PhD Student

Research group

Prof. dr. Edwin Cuppen

To work on

Understanding the effects of genetic variation on phenotypic diversity

Appointment

full-time (38 hours/week)

Starting date

before February 15th

Duration

4 years

Location

Utrecht

Vacature #

HI-2010-02

Description of the project:
The major goal of this project is to investigate how different types of genetic variation (single nucleotide polymorphisms, copy number variation, structural variation) affect molecular phenotypes. Unique genetic model systems in the rat will be employed to systematically collect genomic, transcriptomic, but also epi-genetic data, mostly using state-of-the-art next-generation sequencing techniques. In collaboration with bioinformaticians, data will be integrated in a systems-genetics approach and mechanistic models will be developed and experimentally tested. Eventually, such insights will help to understand and interpret personal genomes, which are expected to become available in the very near future (also through the joint appointment of the PI at the Medical Genetics department of the University Medical Center Utrecht, which has resulted in a close collaboration between model organism and human genetic research).

Requirements:
We are looking for a highly motivated scientist. The candidate should have an MSc degree. Knowledge of standard laboratory techniques such as PCR, cloning, and DNA sequencing is required. Fluency in English is necessary.

Salary:
According to “CAO-Nederlandse Universiteiten” (CAO-NU):
€ 2.042,- in the first year, increasing to € 2.612,- in the fourth year, excluding 8% holiday allowance and an 8, 3 % year-end allowance.