tyrosine kinase activity. Oncogene 11:561-569, 1995.

Coffer, P.J. and Kruijer, W. EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem.Biophys.Res.Comm. 210:74-81, 1995.

Coffer, P.J., Lütticken, C., Van Puijenbroek, A., Klop-De Jonge, M., Horn, F. and Kruijer, W. Transcriptional regulation of the junb promoter: analysis of STAT-mediated signal transduction. Oncogene 10:985-994, 1995.

De Groot, R.P., Kranenburg, O., De Wit, L., Van Den Eijnden-Van Raaij, A.J.M., Mummery, C.L., Van Der Eb, A.J. and Zantema, A. Adenovirus E1A antagonizes both negative and positive growth signals elicited by TGFb1. Cell Growth and Diff. 6:531-540, 1995.

De Wit, I.S.C. Phosphatidylinositol transfer protein during development, growth and differentiation, Thesis, Univ. Utrecht, 1995. pp.1-104.

De Wit, I.S.C., De Laat, S.W., Snoek, G.T. and Wirtz, K.W.A. Phosphatidylinositol transfer protein in murine embryonal carcinoma cells during retinoic acid-induced differentiation. Dev.Growth & Diff. 37:99-109, 1995.

Den Hertog, J., Sap, J., Pals, C.E.G.M., Schlessinger, J. and Kruijer, W. Stimulation of receptor protein-tyrosine phosphatase a activity and phosphorylation by phorbol ester. Cell Growth and Diff. 6:303-307, 1995.

Destrée, O.H.J. Nobelprijs voor geneeskunde/fysiologie 1995. Ned.Tijdschr.v.Geneesk. 139:2711-2713, 1995.

Destrée, O.H.J. Wnt-signaal-glycoproteïnen, regulatoren van embryonale groei en differentiatie. Tijdschr. Kindergeneesk. 63, suppl.2:9-14, 1995.

Durston, A.J., Van Der Wees, J., Pijnappel, W.W.M., Schilthuis, J.G. and Godsave, S.F. Retinoids and axial patterning in the early vertebrate embryo. In: Organization of the Early Vertebrate Embryo, edited by Zagris, N., Duprat, A.M. and Durston, A.J. New York etc.: Plenum Press, 1995. Proc. NATO Adv. Study Inst., Spetsai, Greece, Sept. 1994. NATO ASI Series, Series A: Life Scis, 279:249-261, 1995.

Eizema, K. Regulation of the engrailed-1 gene in early development of Xenopus laevis, Thesis, Univ.Utrecht, 1995. pp. 1-141.

Folkers, G.E. and Van Der Saag, P.T. Adenovirus E1A functions as a cofactor for retinoic acid receptor b (RARb) through direct interaction with RARb. Mol.Cell.Biol. 15:5868-5878, 1995.

Folkers, G.E., Van Heerde, E.C. and Van Der Saag, P.T. Activation function 1 of retinoic acid receptor b2 is an acidic activator resembling VP16. J.Biol.Chem. 270:23552-23559, 1995.

Gutknecht, D.R., Koster, C.H., Tertoolen, L.G.J., De Laat, S.W. and Durston, A.J. Intracellular acidification of gastrula ectoderm is important for posterior axial development in Xenopus. Development 121:1911-1925, 1995.

Hofland, L.J., Van Der Burg, B., Van Eijck, C.H.J., Sprij, D.M., Van Koetsveld, P.M. and Lamberts, S.W.J. Role of tumor-derived fibroblasts in the growth of primary cultures of human breast-cancer cells: effects of epidermal growth factor and the somatostatin analogue octreotide. Int.J.Cancer 60:93-99, 1995.

Jahnke, A., Van De Stolpe, A., Caldenhoven, E. and Johnson, J.P. Constitutive expression of human intercellular adhesion molecule-1 (ICAM-1) is regulated by differentially active enhancing and silencing elements. Europ.J.Biochem. 228:439-446, 1995.

Joore, J. Embryonic axis formation in zebrafish; regulation of goosecoid expression, Thesis, Univ.Utrecht, 1995. pp. 1-188.

Kalkhoven, E. Progestin action in human breast tumor cells, Thesis, Univ. Utrecht, 1995. pp. 1-126.

Kalkhoven, E., Kwakkenbos-Isbrücker, L., Mummery, C.L., De Laat, S.W., Van Den Eijnden-Van Raaij, A.J.M., Van Der Saag, P.T. and Van Der Burg, B. The role of TGF-b production in growth inhibition of breast-tumor cells by progestins. Int.J.Cancer 61:80-86, 1995.

Kalkhoven, E., Roelen, B.A.J., De Winter, J.P., Mummery, C.L., Van Den Eijnden-Van Raaij, A.J.M., Van Der Saag, P.T. and Van Der Burg, B. Resistance to transforming growth factor b and activin due to reduced receptor expression in human breast tumor cell lines. Cell Growth Diff. 6:1151-1161, 1995.

Karperien, M. Parathyroid hormone related peptide and its receptor in mouse embryonic development, Thesis, Univ. Utrecht, 1995. pp. 1-200.

Kooistra, A., Van Den Eijnden-Van Raaij, A.J.M., Klaij, I.A., Romijn, J.C. and Schröder, F.H. Stromal inhibition of prostatic epithelial cell proliferation not mediated by transforming growth factor beta. Brit.J.Cancer 72:427-434, 1995.

Leussink, B., Brouwer, A., El Khattabi, M., Poelmann, R.E., Gittenberger-De Groot, A.C. and Meijlink, F. Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain. Mech.of Dev. 52:51-64, 1995.

Lütticken, C., Coffer, P., Yuan, J., Schwartz, C., Caldenhoven, E., Schindler, C., Kruijer, W., Heinrich, P.C. and Horn, F. Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Febs Lett. 360:137-143, 1995.

Nieuwkoop, P.D. The successive morphogenetic interactions leading to neural crest formation; inductive actions and competences. In: Embryos, Endocrine Cells and the Neural Crest; a Collection of Essays in Honour of Ann Andrew, edited by Kramer, B. and Rawdon, B. Witwatersrand: Univ. Press, 1995, p. 117-123.

Nieuwkoop, P.D. and Koster, K. Vertical versus planar induction in amphibian early development. Dev.,Growth & Diff. 37:653-668, 1995.

Nikawa, T., Schulz, W.A., Van Den Brink, C.E., Hanusch, M., Van Der Saag, P.T., Stahl, W. and Sies, H. Efficacy of all-trans-b-carotene, canthaxanthin, and all-trans-, 9-cis-, and 4-oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RARb-lacZ reporter cell line. Arch.Biochem.Biophys. 316:665-672, 1995 

Peppelenbosch, M.P., Qiu, R.-G., De Vries-Smits, A.M.M., Tertoolen, L.G.J., De Laat, S.W., McCormick, F., Hall, A., Symons, M.H. and Bos, J.L. Rac mediates growth factor-induced arachidonic acid release. Cell 81:849-856, 1995.

Peppelenbosch, M.P., Tertoolen, L.G.J., De Laat, S.W. and Zivkovic, D. Ionic responses to epidermal growth factor in zebrafish cells. Exp.Cell Res. 218:183-188, 1995.

Peppelenbosch, M.P., Tertoolen, L.G.J., Van Der Flier, A. and De Laat, S.W. Evaluation of single-channel gating kinetics produced after amplitude-based separation of unitary currents. J.Neurosci.Methods 58:49-59, 1995.

Pijnappel, W.W.M. Active retinoids in Xenopus development, Thesis, Univ.Utrecht, 1995. pp. 1-127.

Rijken, P.J., Post, S.M., Hage, W.J., Van Bergen en Henegouwen, P.M.P., Verkleij, A.J. and Boonstra, J. Actin polymerization localizes to the activated epidermal growth factor receptor in the plasma membrane, independent of the cytosolic free calcium transient. Exp.Cell Res. 218:223-232, 1995.

Schalkwijk, C.G., Spaargaren, M., Defize, L.H.K., Verkleij, A.J., Van Den Bosch, H. and Boonstra, J. Epidermal growth factor (EGF) induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic phospholipase A2. Europ.J.Biochem. 231:593-601, 1995.

Schoorlemmer, J., Jonk, L., Shen, S., Van Puijenbroek, A., Feijen, A. and Kruijer, W. Regulation of Oct-4 gene expression during differentiation of EC cells. Mol.Biol.Rep. 21:129-140, 1995.  

Schootemeijer, A., Gorter, G., Tertoolen, L.G.J., De Laat, S.W. and Akkerman, J.-W.N. Relation between membrane fluidity and signal transduction in the human megakaryoblastic cell line MEG-01. Biochim.Biophys.Acta 1236:128-134, 1995.

Spaargaren, M., De Laat, S.W. and Boonstra, J. General mechanistic patterns of signal transduction across membranes. In: Signal Transduction across Membranes, edited by Shinitzky, M. Weinheim etc: VCH Publ., 1995. Handbook of Biomembranes 3:1-59, 1995.

Thorsteinsdóttir, S. Laminins and the a6b1 integrin in mouse embryonic development, Thesis, Univ.Utrecht, 1995. pp. 1-148.

Thorsteinsdóttir, S., Roelen, B.A.J., Freund, E., Gaspar, A.C., Sonnenberg, A. and Mummery, C.L. Expression patterns of laminin receptor splice variants a6Ab1 and a6Bb1 suggest different roles in mouse development. Dev. Dyn. 204:240-258, 1995.

Ubbels, G.A., Reijnen, M., Meijerink, J. and Narraway, J.  The role of gravity in the establishment of the dorso-ventral axis in the amphibian embryo. In: Biorack on Space Lab.IML-1, edited by Mattok, C. Noordwijk: ESA Publ., 1995, p. 175-185.

Vahlenkamp, T.W., De Ronde, A., Balzarini, J., Naesens, L., De Clercq, E., Van Eijk, M.J.T., Horzinek, M.C. and Egberink, H.F. (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection. Antimicrob. Agents Chemoter. 39:746-749, 1995.

Vahlenkamp, T.W., Egberink, H.F., Van Eijk, M.J.T., Slotboom-Kamphorst, A.M.E., Verschoor, E.J., Horzinek, M.C. and De Ronde, A. Competitive reverse transcription-polymerase chain reaction for quantitation of feline immunodeficiency virus. J.Virol.Meth. 52:335-346, 1995.

Van De Stolpe, A. Intercellular adhesion molecule-1; expression regulation and fibrinogen binding, Thesis, Univ.Utrecht, 1995. pp. 1-134.

Van Den Berg, C., Willemsen, V., Hage, W., Weisbeek, P. and Scheres, B. Cell fate in the Arabidopsis root meristem determined by directional signalling. Nature 378:62-65, 1995.

Van Der Bruggen, T., Caldenhoven, E., Kanters, D., Coffer, P., Raaijmakers, J.A.M., Lammers, J.-W.J. and Koenderman, L. Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1a. Blood 85:1442-1448, 1995.

Van Der Burg, B., Slager-Davidov, R., Van Der Leede, B.-j.M., De Laat, S.W. and Van Der Saag, P.T. Differential regulation of AP1 activity by retinoic acid in hormone-dependent and -independent breast cancer cells. Mol.Cell.Endocrinol. 112:143-152, 1995.

Van Der Kruijssen, C.M.M., Van Achterberg, T.A.E., Feijen, A., Hébert, J.M., De Waele, P. and Van Den Eijnden-Van Raaij, A.J.M. Neuronal and mesodermal differentiation of P19 embryonal carcinoma cells is characterized by expression of specific marker genes and modulated by activin and fibroblast growth factors. Dev.,Growth & Diff. 37:559-574, 1995.

Van Der Leede, B.-J.M., Folkers, G.E., Van Den Brink, C.E., Van Der Saag, P.T. and Van Der Burg, B. Retinoic acid receptor a1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells. Mol.Cell.Endocrinol. 109:77-86, 1995.

Van Der Leede, B.-J.M., Opdenoordt, T., Van Den Brink, C.E., Ebert, T. and Van Der Saag, P.T. Implication of retinoic acid receptor b in renal cell carcinoma. Int.J.Oncol. 6:391-400, 1995.

Van Inzen, W.G., Van Stekelenburg-Hamers, A.E.P., Weima, S.M., Kruip, T.A.M., Bevers, M.M. and Mummery, C.L. Culture of bovine embryos to the blastocyst stage using buffalo rat liver (BRL) cells. Theriogenology 43:723-738, 1995.

Van Stekelenburg-Hamers, A.E.P., Van Achterberg, T.A.E., Rebel, H.G., Fléchon, J.E., Campbell, K.H.S., Weima, S.M. and Mummery, C.L. Isolation and characterization of permanent cell lines from inner cell mass cells of bovine blastocysts. Mol.Reprod.Dev. 40:444-454, 1995.

Van Weering, D.H.J., Medema, J.P., Van Puijenbroek, A., Burgering, B.M.T., Baas, P.D. and Bos, J.L. Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells. Oncogene 11:2207-2214, 1995.

Veenstra, G.J.C., Beumer, T.L., Peterson-Maduro, J., Stegeman, B.I., Karg, H.A., Van Der Vliet, P.C. and Destrée, O.H.J. Dynamic and differential Oct-1 expression during early Xenopus embryogenesis: persistence of Oct-1 protein following down-regulation of the RNA. Mech.of Dev. 50:103-117, 1995.

Verheijen, M.H.G. and Defize, L.H.K. Parathyroid hormone inhibits mitogen-activated protein kinase activation in osteosarcoma cells via a protein kinase A-dependent pathway. Endocrinology 136:3331-3337, 1995.

Verschueren, K., Dewulf, N., Goumans, M.-J., Lonnoy, O., Feijen, A., Grimsby, S., Vande Spiegle, K., Ten Dijke, P., Morén, A., Vanscheeuwijck, P., Heldin, C.-H., Miyazono, K., Mummery, C., Van Den Eijnden-Van Raaij, J. and Huylebroeck, D. Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech.of Dev. 52:109-123, 1995.

Zagris, N., Duprat, A.M., and Durston, A. (Eds) Organization of the Early Vertebrate Embryo. New York etc., Plenum Press, 1995. Proc. NATO Adv. Study Inst., Spetsai, Greece, Sept. 1994. NATO ASI Series, Series A: Life Scis, 279:VIII,1-336, 1995.



1994

Ameerun, R. Zes minuten in de ruimte. Mens en Wetenschap 21:122-123, 1994.

Caldenhoven, E., Coffer, P., Yuan, J., Van De Stolpe, A., Horn, F., Kruijer, W. and Van Der Saag, P.T. Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-g? involves binding of distinct factors to a palindromic response element. J.Biol.Chem. 269:21146-21154, 1994.

Charité, J. Regulation and function of murine Hox genes. Thesis, Univ.Utrecht, pp. 1-104, 1994.

Charité, J., De Graaff, W., Shen, S. and Deschamps, J. Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell 78:589-601, 1994.

Coffer, P.J. and Woodgett, J.R. Differential subcellular localisation of two isoforms of p70 S6 protein kinase. Biochem.Biophys.Res.Comm. 198:780-786, 1994.

Coffer, P.J., De Jonge, M., Mettouchi, A., Binetruy, B., Ghysdael, J. and Kruijer, W. Junb promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2. Oncogene 9:911-921, 1994.

De Boer, W.I., Rebel, J.M.J., Thijssen, C.D.E.M., Vermeij, M., Van Den Eijnden-Van Raaij, A.J.M. and Van Der Kwast, T.H. Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways. Virch.Arch. 425:439-444, 1994.

De Rooij, D.G., Van Pelt, A.M.M., Van De Kant, H.J.G., Van Der Saag, P.T., Peters, A.H.F.M., Heyting, C. and De Boer, P. Role of retinoids in spermatogonial proliferation and differentiation and the meiotic prophase. In: Function of Somatic Cells in the Testis, edited by Bartke, A. New York etc.: Springer, 1994, p. 345-361.

Dekker, E.-J., Vaessen, M.-J., Van Den Berg, C., Timmermans, A., Godsave, S., Holling, T., Nieuwkoop, P.D., Geurts van Kessel, A. and Durston, A.J. Overexpression of a cellular retinoic acid binding protein (xCRABP) causes anteroposterior defects in developing Xenopus embryos. Development 120:973-985, 1994.

Destrée, O.H.J., Gao, X. and Koster, J.G. Wnt-genen: mediatoren van embryonale groei en differentiatie. In: Nascholing Kindergeneeskunde, edited by Van Gool, J.D. and Versluys, C. Utrecht: Wilhelmina Kinderziekenhuis, 1994, p. 1-15.

Eizema, K., Koster, J.G., Stegeman, B.I., Baarends, W.M., Lanser, P.H. and Destrée, O.H.J. Comparative analysis of Engrailed-1 and Wnt-1 expression in the developing central nervous system of Xenopus laevis. Int.J.Dev.Biol. 38:623-632, 1994.

Feijen, A., Goumans, M.J. and Van Den Eijnden-Van Raaij, A.J.M. Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development 120:3621-3637, 1994.

Gao, X., Kalkhoven, E., Peterson-Maduro, J., Van Der Burg, B. and Destrée, O.H.J. Expression of the glucocorticoid receptor gene is regulated during early embryogenesis of Xenopus laevis. Biochim.Biophys.Acta 1218:194-198, 1994.

Gao, X., Stegeman, B.I., Lanser, P., Koster, J.G. and Destrée, O.H.J. GR transcripts are localized during early Xenopus laevis embryogenesis and overexpression of GR inhibits differentiation after dexamethasone treatment. Biochem.Biophys.Res.Comm. 199:734-741, 1994.

Gao, X., Kuiken, G.A., Baarends, W.M., Koster, J.G. and Destrée, O.H.J. Characterization of a functional promoter for the Xenopus Wnt-1 gene in vivo. Oncogene 9:573-581, 1994.

Gao, X. Transcriptional regulation of the Wnt-1 gene and functional analysis of the glucocorticoid receptor in early embryogenesis of Xenopus laevis. Thesis, Univ. Utrecht, pp. 1-92, 1994.

Godsave, S., Dekker, E.-J., Holling, T., Pannese, M., Boncinelli, E. and Durston, A.J. Expression patterns of Hoxb genes in the Xenopus embryo suggest roles in anteroposterior specification of the hindbrain and in dorsoventral patterning of the mesoderm. Dev.Biol. 166:465-476, 1994.

Gordon, R., Björklund, N.K. and Nieuwkoop, P.D. Appendix: Dialogue on embryonic induction and differentiation waves. Int. Rev. Cytol. 150:373-420, 1994.

Jonk, L.J.C., De Jonge, M.E.J., Pals, C.E.G.M., Wissink, S., Vervaart, J.M.A., Schoorlemmer, J. and Kruijer, W. Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors. Mech.of Dev. 47:81-97, 1994.

Jonk, L.J.C., De Jonge, M.E.J., Vervaart, J.M.A., Wissink, S. and Kruijer, W. Isolation and developmental expression of retinoic-acid-induced genes. Dev.Biol. 161:604-614, 1994.

Joore, J., Van Der Lans, G.B.L.J., Lanser, P.H., Vervaart, J.M.A., Zivkovic, D., Speksnijder, J.E. and Kruijer, W. Effects of retinoic acid on the expression of retinoic acid receptors during zebrafish embryogenesis. Mech.of Dev. 46:137-150, 1994.

Kalkhoven, E., Kwakkenbos-Isbrücker, L., De Laat, S.W., Van Der Saag, P.T. and Van Der Burg, B. Synthetic progestins induce proliferation of breast tumor cell lines via the progesterone or estrogen receptor. Mol.Cell.Endocrinol. 102:45-52, 1994.

Karperien, M., Van Dijk, T.B., Hoeijmakers, T., Cremers, F., Abou-Samra, A.-B., Boonstra, J., De Laat, S.W. and Defize, L.H.K. Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes. Mech.of Dev. 47:29-42, 1994.

Kong, X.-F., Schipani, E., Lanske, B., Joun, H., Karperien, M., Defize, L.H.K., Jüppner, H., Potts, J.T.(Jr.), Segre, G.V., Kronenberg, H.M. and Abou-Samra, A.-B. The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem.Biophys.Res.Comm. 200:1290-1299, 1994.

Kuiken, G.A., Bertens, P.J.A., Peterson-Maduro, J., Veenstra, G.J.C., Koster, J.G. and Destrée, O.H.J. The promoter of the Xwnt-5C gene contains octamer and AP-2 motifs functional in Xenopus embryos. Nucl.Acids Res. 22:1675-1680, 1994.

Lawson, K.A. and Hage, W.J. Clonal analysis of the origin of primordial germ cells in the mouse. In: Germline Development, edited by Marsh, J. and Goode, J. Chichester: Wiley, 1994, p. 68-91. Symp. London, July 1993; CIBA Found. Symp. 182.

Lin, H.Y. Hot papers/Cell Biology: Expression cloning of the TGF-b type II receptor, a functional transmembrane serine/threonine kinase by H.Y.Lin et al/in: Cell, 1992, 68, 775-785. The Scientist 8:16, 1994.

Paulusma, C.C., Van Der Kruijssen, C.M.M. and Van Den Eijnden-Van Raaij, A.J.M. Localization of activin subunits in early murine development determined by subunit-specific antibodies. J.Immunol.Meth. 169:143-152, 1994.

Peppelenbosch, M.P. and Tertoolen, L.G.H. Action and function of receptor protein tyrosine kinases; the role of arachidonic acid metabolites and tyrosine phosphatases. Thesis, Univ. Utrecht, pp. 1-316, 1994.

Rijken, P.J., Boonstra, J., Verkleij, A.J. and De Laat, S.W. Effects of gravity on the cellular response to epidermal growth factor. Adv.Space Biol.Med. 4:159-188, 1994.

Roelen, B.A.J., Lin, H.Y., Knezevic, V., Freund, E.C.A. and Mummery, C.L. Expression of TGF-bs and their receptors during implantation and organogenesis of the mouse embryo. Dev.Biol. 166:716-728, 1994.

Schoorlemmer, J., Van Puijenbroek, A., Van Den Eijnden, M., Jonk, L., Pals, C. and Kruijer, W. Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Mol.Cell.Biol. 14:1122-1136, 1994.

Schootemeijer, A., Van Beekhuizen, A.E., Gorter, G., Tertoolen, L.G.J., De Laat, S.W. and Akkerman, J.-W.N. Rapid alterations in lateral mobility of lipids in the plasma membrane of activated human megakaryocytes. Europ.J.Biochem. 221:353-362, 1994.

Schootemeijer, A., Van Beekhuizen, A.E., Tertoolen, L.G.J., De Laat, S.W. and Akkerman, J.-W.N. Cytosolic calcium ions regulate lipid mobility in the plasma membrane of the human megakaryoblastic cell line MEG-01. Europ.J.Biochem. 224:423-430, 1994.

Ubbels, G.A., Reijnen, M., Meijerink, J. and Narraway, J. Xenopus laevis embryos can establish their spatial bilateral symmetrical body pattern without gravity. Adv.Space Res. 14:257-269, 1994.

Ubbels, G.A., Reijnen, M., Meijerink, J. and Narraway, J. "EGGS"-The role of gravity in the establishment of the dorso-ventral axis in the amphibian embryo. In: First Intern. Microgravity Lab., Review of Science Results, Life Sciences Investigations, vol.1, 1994, p. 109-118.

Van De Stolpe, A., Caldenhoven, E., Stade, B.G., Koenderman, L., Raaijmakers, J.A.M., Johnson, J.P. and Van Der Saag, P.T. 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor a-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. J.Biol.Chem. 269:6185-6192, 1994.

Van Den Eijnden-Van Raaij, A.J.M., Goumans, M.-J. and Feijen, A. Follistatins, activins and activin receptors in mouse development. In: Proc. 8th Intern. Conf. Intern. Soc. Diff. Hiroshima, Japan: Org.Committee Conf., 1994, p. 124-127. Conf. Hiroshima, Japan, October 1994.

Van Der Leede, B.-J.M. Tumor suppressor activity of retinoic acid receptors. Thesis, Univ. Utrecht, pp. 1-136, 1994.

Van Der Lugt, N.M.T., Domen, J., Linders, K., Van Roon, M., Robanus-Maandag, E., Te Riele, H., Van Der Valk, M., Deschamps, J., Sofroniew, M., Van Lohuizen, M. and Berns, A. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes and Dev. 8:757-769, 1994.

Van Stekelenburg-Hamers, A.E.P., Rebel, H.G., Van Inzen, W.G., De Loos, F.A.M., Drost, M., Mummery, C.L., Weima, S.M. and Trounson, A.O. Stage-specific appearance of the mouse antigen TEC-3 in normal and nuclear transfer bovine embryos: re-expression after nuclear transfer. Mol.Reprod.Dev. 37:27-33, 1994.

Van Stekelenburg-Hamers, A.E.P. Developmental potency in early bovine embryos. Thesis, Univ. Utrecht, pp. 1-156, 1994.

Wurth, Y.A. Bovine embryo production in vitro; influencing factors. Thesis, Univ. Utrecht, pp. 1-140, 1994.

1993
Ameerun, R. Hoe ontwikkelt zich een embryo? BioNieuws 3:5, 1993.

Bloemers, S.M. Function and expression of the histamine H1-receptor in the early development of the mouse. Thesis, Univ. Utrecht, pp. 1-144, 1993.

Bloemers, S.M., Leurs, R., Smit, M.J., Verheule, S., Tertoolen, L.G.J., Timmerman, H. and De Laat, S.W. Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors. Biochem.Biophys.Res.Comm. 191:118-125, 1993.

Burgering, B.M.T., De Vries-Smits, A.M.M., Medema, R.H., Van Weeren, P.C., Tertoolen, L.G.J. and Bos, J.L. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol. Cell. Biol. 13:7248-7256, 1993.

De Groot, R.P., Den Hertog, J., Vandenheede, J.R., Goris, J. and Sassone-Corsi, P. Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J. 12,10:3903-3911, 1993.

De Jong, F.H., De Winter, J.P., Wesseling, J.G., Timmerman, M.A., Van Genesen, S., Van Den Eijnden-Van Raaij, A.J.M. and Van Zoelen, E.J.J. Inhibin subunits, follistatin and activin receptors in the human teratocarcinoma cell line Tera-2. Biochem.Biophys.Res.Comm. 192:1334-1339, 1993.

De Jong, R. Expression and function of murine homeodomain proteins. Thesis, Univ. Utrecht, pp. 1-116, 1993.

De Jong, R. and Meijlink, F. The homeobox gene S8: mesoderm-specific expression in presomite embryos and in cells cultured in vitro, and modulation in differentiating pluripotent cells. Dev.Biol. 157:133-146, 1993.

De Jong, R., Van Der Heijden, J. and Meijlink, F. DNA-binding specificity of the S8 homeodomain. Nucl.Acids Res. 21:4711-4720, 1993.

Dekker, E.-J., Pannese, M., Houtzager, E., Boncinelli, E. and Durston, A.J. Colinearity in the Xenopus laevis Hox-2 complex. Mech.of Dev. 40:3-12, 1993.

Dekker, E.-J. Regulation of early Xenopus pattern formation by retinoid signalling. Thesis, Univ. Utrecht, pp. 1-156, 1993.

Den Hertog, J., Pals, C.E.G.M., Peppelenbosch, M.P., Tertoolen, L.G.H., De Laat, S.W. and Kruijer, W. Receptor protein  tyrosine phosphatase a activates pp60c-src and is involved in neuronal differentiation. EMBO J. 12,10:3789-3798, 1993.

Deschamps, J.T. and Wijgerde, M. Two phases in the establishment of Hox expression domains. Dev.Biol. 156:473-480, 1993.

Dickson, M.C., Slager, H.G., Duffie, E., Mummery, C.L. and Akhurst, R.J. RNA and protein localisations of TGFb2 in the early mouse embryo suggest an involvement in cardiac development. Development 117:625-639, 1993.

Folkers, G.E., Van Der Leede, B.-J.M. and Van Der Saag, P.T. The retinoic acid receptor-b2 contains two separate cell-specific transactivation domains, at the N-terminus and in the ligand-binding domain. Mol.Endocrinol. 7:616-627, 1993.

Gao, X., Kalkhoven, E., Peterson-Maduro, J. and Destrée, O.H.J. Expression of the glucocorticoid receptor mRNA is regulated during early Xenopus laevis embryonic development. Ann.N.Y.Acad.Scis 684:205-206, 1993.

Heideveld, M. Molecular analysis of embryonic inductions. Thesis, Univ. Utrecht, pp. 1-64, 1993.

Heideveld, M., Ayoubi, T.A.Y., Van De Wiel, M.H.J., Martens, G.J.M. and Durston, A.J. Proopiomelanocortin gene expression as a neural marker during the embryonic development of Xenopus laevis. Differentiation 52:195-200, 1993.

Hierck, B.P., Thorsteinsdóttir, S., Niessen, C.M., Freund, E.C.A., Van Iperen, L., Feijen, A., Hogervorst, F., Poelmann, R.E., Mummery, C.L. and Sonnenberg, A. Variants of the a6b1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin a6 subunit. Cell Adh.Comm. 1:33-53, 1993.

Jonk, L.J.C. Isolation and developmental expression of retinoic acid regulated genes. Thesis, Univ. Utrecht, pp. 1-112, 1993.

Kalkhoven, E., Kwakkenbos-Isbrücker, L., De Laat, S.W. and Van Der Burg, B. Synthetic progestins in breast tumor cells; regulation of proliferation and receptor activation. Ann.N.Y.Acad.Scis 684:220-221, 1993.

Knegtel, R.M.A., Katahira, M., Schilthuis, J.G., Bonvin, A.M.J.J., Boelens, R., Eib, D., Van Der Saag, P.T. and Kaptein, R. The solution structure of the human retinoic acid receptor-b DNA-binding domain. J.Biomol.Nucl.Magn.Resonance 3:1-17, 1993.

Knegtel, R.M.A., Boelens, R., Ganadu, M.L., George, A.V.E., Katahira, M., Bonvin, A.M.J.J., Eib, D., Van Der Saag, P.T. and Kaptein, R. NMR studies of human retinoic acid receptor-b DNA-binding domain; metal coordination and three-dimensional structure. Ann.N.Y.Acad.Scis 684:49-62, 1993.

Knegtel, R.M.A., Boelens, R., Ganadu, M.L., George, A.V.E., Van der Saag, P.T and Kaptein, R. Heteronuclear 113Cd-1H NMR study of metal coordination in the human retinoic acid receptor-b DNA binding domain. Biochem.Biophys.Res.Comm. 192:492-498, 1993.

Kruyt, F.A.E., Folkers, G.E., Walhout, A.J.M., Van Der Leede, B.-J.M. and Van Der Saag, P.T. E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-b2 promoter activation. Mol.Endocrinol. 7:604-615, 1993.

Kuiken, G.A. Regulation of Wnt gene expression during the early development of Xenopus laevis. Thesis, Univ. Utrecht, pp. 1-110, 1993.

McDevitt, D.S., Brahma, S.K. and Jeanny, J.-C. Embryonic appearance of rod opsin in the urodele amphibian eye. Roux's Arch.Dev.Biol. 203:164-168, 1993.

McDevitt, D.S., Brahma, S.K., Jeanny, J.-C. and Hicks, D. Presence and foveal enrichment of rod opsin in the "all cone" retina of the American chameleon. Anat.Rec. 237:299-307, 1993.

Mummery, C.L. and Van Der Saag, P.T. Mediators of cell growth and differentiation. In: Developmental Biology and Cancer, edited by Hodges, G.M. and Rowlatt, C. Florida: Boca Raton, CRC Press, 1993, p.235-273.

Mummery, C.L. and Van Den Eijnden-Van Raaij, A.J.M. Type b transforming growth factors and activins in differentiating embryonal carcinoma cells, embryonic stem cells and early embryonic development. Int.J.Dev.Biol. 37:169-182, 1993.

Mummery, C.L., Van Rooijen, M.A., Bracke, M., Van Den Eijnden-Van Raaij, A.J.M., Van Zoelen, E.J.J. and Alitalo, K. Fibroblast growth factor-mediated growth regulation and receptor expression in embryonal carcinoma and embryonic stem cells and human germ cell tumours. Biochem.Biophys.Res.Comm. 191:188-195, 1993.

Mummery, C.L., Slager, H.G., Van Inzen, W.G., Freund, E.C.A. and Van Den Eijnden-Van Raaij, A.J.M. Regulation of growth and differentiation in early development: of mice and models. Reprod.Toxicol. 7:145-154, 1993.

Nieuwkoop, P.D. Vertical and planar induction in early amphibian development during meso-endoderm formation and neural plate development. Acta Biol.Exp.Sinica 26:307-315, 1993.

Nikolakaki, E., Coffer, P.J., Hemelsoet, R., Woodgett, J.R. and Defize, L.H.K. Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene 8:833-840, 1993.

Oosterwegel, M., Van De Wetering, M., Timmerman, M.A., Kruisbeek, A., Destrée, O.H.J., Meijlink, F. and Clevers, H. Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis. Development 118:439-448, 1993.

Peppelenbosch, M.P., Tertoolen, L.G.J., Hage, W.J. and De Laat, S.W. Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products. Cell 74:565-575, 1993.

Piersma, A.H., Roelen, B., Roest, P., Haakmat-Hoesenie, A.S., Van Achterberg, T.A.E. and Mummery, C.L. Cadmium-induced inhibition of proliferation and differentiation of embryonal carcinoma cells in culture and mechanistic aspects of protection by zinc. Teratology 48:335-341, 1993.

Pijnappel, W.W.M., Hendriks, H.F.J., Folkers, G.E., Van Den Brink, C.E., Dekker, E.-J., Edelenbosch, C., Van Der Saag, P.T. and Durston, A.J. The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification. Nature 366:340-344, 1993.

Rijken, P.J., De Groot, R.P., Van Belzen, N., De Laat, S.W., Boonstra, J. and Verkleij, A.J. Inhibition of EGF-induced signal transduction by microgravity is independent of EGF receptor redistribution in the plasma membrane of A431 cells. Exp.Cell Res. 204:373-377, 1993.

Schoorlemmer, J. Regulation of gene expression in embryonic stemm cells. Thesis, Univ. Utrecht, pp. 1-132, 1993.

Schootemeijer, A. Membrane dynamics and signal transduction in megakaryocytes. Thesis, Univ. Utrecht, pp. 1-136, 1993.

Shen, S. Regulation and function of the retinoic acid receptor b2 gene. Thesis, Univ. Utrecht, pp. 1-102, 1993.

Shen, S., Van Der Saag, P.T. and Kruijer, W. Dominant negative retinoic acid receptor b. Mech.of Dev. 40:177-189, 1993.

Slager, H.G., Van Inzen, W.G., Freund, E.C.A., Van Den Eijnden-Van Raaij, A.J.M. and Mummery, C.L. Transforming growth factor-b in the early mouse embryo: implications for the regulation of muscle formation and implantation. Dev.Gen. 14:212-224, 1993.

Slager, H.G., Freund, E.C.A., Buiting, A.M.J., Feijen, A. and Mummery, C.L. Secretion of transforming growth factor-b isoforms by embryonic stem cells: isoform and latency are dependent on direction of differentiation. J.Cell.Physiol. 156:247-256, 1993.

Smit, M.J., Leurs, R., Bloemers, S.M., Tertoolen, L.G.J., Bast, A., De Laat, S.W. and Timmerman, H. Extracellular ATP elevates cytoplasmic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor. Europ. J. Pharmacol. 247:223-226, 1993.

Speksnijder, J.E., Terasaki, M., Hage, W.J., Jaffe, L.F. and Sardet, C. Polarity and reorganization of the endoplasmic reticulum during fertilization and ooplasmic segregation in the ascidian egg. J.Cell Biol. 120:1337-1346, 1993.

Tilly, B.C., Van den Berghe, N., Tertoolen, L.G.J., Edixhoven, M.J. and De Jonge, H.R. Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances. J.Biol.Chem. 268,27:19919-19922, 1993.

Van De Stolpe, A., Caldenhoven, E., Raaijmakers, J.A.M., Van Der Saag, P.T. and Koenderman, L. Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am.J.Resp.Cell Mol.Biol. 8:340-347, 1993.

Van De Stolpe, A., Karperien, M., Löwik, C.W.G.M., Jüppner, H., Segre, G.V., Abdul-Badi Abou-Samra, De Laat, S.W. and Defize, L.H.K. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. J.Cell Biol. 120:235-243, 1993.

Van Delft, S., Coffer, P., Kruijer, W. and Van Wijk, R. C-fos induction by stress can be mediated by the SRE. Biochem.Biophys.Res.Comm. 197:542-548, 1993.

Van Der Burg, B., Van Der Leede, B.-J.M., Kwakkenbos-Isbrücker, L., Salverda, S., De Laat, S.W. and Van Der Saag, P.T. Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function. Mol.Cell.Endocrinol. 91:149-157, 1993.

Van Der Kruijssen, C.M.M., Feijen, A., Huylebroeck, D. and Van Den Eijnden-Van Raaij, A.J.M. Modulation of activin expression by type b transforming growth factors. Exp.Cell Res. 207:407-412, 1993.

Van Der Leede, B.-J.M., Van Den Brink, C.E. and Van Der Saag, P.T. Retinoic acid receptor and retinoid X receptor expression in retinoic acid-resistant human tumor cell lines. Mol. Carcinogen. 8:112-122, 1993.

Van Stekelenburg-Hamers, A.E.P., Van Inzen, W.G., Van Achterberg, T.A.E., Kruip, T.A.M., De Laat, S.W. and Weima, S.M. Nuclear transfer and electrofusion in bovine in vitro-matured/in vitro-fertilized embryos:effect of media and electrical fusion parameters. Mol.Reprod.Dev. 36:307-312, 1993.

Van Zoelen, E.J.J., Delaey, B., Van Der Burg, B. and Huylebroeck, D. Detection of polypeptide growth factors: application of specific bio-assays and PCR technology. In: Growth Factors: a Practical Approach, edited by McKay, J. and Leigh, J. Oxford: Univ.Press., 1993, p. 13-34. The Practical Approach Series.

Verhaagen, J., Koster, J.G., Schrama, L.H., Eggen, B.J.L., Van Der Neut, R., Gispen, W.H. and Destrée, O.H.J. The rat B-50(GAP-43) promoter directs neural-preferred expression of a reporter gene in Xenopus laevis embryos. Neurosci.Res.Comm. 13:83-90, 1993.

Verwey, A. Three-dimensional analysis of light microscope images. A method for studying cell fate in the mouse embryo. Thesis, Tech. Univ. Delft, pp. 1-140, 1993. 

Vogels, R., Charité, J., De Graaff, W.G.A.J. and Deschamps, J.T. Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice. Development 118:71-82, 1993.

Zwartkruis, G.J.T., Kruyt, F.A.E., Van Der Saag, P.T. and Meijlink, F. Induction of Hox-2 genes in P19 embryocarcinoma cells is dependent on retinoic acid receptor a. Exp.Cell Res. 205:422-425, 1993.

1992
Proc. Symposia & Meeting COSPAR 28th Plenary Meeting; Life Sciences and Space Research XXIV (1); Gravitational Biology; The Hague, June-July 1990, Oxford:Pergamon Press, 1992. pp. 1-402. Adv. Space Research, 12, no.1.

Akhurst, R.J., Fitzpatrick, D.R., Fowlis, D.J., Gatherer, D., Millan, F.A. and Slager, H.G. The role of TGF-bs in mammalian development and neoplasia. Mol.Reprod.Dev. 32:127-135, 1992.

De Jong, R., De Laaf, R.T.M., Vennema, H. and Meijlink, F. DNA-binding activity of the murine homeodomain protein Hox-2.3 produced by a hybrid phage T7/vaccinia virus system. Gene 116:195-203, 1992.

De Laat, S.W., De Groot, R.P., Den Hertog, J., Rijken, P.J., Verkleij, A.J., Kruijer, W. and Boonstra, J. Epidermal growth factor induced signal transduction in A431 cells is influenced by altered gravity conditions. The Physiologist 35,Suppl.:S19-S21, 1992.

De Loos, F.A.M., Van Maurik, W.A.M., Van Beneden, T. and Kruip, T.A.M. Structural aspects of bovine oocyte maturation in vitro. Mol.Reprod.Dev. 31:208-214, 1992.

Dekker, E.-J., Pannese, M., Houtzager, E., Timmermans, J.P.M., Boncinelli, E. and Durston, A.J. Xenopus Hox-2 genes are expressed sequentially after the onset of gastrulation and are differentially inducible by retinoic acid. Development Suppl.:195-202, 1992.

Den Hertog, J., De Groot, R.P., De Laat, S.W. and Kruijer, W. EGF-induced junB-expression in transfected P19 embryonal carcinoma cells expressing EGF-receptors is dependent on junD. Nucl.Acids Res. 20:125-130, 1992.

Den Hertog, J. Phosphotyrosine and neuronal differentiation of kinases and phosphatases. Thesis, Univ. Utrecht, pp. 1-107, 1992.

Den Hertog, J., Pals, C.E.G.M., Jonk, L.J.C. and Kruijer, W. Differential expression of a novel murine non-receptor protein tyrosine phosphatase during differentiation of P19 embryonal carcinoma cells. Biochem.Biophys.Res.Comm. 184:1241-1249, 1992.

Deschamps, J.T. and Meijlink, F. Mammalian homeobox genes in normal development and neoplasia. Crit.Rev.Oncogen. 3:117-173, 1992.

Destrée, O.H.J., Lam, K.T., Peterson-Maduro, L.J., Eizema, K., Diller, L., Gryka, M.A., Frebourg, T., Shibuya, E. and Friend, S.H. Structure and expression of the Xenopus retinoblastoma gene. Dev.Biol. 153:141-149, 1992.

Good, M.J., Hage, W.J., Mummery, C.L., De Laat, S.W. and Boonstra, J. Localization and quantification of epidermal growth factor receptors on single cells by confocal laser scanning microscopy. J.Histochem.Cytochem. 40:1353-1361, 1992.

Jonk, L.J.C., De Jonge, M.E.J., Kruyt, F.A.E., Mummery, C.L., Van Der Saag, P.T. and Kruijer, W. Aggregation and cell cycle dependent retinoic acid receptor mRNA expression in P19 embryonal carcinoma cells. Mech.of Dev. 36:165-172, 1992.

Kastrop, P.M.M., Bevers, M.M., Destrée, O.H.J., Dieleman, S.J. and Kruip, T.A.M. The influence of the preovulatory LH-peak on protein synthesis and phosphorylation in bovine oocytes from follicles of different size and quality. Anim.Reprod.Sc. 29:133-143, 1992.

Katahira, M., Knegtel, R.M.A., Boelens, R., Eib, D., Schilthuis, J.G., Van Der Saag, P.T. and Kaptein, R. Homo- and heteronuclear NMR studies of the human retinoic acid receptor b DNA-binding domain: sequential assignments and identification of secondary structure elements. Biochemistry 31:6474-6480, 1992.

Kruyt, F.A.E., Van Der Veer, L.J., Mader, S., Van Den Brink, C.E., Feijen, A., Jonk, L.J.C., Kruijer, W. and Van Der Saag, P.T. Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RARa. Differentiation 49:27-37, 1992.

Kruyt, F.A.E., Folkers, G.E., Van Den Brink, C.E. and Van Der Saag, P.T. A cyclic AMP response element is involved in retinoic acid-dependent RARb2 promoter activation. Nucl.Acids Res. 20:6393-6399, 1992.

Kruyt, F.A.E. Regulation of the retinoic acid receptor b promoter. Thesis, Univ. Utrecht, pp. 1-109, 1992.

Lawson, K.A. and Pedersen, R.A. Early mesoderm formation in the mouse embryo. In: Formation and Differentiation of Early Embryonic Mesoderm, edited by Bellairs, R., Sanders, E.J. and Lash, J.W. N.Y.: Plenum Press, 1992, p. 33-46. Proc. NATO Adv. Res. Workshop on Formation and Differentiation of Early Embryonic Mesoderm, Banff, Alberta, Canada, October 1991; NATO ASI Series, Series A: Life Sciences.

Lawson, K.A. and Pedersen, R.A. Clonal analysis of cell fate during gastrulation and early neurulation in the mouse. In: Postimplantation development in the mouse, edited by J.Marsh,  London: Chichester, Wiley, 1992, p. 3-26. CIBA Found. Symp., 165.

Nieuwkoop, P.D. The formation of the mesoderm in urodelian amphibians. VI. The self-organizing capacity of the induced meso-endoderm. Roux's Arch.Dev.Biol. 201:18-29, 1992.

Peppelenbosch, M.P., Tertoolen, L.G.J., Den Hertog, J. and De Laat, S.W. Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production. Cell 69:295-303, 1992.

Pijnappel, W.W.M., Hendriks, H.F.J. and Durston, A.J. Retinoids in embryonic development. Voeding 53:179-182, 1992. Proc. 2ndSymp. on Vit. A Research in the Netherlands, Mijdrecht, April 1992.

Rijken, P.J. Epidermal growth factor-induced signal transduction in microgravity. Thesis, Univ. Utrecht, pp. 1-108, 1992.

Rijken, P.J., De Groot, R.P., Kruijer, W., De Laat, S.W., Verkleij, A.J. and Boonstra, J. Identification of specific gravity sensitive signal transduction pathways in human A431 carcinoma cells. Adv.Space Res. 12:145-152, 1992.

Rijken, P.J., De Groot, R.P., Kruijer, W., Verkleij, A.J., Boonstra, J. and De Laat, S.W. Altered gravity conditions affect early EGF-induced signal transduction in human epidermal A431 cells. ASGSB Bull. 5:77-82, 1992.

San, E.J.T. Expression of B-50, a prerequisite for neuronal differentiation: sense or nonsense? Thesis, Univ. Utrecht, pp. 1-136, 1992.

Shen, S., Van Den Brink, C.E., Kruijer, W. and Van Der Saag, P.T. Embryonic stem cells stably transfected with mRARb2-lacZ exhibit specific expression in chimeric embryos. Int.J.Dev.Biol. 36:465-476, 1992.

Slager, H.G., Good, M.J., Schaart, G., Groenewoud, J.S. and Mummery, C.L. Organization of non-muscle myosin during early murine embryonic differentiation. Differentiation 50:47-56, 1992.

Slager, H.G. TGF-b2 in embryonic development. Thesis, Univ. Utrecht, pp. 1-130, 1992.

Smit, M.J., Bloemers, S.M., Leurs, R., Tertoolen, L.G.J., Bast, A., De Laat, S.W. and Timmerman, H. Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways. Brit.J.Pharmacol. 107:448-455, 1992.

Spaargaren, M., Wissink, S., Defize, L.H.K., De Laat, S.W. and Boonstra, J. Characterization and identification of an epidermal growth factor-activated phospholipase A2. Biochem.J. 287:37-43, 1992.

Spaargaren, M. Signal transduction by the epidermal growth factor receptor; activation of the receptor tyrosine kinase and phospholipase A2. Thesis, Univ. Utrecht, pp. 1-132, 1992.

Ubbels, G.A. Developmental biology on unmanned space craft. Adv.Space Res. 12:117-122, 1992.

Ubbels, G.A., Berendsen, W., Kerkvliet, S.C.J. and Narraway, J.M. Fertilization and development of eggs of the South African clawed toad, Xenopus laevis, on sounding rockets in space. Adv.Space Res. 12:181-194, 1992.

Ubbels, G.A. "Eggs" - The role of gravity in the establishment of the dorso-ventral axis in the amphibian embryo (7-IML-1). In: First International Microgravity Laboratory Experiment Descriptions; NASA Technical Memorandum, no. 4353, edited by Miller, T.Y. Washington: NASA, 1992, p. 49-53.

Van Den Eijnden-Van Raaij, A.J.M., Feijen, A., Lawson, K.A. and Mummery, C.L. Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development. Dev.Biol. 154:356-365, 1992.

Van Der Burg, B., Kalkhoven, E., Isbrücker, L. and De Laat, S.W. Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J.Ster.Biochem.Mol.Biol. 42:457-465, 1992.

Van Der Burg, B., De Groot, R.P., Isbrücker, L., Kruijer, W. and De Laat, S.W. Direct stimulation by estrogen of growth factor signal transduction pathways in human breast cancer cells. J.Ster.Biochem.Mol.Biol. 43:111-115, 1992. Proc. 4th Intern. Congr. On Hormones and Cancer, Amsterdam.

Van Der Leede, B.-J.M., Folkers, G.E., Kruyt, F.A.E. and Van Der Saag, P.T. Genomic organization of the human retinoic acid receptor b2. Biochem.Biophys.Res.Comm. 188:695-702, 1992.

Van Hemert, F.J., Jonk, L.J.C. and Destrée, O.H.J. Histone H1º mRNA and protein accumulate early during retinoic acid induced differentiation of synchronized embryonal carcinoma cells. Mol.Biol.Rep. 16:33-38, 1992.

Van Inzen, W.G., Wurth, Y.A., Verstrate-Voolstra, C., Kruip, T.A.M. and Weima, S.M. Culture of bovine embryos to the blastocyst stage in the presence of embryotrophic factors secreted by Buffalo Rat Liver (BRL) cells. In: Proc.12th Internat.Congress on Animal Reproduction, The Hague, August 1992: 1992, p. 1360-1362.

Van Pelt, A.M.M., Van Den Brink, C.E., De Rooij, D.G. and Van Der Saag, P.T. Changes in retinoic acid receptor messenger ribonucleic acid levels in the vitamin A-deficient rat testis after administration of retinoids. Endocrinology 131:344-350, 1992.

Van Stekelenburg-Hamers, A.E.P., Van Inzen, W.G., Van Achterberg, T.A.E., Kruip, T.A.M. and Weima, S.M. Nucleus transfer in bovine IVM/IVF embryos and IVM oocytes: establishment of electrofusion and activation conditions. In: Proc. 12th Intern. Congress on Animal Reproduction, p.760-762. The Hague, August, 1992.

Van Zoelen, E.J.J., Van Rotterdam, W., Ward-van Oostwaard, T.M.J. and Feijen, A. Phenotypic transformation of normal rat kidney cells by transforming growth factor b is not paralleled by enhanced production of a platelet-derived growth factor. Europ.J.Biochem. 209:89-94, 1992.

Verbeeck, M.A.E., Mummery, C.L., Feijen, A. and Burbach, J.P.H. Survey of neuropeptide gene expression in tumor cell lines. Pathobiology 60:127-135, 1992.

Vogels, R. The murine Hox-2.3 gene: expression and regulation in embryos. Thesis, Univ. Utrecht, pp. 1-126, 1992.

Weima, S.M., Van Achterberg, T.A.E., Rebel, H.G., Kruip, T.A.M. and Mummery, C.L. Isolation and characterization of permanent cell lines derived from bovine blastocysts. In: Proc. 12th Intern. Congress on Animal Reproduction,p.766-768. The Hague, August 1992.

Young, R.S., Cogoli, A., Planel, H., Ubbels, G.A., Sievers, A., Oser, H., Horneck, G. and Wagner, H. (Eds) Proc. Symposia and Meeting COSPAR 28th Plenary Meeting; Life Sciences and Space Research XXIV (1); Gravitational Biology; The Hague, June/July 1990. Oxford: Pergamon Press, 1992, 402 p.; Adv. Space Res. 12, no.1.

Zwartkruis, G.J.T., Hoeijmakers, G.H.T., Deschamps, J.T. and Meijlink, F. The murine Hox-2.4 promoter contains a functional octamer motif. Nucl.Acids Res. 20:1599-1606, 1992.

Zwartkruis, G.J.T. Transcriptional regulation of Hox-C genes. Thesis, Univ. Utrecht, pp. 1-124, 1992.

1991
Boonstra, J., De Groot, R.P., Rijken, P.J., Kruijer, W., Verkleij, A.J. and De Laat, S.W. Regulation of cell growth and differentiation by microgravity; signal transduction by growth factor receptors. Low G. 2:5-7, 1991.

De Groot, R.P. Transcription factor Jun/AP1: Key regulator in signal transduction and differentiation. Thesis, Univ. Utrecht, pp. 1-154, 1991.

De Groot, R.P., Pals, C.E.G.M. and Kruijer, W. Transcriptional control of c-jun by retinoic acid. Nucl.Acids Res. 19:1585-1591, 1991.

De Groot, R.P., Foulkes, N., Mulder, M.M., Kruijer, W. and Sassone-Corsi, P. Positive regulation of Jun/AP-1 by E1A. Mol. Cell. Biol. 11:192-201, 1991.

De Groot, R.P., Meijer, I., Van Den Brink, C.E., Mummery, C.L. and Kruijer, W. Differential regulation of JunB and JunD by adenovirus type 5 and 12 E1A proteins. Oncogene 6:2357-2361, 1991.

De Groot, R.P., Auwerx, J.A., Karperien, M., Staels, B. and Kruijer, W. Activation of junB by PKC and PKA signal transduction through a novel cis-acting element. Nucl.Acids Res. 19:775-781, 1991.

De Groot, R.P., Rijken, P.J., Den Hertog, J., Boonstra, J., Verkleij, A.J., De Laat, S.W. and Kruijer, W. Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes. Exp.Cell Res. 197:87-90, 1991.

De Groot, R.P. and Kruijer, W. Up-regulation of Jun/AP-1 during differentiation of N1E-115 neuroblastoma cells. Cell Growth Diff. 2:631-636, 1991.

De Groot, R.P., Karperien, M., Pals, C.E.G.M. and Kruijer, W. Characterization of the mouse junD promoter - high basal level activity due to an octamer motif. EMBO J. 10:2523-2532, 1991 

De Groot, R.P., Rijken, P.J., Boonstra, J., Verkleij, A.J., De Laat, S.W. and Kruijer, W. Epidermal growth factor-induced expression of c-fos is influenced by altered gravity conditions. Aviat. Space & Env. Med. 62:37-40, 1991.

De Loos, F.A.M., Kastrop, P.M.M., Van Maurik, W.A.M., Van Beneden, T. and Kruip, T.A.M. Heterologous cell contacts and metabolic coupling in bovine cumulus oocyte complexes. Mol.Reprod.Dev. 28:255-259, 1991.

De Loos, F.A.M., Bevers, M.M., Dieleman, S.J. and Kruip, T.A.M. Morphology of preovulatory bovine follicles as related to oocyte maturation. Theriogenology 35:527-535, 1991.

De Loos, F.A.M., Bevers, M.M., Dieleman, S.J. and Kruip, T.A.M. Follicular and oocyte maturation in cows treated for superovulation. Theriogenology 35:537-546, 1991.

Den Hertog, J., Eman, R., Tertoolen, L.G.J., De Laat, S.W. and Kruijer, W. Characterization of a tyrosine kinase signaling pathway in undifferentiated P19 embryonal carcinoma cells. Exp.Cell Res. 196:226-232, 1991.

Den Hertog, J., De Laat, S.W., Schlessinger, J. and Kruijer, W. Neuronal differentiation in response to epidermal growth factor of transfected murine P19 embryonal carcinoma cells expressing human epidermal growth factor receptors. Cell Growth Diff. 2:155-164, 1991.

Durston, A.J. and Otte, A.P. A hierarchy of signals mediates neural induction in Xenopus laevis. In: Cell-Cell Interactions in Early Development, edited by Gerhart, J. N.Y.: Wiley-Liss, 1991, p. 109-127. Proc. 49th Ann. Symp. Soc. Dev. Biol., Washington, June 1990.

Geurts van Kessel, A., De Leeuw, H., Dekker, E.-J., Rijks, L., Spurr, N., Ledbetter, D., Kootwijk, E. and Vaessen, M.J. Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15. Hum.Genet. 87:201-204, 1991.

Kastrop, P.M.M., Hulshof, S.C.J., Bevers, M.M., Destrée, O.H.J. and Kruip, T.A.M. The effects of alpha-amanitin and cyclo-heximide on nuclear progression, protein synthesis, and phosphorylation during bovine oocyte maturation in vitro. Mol.Reprod.Dev. 28:249-254, 1991.

Kastrop, P.M.M., Bevers, M.M., Destrée, O.H.J. and Kruip, T.A.M. Protein synthesis and phosphorylation patterns of bovine oocytes maturing in vivo. Mol.Reprod.Dev. 29:271-275, 1991 

Kramer, IJ.M., Koornneef, I., De Vries, C., De Groot, R.P., De Laat, S.W., Van Den Eijnden-Van Raaij, A.J.M. and Kruijer, W. Phosphorylation of nuclear protein is an early event in TGFb1 action. Biochem.Biophys.Res.Comm. 175:816-822, 1991.

Kramer, IJ.M., Koornneef, I., De Laat, S.W. and Van Den Eijnden-Van Raaij, A.J.M. TGFb1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CC164 cells. EMBO J. 10:1083-1089, 1991.

Kruyt, F.A.E., Van Den Brink, C.E., Defize, L.H.K., Donath, M.J., Kastner, P., Kruijer, W., Chambon, P. and Van Der Saag, P.T. Transcriptional regulation of retinoic acid receptor b in retinoic acid-sensitive and -resistant P19 embryocarcinoma cells. Mech.of Dev. 33:171-178, 1991.

Lawson, K.A., Meneses, J.J. and Pedersen, R.A. Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113:891-911, 1991.

Mummery, C.L., Van Achterberg, T.A.E., Van Den Eijnden-Van Raaij, A.J.M., Van Haaster, L., Willemse, A., De Laat, S.W. and Piersma, A.H. Visceral-endoderm-like cell lines induce differentiation of murine P19 embryonal carcinoma cells. Differentiation 46:51-60, 1991.

Mummery, C.L. and Weima, S.M. Growth factors and receptors during differentiation: A comparison of human and murine embryonal carcinoma cell lines. In: Pathobiology of Human Germ Cell Neoplasia, edited by Oosterhuis, J.W., Walt, H. and Damjanov, I. Berlin: Springer Verlag, 1991, p. 165-182. Recent Cancer Research, 123.

Nieuwkoop, P.D. The successive steps in the pattern formation of the amphibian central nervous system. Dev. Growth  Diff. 33:149-154, 1991.

Nieuwkoop, P.D. I. The different origin of the primordial germ cells (PGCs) in various groups of vertebrates. Proc. Kon. Ned. Akad. Wet. 94:103-110, 1991.

Nieuwkoop, P.D. IIB. Pattern formation in the developing central nervous system (CNS) of the amphibians and birds. Proc. Kon. Ned. Akad. Wet. 94:121-127, 1991.

Nieuwkoop, P.D. II. A pattern formation in the developing central nervous system (CNS) of the amphibians and birds. Proc. Kon. Ned. Akad. Wet. 94:111-120, 1991.

Nieuwkoop, P.D. III. The regional induction of the meso-endoderm in amphibians and birds. Proc. Kon. Ned. Akad. Wet. 94:129-136, 1991.

Oosterwegel, M., Van De Wetering, M., Dooijes, D., Klomp, L., Winoto, A., Georgopoulos, K., Meijlink, F. and Clevers, H. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-e and T cell receptor a enhancers. J.Exp. Med. 173:1133-1142, 1991.

Opstelten, D.J.E., Vogels, R., Robert, B., Kalkhoven, E., Zwartkruis, G.J.T., De Laaf, R.T.M., Destrée, O.H.J., Deschamps, J.T., Lawson, K.A. and Meijlink, F. The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech.of Dev. 34:29-42, 1991.

Otte, A.P., Kramer, IJ.M. and Durston, A.J. Protein kinase C and regulation of the local competence of Xenopus ectoderm. Science 251:570-573, 1991.

Peppelenbosch, M.P., Tertoolen, L.G.J. and De Laat, S.W. Epidermal growth factor-activated calcium and potassium channels. J. Biol.Chem. 266:19938-19944, 1991.

Rijken, P.J., Hage, W.J., Van Bergen en Henegouwen, P.M.P., Verkleij, A.J. and Boonstra, J. Epidermal growth factor induces rapid reorganization of the actin microfilament system in human A431 cells. J. Cell Sci. 100:491-499, 1991.

Rijken, P.J., De Groot, R.P., Briegleb, W., Kruijer, W., Verkleij, A.J., Boonstra, J. and De Laat, S.W. Epidermal growth factor-induced cell rounding is sensitive to stimulated microgravity. Aviat. Space & Environm. Med. 62:32-36, 1991.

Schoorlemmer, J.A. and Kruijer, W. Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells. Mech.of Dev. 36:75-86, 1991.

Shen, S., Kruyt, F.A.E., Den Hertog, J., Van Der Saag, P.T. and Kruijer, W. Mouse and human retinoic acid receptor b2 promoters: Sequence comparison and localization of retinoic acid responsiveness. DNA Sequence 2:111-119, 1991.

Slager, H.G., Lawson, K.A., Van Den Eijnden-Van Raaij, A.J.M., De Laat, S.W. and Mummery, C.L. Differential localization of TGF-b2 in mouse preimplantation and early postimplantation development. Dev.Biol. 145:205-218, 1991.

Slootweg, M.C., De Groot, R.P., Herrmann-Erlee, M.P.M., Koornneef, I., Kruijer, W. and Kramer, IJ.M. Growth hormone induces expression of c-jun and junB oncogens and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression. J. Mol.Endocrinol. 6:179-188, 1991.

Spaargaren, M., Defize, L.H.K., Boonstra, J. and De Laat, S.W. Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase. J. Biol.Chem. 266:1733-1739, 1991.

Spaargaren, M., Defize, L.H.K., Boonstra, J. and De Laat, S.W. Dimerization activates the epidermal growth factor receptor tyrosine kinase. In: Biological Signal Transduction, edited by Ross, E.M. and Wirtz, K.W.A. Berlin: Springer, 1991, p. 45-58. Proc. NATO Adv. Res. Inst. on Biological Signal Transduction, Spetsai, Greece, August 1990; NATO ASI Series, Series H: Cell Biology, 52.

Speksnijder, J.E., Teerds, K.J., Hage, W.J. and Dohmen, M.R. Polar effects of concanavalin A on the cortical cytoskeleton of a molluscan egg (Nassarius reticulatus, Gastropoda). Roux's Arch.Dev.Biol. 200:8-20, 1991.

Ubbels, G.A. The role of gravity in the establishment of the dorso-ventral axis in the amphibian embryo. Micrograv. News ESA 4:16-17, 1991.

Van Den Eijnden-Van Raaij, A.J.M., Koornneef, I., Zwartkruis, G.J.T., Nieuwland, R. and Van Zoelen, E.J.J. Cation-exchange high-performance liquid chromatography: group separation of acidic and basic proteins using volatile solvents. In: Hig-performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation, edited by C.T.Mant, and R.S.Hodges, BocaRaton etc., CRC Press, 1991, p. 239-244.

Van Den Eijnden-Van Raaij, A.J.M., Van Achterberg, T.A.E., Van Der Kruijssen, C.M.M., Piersma, A.H., Huylebroeck, D., De Laat, S.W. and Mummery, C.L. Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A. Mech.of Dev. 33:157-166, 1991.

Van Der Burg, B. and De Laat, S.W. Molecular action of steroids and growth factors in human breast tumor cells. In: Cell to Cell Signals in Plants and Animals, edited by Neuhoff, V. and Friend, J. Berlin : Springer, 1991, p. 256-287. NATO ASI Series, Series H: Cell Biology, 51.

Van Der Burg, B., De Groot, R.P., Isbrücker, L., Kruijer, W. and De Laat, S.W. Oestrogen directly stimulates growth factor signal transduction pathways in human breast cancer cells. J.Steroid Biochem.Mol.Biol. 40:215-221, 1991.

Van Der Burg, B. Sex steroids and growth factors in mammary cancer. In: Proc. Symp. "Animals-Hormones-Aging and Cancer". Utrecht: 1991, p. 38-41. Sept. 1991. Acta Endocrinol., 125, suppl. 1.

Van Der Burg, B. and De Laat, S.W. Regulatie van bortsttumorgroei: een modelsysteem voor tumorontwikkeling. Kanker 15:58-61, 1991.

Van Zoelen, E.J.J. and Tertoolen, L.G.J. Transforming growth factor-b enhances the extent of intercellular communication between normal rat kidney cells. J. Biol.Chem. 266:12075-12081, 1991.

Westerhoff, H.V. and Koster, J.G. Organization of histone genes and regulation and control of their expression in early development. In: Molecular Theories of Cell Life and Death, edited by Sungchul, Ji. New Brunswick: Univ. Press, 1991, p. 442-472.

Zwartkruis, G.J.T., Hoeijmakers, G.H.T., Deschamps, J.T. and Meijlink, F. Characterization of the murine Hox-2.3 promoter: involvement of the transcription factor USF (MLTF). Mech.of Dev. 33:179-190, 1991.